1,3-dichloro-2-propanol: 13-week Gavage Toxicity Study in Sprague-dawley Rats (Final Report) with Cover Letter (English)

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1,3-Dichloro-2-propanol (DCP) was evaluated for subchronic toxicity in Sprague-Dawley rats (10/sex/dose group) administered dose levels of 0, 0.1, 1, 10, or 100 mg DCP/kg bw/day by gavage in distilled water 5 days/week for 13 weeks. No adverse clinical signs were observed during the study in any dose group. Final body weight gain was 8% lower in high-dose males than in control rats. Sporadic decreases in food consumption were observed in high-dose males and females. Exposure to 100 mg/kg DCP induced a statistically significant decrease in hemoglobin and hematocrit in both sexes. High-dose females showed a significant increasein urinary proteins, but this effect was not observed in males. Numerous clinical chemistry effects detected were a reflection of liver damage in high-dose males and females and of kidney damage in high-dose females. Absolute and relative liver and kidney weights were significantly increased in high-dose groups. Gross pathology effects attributed to DCP-treatment were limited to gastric irritation in the 10 and 100 mg/kg groups. Histopathological alterations due to treatment with DCP were confined to the stomach, liver, and kidney of rats given 10 and 100 mg/kg, and to the nasal tissues of rats in the high-dose groups. The 1 mg/kg dose was the no-adverse-effect level.