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Influence of Macrocyclic Chelators on the Targeting Properties of 68Ga-Labeled Synthetic Affibody Molecules : Comparison with 111In-Labeled Counterparts
Free accessBASE | 2013|68Ga (T1/2 = 67.6 min). Earlier studies have demonstrated that the chemical nature of chelators has a substantial influence on the ...Keywords: Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology -
Targeting Tumor Cells Overexpressing the Human Epidermal Growth Factor Receptor 3 with Potent Drug Conjugates Based on Affibody Molecules
Free accessBASE | 2022|carcinoma cell line, BxPC-3. The drug conjugate showed a potent cytotoxic effect on BxPC-3 cells with an IC50 value of 7 nM. Evaluation of a ...Keywords: Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology -
Increase in negative charge of 68Ga/chelator complex reduces unspecific hepatic uptake but does not improve imaging properties of HER3-targeting affibody molecules
Free accessBASE | 2019|Upregulation of the human epidermal growth factor receptor type 3 (HER3) is a common mechanism to bypass HER-targeted cancer therapy ...Keywords: Nuclear Medicine and Medical Imaging, Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology -
Preclinical Evaluation of [Ga-68]Ga-DFO-ZEGFR:2377 : A Promising Affibody-Based Probe for Noninvasive PET Imaging of EGFR Expression in Tumors
Free accessBASE | 2018|predict response or resistance to certain treatments. Affibody molecules, which are nonimmunoglobulin scaffold proteins, have a high potential as ...Keywords: Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology -
177Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry
Free accessBASE | 2023|patients. Earlier, we optimized a urea-based probe for radionuclide visualization of PSMA-expression in vivo using computer modeling. With the ...Keywords: Nuclear Medicine and Medical Imaging, Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology -
Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands
Free accessBASE | 2022|radioligands with modified linker structures, focusing on the relationship between molecular structure and targeting properties. The linker design was ...Keywords: Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology
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