4-Phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives, a novel class of selective δ-opioid agonists (Englisch)

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Graphical contents list
| 2005
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Targeting the DNA minor groove with fused ring dicationic compounds: Comparison of in silico screening and a high-resolution crystal structure
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N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: Mode of binding in a complex with MMP-8
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Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2)
Ulmschneider, Sarah / Negri, Matthias / Voets, Marieke / Hartmann, Rolf W. | 2005
31
Design, synthesis and in vitro antimalarial activity of an acylhydrazone library
Melnyk, Patricia / Leroux, Virginie / Sergheraert, Christian / Grellier, Philippe | 2005
36
Peptide inhibitors of dengue virus NS3 protease. Part 1: Warhead
Yin, Zheng / Patel, Sejal J. / Wang, Wei-Ling / Wang, Gang / Chan, Wai-Ling / Rao, K.R. Ranga / Alam, Jenefer / Jeyaraj, Duraiswamy A. / Ngew, Xinyi / Patel, Viral et al. | 2005
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Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors
Yin, Zheng / Patel, Sejal J. / Wang, Wei-Ling / Chan, Wai-Ling / Ranga Rao, K.R. / Wang, Gang / Ngew, Xinyi / Patel, Viral / Beer, David / Knox, John E. et al. | 2005
44
Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: Potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility
Ban, Hitoshi / Muraoka, Masami / Ioriya, Katsuhisa / Ohashi, Naohito | 2005
49
Synthesis of the PPARβ/δ-selective agonist GW501516 and C4-thiazole-substituted analogs
Pereira, Raquel / Gaudon, Claudine / Iglesias, Beatriz / Germain, Pierre / Gronemeyer, Hinrich / de Lera, Angel R. | 2005
49
Synthesis of the PPAR#946-#948-selective agonist GW501516 and C4-thiazole-substituted analogs
Pereira, Raquel / Gaudon, Claudine / Iglesias, Beatriz / Germain, Pierre / Gronemeyer, Hinrich / de Lera, Angel R. | 2006
55
Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative
Kinoshita, Takayoshi / Warizaya, Masaichi / Ohori, Makoto / Sato, Kentaro / Neya, Masahiro / Fujii, Takashi | 2005
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3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors
Weide, Timo / Arve, Lars / Prinz, Heino / Waldmann, Herbert / Kessler, Horst | 2005
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p38 MAP kinase inhibitors: Metabolically stabilized piperidine-substituted quinolinones and naphthyridinones
Bao, Jianming / Hunt, Julianne A. / Miao, Shouwu / Rupprecht, Kathleen M. / Stelmach, John E. / Liu, Luping / Ruzek, Rowena D. / Sinclair, Peter J. / Pivnichny, James V. / Hop, Cornelis E.C.A. et al. | 2005
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Hexylitaconic acid: A new inhibitor of p53#8211HDM2 interaction isolated from a marine-derived fungus, Arthrinium sp.
Tsukamoto, Sachiko / Yoshida, Takushi / Hosono, Hidetaka / Ohta, Tomihisa / Yokosawa, Hideyoshi | 2006
69
Hexylitaconic acid: A new inhibitor of p53–HDM2 interaction isolated from a marine-derived fungus, Arthrinium sp.
Tsukamoto, Sachiko / Yoshida, Takushi / Hosono, Hidetaka / Ohta, Tomihisa / Yokosawa, Hideyoshi | 2005
72
Pyrazole CCK1 receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free–Wilson additivity
McClure, Kelly / Hack, Michael / Huang, Liming / Sehon, Clark / Morton, Magda / Li, Lina / Barrett, Terrance D. / Shankley, Nigel / Breitenbucher, J. Guy | 2005
72
Pyrazole CCK1 receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free#8211Wilson additivity
Mcclure, Kelly / Hack, Michael / Huang, Liming / Sehon, Clark / Morton, Magda / Li, Lina / Barrett, Terrance D. / Shankley, Nigel / Breitenbucher, J.Guy | 2006
77
Pyrazole CCK1 receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free–Wilson additivity
Sehon, Clark / McClure, Kelly / Hack, Michael / Morton, Magda / Gomez, Laurent / Li, Lina / Barrett, Terrance D. / Shankley, Nigel / Breitenbucher, J. Guy | 2005
77
Pyrazole CCK1 receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free#8211Wilson additivity
Sehon, Clark / Mcclure, Kelly / Hack, Michael / Morton, Magda / Gomez, Laurent / Li, Lina / Barrett, Terrance D. / Shankley, Nigel / Breitenbucher, J.Guy | 2006
81
Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells
Du, AiYing / Zhao, BaoXiang / Yin, DeLing / Zhang, ShangLi / Miao, JunYing | 2005
84
NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies
Ettmayer, Peter / Baumruker, Thomas / Guerini, Danilo / Mechtcheriakova, Diana / Nussbaumer, Peter / Streiff, Markus B. / Billich, Andreas | 2005
88
The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
Heikkilä, Timo / Thirumalairajan, Srinath / Davies, Matthew / Parsons, Mark R. / McConkey, A. Glenn / Fishwick, Colin W.G. / Johnson, A. Peter | 2005
93
Analogues of N-terminal truncated synthetic peptide fragments derived from RANTES inhibit HIV-1 infectivity
Ramnarine, Emabelle J. / DeVico, Anthony L. / Vigil-Cruz, Sandra C. | 2005
96
Scaffold oriented synthesis. Part 1: Design, preparation, and biological evaluation of thienopyrazoles as kinase inhibitors
Akritopoulou-Zanze, Irini / Darczak, Daria / Sarris, Kathy / Phelan, Kathleen M. / Huth, Jeffrey R. / Song, Danying / Johnson, Eric F. / Jia, Yong / Djuric, Stevan W. | 2005
100
Tetrahydrobenzothiophene inhibitors of hepatitis C virus NS5B polymerase
LaPorte, M.G. / Lessen, T.A. / Leister, L. / Cebzanov, D. / Amparo, E. / Faust, C. / Ortlip, D. / Bailey, T.R. / Nitz, T.J. / Chunduru, S.K. et al. | 2005
104
The design, synthesis, and evaluation of two universal doxorubicin-linkers: Preparation of conjugates that retain topoisomerase II activity
Sun, Chengzao / Aspland, Simon E. / Ballatore, Carlo / Castillo, Rosario / Smith, Amos B. III / Castellino, Angelo J. | 2005
108
Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK
Waelchli, Rudolf / Bollbuck, Birgit / Bruns, Christian / Buhl, Thomas / Eder, Jörg / Feifel, Roland / Hersperger, Rene / Janser, Philipp / Revesz, Laszlo / Zerwes, Hans-Günter et al. | 2005
113
Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents
Coppola, Gary M. / Damon, Robert E. / Eskesen, J. Bruce / France, Dennis S. / Paterniti, James R. Jr. | 2005
118
Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection
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123
Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors
Qiao, Lei / Baumann, Christian A. / Crysler, Carl S. / Ninan, Nisha S. / Abad, Marta C. / Spurlino, John C. / DesJarlais, Renee L. / Kervinen, Jukka / Neeper, Mike P. / Bayoumy, Shariff S. et al. | 2005
129
Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases
Han, Sun-Young / Park, Seok-Soon / Lee, Woo Ghil / Min, Yong Ki / Kim, Bum Tae | 2005
134
Design and synthesis of downsized metastin (45#821154) analogs with maintenance of high GPR54 agonistic activity
Niida, Ayumu / Wang, Zixuan / Tomita, Kenji / Oishi, Shinya / Tamamura, Hirokazu / Otaka, Akira / Navenot, Jean-Marc / Broach, James R. / Peiper, Stephen C. | 2006
134
Design and synthesis of downsized metastin (45–54) analogs with maintenance of high GPR54 agonistic activity
Niida, Ayumu / Wang, Zixuan / Tomita, Kenji / Oishi, Shinya / Tamamura, Hirokazu / Otaka, Akira / Navenot, Jean-Marc / Broach, James R. / Peiper, Stephen C. / Fujii, Nobutaka | 2005
138
New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies
Urbani, Paolo / Cavallo, Paolo / Cascio, Maria Grazia / Buonerba, Mariafrancesca / De Martino, Giovanni / Di Marzo, Vincenzo / Saturnino, Carmela | 2005
142
The structure–activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs
Suh, Young-Ger / Kim, Sun Nam / Shin, Dong-Yun / Hyun, Soon-Sil / Lee, Do-Sang / Min, Kyung-Hoon / Han, Sae Mi / Li, Funan / Choi, Eung-Chil / Choi, Seong-Hak | 2005
142
The structure#8211activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs
Suh, Young-Ger / Kim, Sun Nam / Shin, Dong-Yun / Hyun, Soon-Sil / Lee, Do-Sang / Min, Kyung-Hoon / Han, Sae Mi / Li, Funan / Choi, Eung-Chil | 2006
146
4-Phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives, a novel class of selective δ-opioid agonists
Trabanco, Andrés A. / Pullan, Shirley / Alonso, José M. / Alvarez, Rosa M. / Andrés, José I. / Boeckx, Inge / Fernández, Javier / Gómez, Antonio / Iturrino, Laura / Janssens, Frans E. et al. | 2005
146
4-Phenyl-4-(1H-imidazol-2-yl)-piperidine derivatives, a novel class of selective #948-opioid agonists
Trabanco, Andrés A. / Pullan, Shirley / Alonso, José M. / Alvarez, Rosa M. / Andrés, José I. / Boeckx, Inge / Fernández, Javier / Gomez, Antonio / Iturrino, Laura | 2006
150
3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective α1-adrenoceptor ligands
Pittalà, Valeria / Romeo, Giuseppe / Salerno, Loredana / Siracusa, Maria Angela / Modica, Maria / Materia, Luisa / Mereghetti, Ilario / Cagnotto, Alfredo / Mennini, Tiziana / Marucci, Gabriella et al. | 2005
150
3-Arylpiperazinylethyl-1H-pyrrolo(2,3-d)pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective #9451-adrenoceptor ligands
Pittalà, Valeria / Romeo, Giuseppe / Salerno, Loredana / Siracusa, Maria Angela / Modica, Maria / Materia, Luisa / Mereghetti, Ilario / Cagnotto, Alfredo / Mennini, Tiziana | 2006
154
Photoreactive threading agent that specifically binds to abasic sites in DNA
Martelli, Alain / Jourdan, Muriel / Constant, Jean-François / Demeunynck, Martine / Dumy, Pascal | 2005
158
Affinity identification of δ-opioid receptors using latex nanoparticles
Hasegawa, Makoto / Ohno, Hiroshi / Tanaka, Hiroshi / Hatakeyama, Mamoru / Kawaguchi, Haruma / Takahashi, Takashi / Handa, Hiroshi | 2005
158
Affinity identification of #948-opioid receptors using latex nanoparticles
Hasegawa, Makoto / Ohno, Hiroshi / Tanaka, Hiroshi / Hatakeyama, Mamoru / Kawaguchi, Haruma / Takahashi, Takashi / Handa, Hiroshi | 2006
162
A novel class of potent influenza virus inhibitors: Polysubstituted acylthiourea and its fused heterocycle derivatives
Sun, Chuanwen / Huang, Hai / Feng, Meiqing / Shi, Xunlong / Zhang, Xiaodong / Zhou, Pei | 2005
167
New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists
Zappalà, Maria / Pellicanò, Alessia / Micale, Nicola / Menniti, Frank S. / Ferreri, Guido / De Sarro, Giovambattista / Grasso, Silvana / De Micheli, Carlo | 2005
171
Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C
Lavergne, Olivier / Fernandes, Anne-Cécile / Bréhu, Laetitia / Sidhu, Alban / Brézak, Marie-Christine / Prévost, Grégoire / Ducommun, Bernard / Contour-Galcera, Marie-Odile | 2005
176
Pulvinones as bacterial cell wall biosynthesis inhibitors
Antane, Schuyler / Caufield, Craig E. / Hu, William / Keeney, David / Labthavikul, Pornpen / Morris, Koi / Naughton, Shaughnessy M. / Petersen, Peter J. / Rasmussen, Beth A. / Singh, Guy et al. | 2005
181
C8c–C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties
Banwell, Martin G. / Bezos, Anna / Burns, Christopher / Kruszelnicki, Irma / Parish, Christopher R. / Su, Stephen / Sydnes, Magne O. | 2005
181
C8c#8211C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties
Banwell, Martin G. / Bezos, Anna / Burns, Christopher / Kruszelnicki, Irma / Parish, Christopher R. / Su, Stephen / Sydnes, Magne O. | 2006
186
Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5]
Bennett, Frank / Saksena, Anil K. / Lovey, Raymond G. / Liu, Yi-Tsung / Patel, Naginbhai M. / Pinto, Patrick / Pike, Russel / Jao, Edwin / Girijavallabhan, Viyyoor M. / Ganguly, Ashit K. et al. | 2005
191
Macrocyclic peptidomimetic inhibitors of β-secretase (BACE): First X-ray structure of a macrocyclic peptidomimetic-BACE complex
Rojo, Isabel / Martín, José Alfredo / Broughton, Howard / Timm, David / Erickson, Jon / Yang, Hsiu-Chiung / McCarthy, James R. | 2005
191
Macrocyclic peptidomimetic inhibitors of #946-secretase (BACE): First X-ray structure of a macrocyclic peptidomimetic-BACE complex
Rojo, Isabel / Martin, José Alfredo / Broughton, Howard / Timm, David / Erickson, Jon / Yang, Hsiu-Chiung / Mccarthy, James R. | 2006
196
Synthesis and preliminary biological evaluation of (2S,1′R,2′S)- and (2S,1′S,2′R)-2-(2′-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues
Amori, Laura / Serpi, Michaela / Marinozzi, Maura / Costantino, Gabriele / Diaz, Monica Gavilan / Hermit, Mette Brunsgaard / Thomsen, Christian / Pellicciari, Roberto | 2005
196
Synthesis and preliminary biological evaluation of (2S,1#8242R,2#8242S)- and (2S,1#8242S,2#8242R)-2-(2#8242-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues
Amori, Laura / Serpi, Michaela / Marinozzi, Maura / Costantino, Gabriele / Diaz, Monica Gavilan / Hermit, Mette Brunsgaard / Thomsen, Christian / Pellicciari, Roberto | 2006
200
Identification and initial evaluation of 4-N-aryl-[1,4]diazepane ureas as potent CXCR3 antagonists
Cole, Andrew G. / Stroke, Ilana L. / Brescia, Marc-Raleigh / Simhadri, Srilatha / Zhang, Joan J. / Hussain, Zahid / Snider, Michael / Haskell, Christopher / Ribeiro, Sofia / Appell, Kenneth C. et al. | 2005
204
Optimization of CCR4 antagonists: Side-chain exploration
Purandare, Ashok V. / Wan, Honghe / Gao, Aiming / Somerville, John / Burke, Christine / Vaccaro, Wayne / Yang, XiaoXia / McIntyre, Kim W. / Poss, Michael A. | 2005
208
In vitro photo-release of a TRPV1 agonist
Carr, James L. / Wease, Kerrie N. / Van Ryssen, Michael P. / Paterson, Suzanne / Agate, Ben / Gallagher, Katherine A. / Brown, C. Tom A. / Scott, Roderick H. / Conway, Stuart J. | 2005
213
Modular polyketide synthases: Investigating intermodular communication using 6 deoxyerythronolide B synthase module 2
Moffet, David A. / Khosla, Chaitan / Cane, David E. | 2005
217
Synthesis and monoamine transporter affinity of new 2β-carbomethoxy-3β-[aryl or heteroaryl]phenyltropanes
Tamagnan, Gilles / Alagille, David / Fu, Xing / Kula, Nora S. / Baldessarini, Ross J. / Innis, Robert B. / Baldwin, Ronald M. | 2005
217
Synthesis and monoamine transporter affinity of new 2#946-carbomethoxy-3#946-(aryl or heteroaryl)phenyltropanes
Tamagnan, Gilles / Alagille, David / Fu, Xing / Kula, Nora S. / Baldessarini, Ross J. / Innis, Robert B. / Baldwin, Ronald M. | 2006
221
Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents
Suresh Babu, K. / Hari Babu, T. / Srinivas, P.V. / Hara Kishore, K. / Murthy, U.S.N. / Rao, J. Madhusudana | 2005
225
Design, synthesis, and biological evaluation of the N-diarylalkenyl-piperidinecarboxylic acid derivatives as GABA uptake inhibitors (I)
Zheng, Jianbin / Wen, Ren / Luo, Xiaomin / Lin, Guoqiang / Zhang, Jiange / Xu, Linfeng / Guo, Lihe / Jiang, Hualiang | 2005
228
The crystal structures of 3-TAPAP in complexes with the urokinase-type plasminogen activator and picrate
Żesławska, Ewa / Jacob, Uwe / Stürzebecher, Jörg / Oleksyn, Barbara J. | 2005
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| 2005
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| 2005

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