Echocardiography in a toxicology setting (Englisch)

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
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Inhaltsverzeichnis – Band 81

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1
Recalibration of nonclinical safety pharmacology assessment to anticipate evolving regulatory expectations
Pugsley, Michael K. / Authier, Simon / Hayes, Eric S. / Hamlin, Robert L. / Accardi, Michael V. / Curtis, Michael J. | 2016
9
Pharmacotherapy of inborn errors of metabolism illustrating challenges in orphan diseases
Das, Anibh M. | 2016
15
The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress
Colatsky, T. / Fermini, B. / Gintant, G. / Pierson, J. B. / Sager, P. / Sekino, Y. / Strauss, D. G. / Stockbridge, N. | 2016
21
Comprehensive in vitro Proarrhythmia Assay (CiPA): Pending issues for successful validation and implementation
Cavero, I. / Guillon, J. M. / Ballet, V. / Clements, M. / Gerbeau, J. F. / Holzgrefe, H. | 2016
37
Safety pharmacology investigations on the nervous system: An industry survey
Authier, Simon / Arezzo, Joseph / Delatte, Marcus S. / Kallman, Mary-Jeanne / Markgraf, Carrie / Paquette, Dominique / Pugsley, Michael K. / Ratcliffe, Sian / Redfern, William S. / Stevens, Joanne et al. | 2016
47
The emerging role of in vitro electrophysiological methods in CNS safety pharmacology
Accardi, Michael V. / Pugsley, Michael K. / Forster, Roy / Troncy, Eric / Huang, Hai / Authier, Simon | 2016
60
The effects of housing conditions on baseline cardiovascular parameters and the sensitivity to detect changes in contractility in telemetry-implanted dogs
Sadekova, N. / Boudreau, G. / Jalbert, B. / Norton, K. | 2016
75
Social housing of non-rodents during cardiovascular recordings in safety pharmacology and toxicology studies
Prior, H. / Bottomley, A. / Champéroux, P. / Cordes, J. / Delpy, E. / Dybdal, N. / Edmunds, N. / Engwall, M. / Foley, M. / Hoffmann, M. | 2016
88
ECG telemetry in conscious guinea pigs
Ruppert, S. / Vormberge, T. / Igl, B. W. / Hoffmann, M. | 2016
99
Unlock the information in your data: Software to find, classify, and report on data patterns and arrhythmias
Mehendale, A. C. / Doyle, J. M. / Kolin, C. M. / Kroehle, J. P. | 2016
107
Characterization of an investigative safety pharmacology model to assess comprehensive cardiac function and structure in chronically instrumented conscious beagle dogs
Regan, Christopher P. / Stump, Gary L. / Detwiler, Theodore J. / Chen, Li / Regan, Hillary K. / Gilberto, David B. / DeGeorge, Joseph J. / Sannajust, Frederick J. | 2016
115
Evaluation of a method utilizing PhysioFlow®, a novel signal morphology-based form of impedance cardiography, to measure cardiac output in the conscious beagle
Payseur, J. D. / Rigney, J. J. / Turner, S. L. / Wu, X. / Murphy, D. J. / Rossman, E. I. | 2016
120
Rat cardiovascular telemetry: Marginal distribution applied to positive control drugs
Accardi, M. V. / Troncy, E. / Abtout, S. / Ascah, A. / Maghezzi, S. / Authier, S. | 2016
128
Statistical power analysis of cardiovascular safety pharmacology studies in conscious rats
Bhatt, Siddhartha / Li, Dingzhou / Flynn, Declan / Wisialowski, Todd / Hemkens, Michelle / Steidl-Nichols, Jill | 2016
136
QT interval correction for drug-induced changes in body temperature during integrated cardiovascular safety assessment in regulatory toxicology studies in dogs: A case study
El Amrani, Abdel-Ilah / El Amrani-Callens, Francine / Loriot, Stéphane / Singh, Pramila / Forster, Roy | 2016
144
Cardiovascular safety assessments in the cynomolgus monkey: Unmasking potential background arrhythmias in general toxicity studies
Greiter-Wilke, Andrea / Baird, Ted / O'Donohue, Kyle / Koerner, Annette | 2016
151
Assessment of drug-induced proarrhythmia: The importance of study design in the rabbit left ventricular wedge model
Lu, H. R. / Gallacher, D. J. / Yan, G. X. | 2016
161
How to determine cardiac ion channels targeted by drugs using the isolated rabbit ventricular wedge model
Liu, G. / Liu, T. / Cohen, D. / Yan, G. X. | 2016
171
Shortening of the electromechanical window in the ketamine/xylazine-anesthetized guinea pig model to assess pro-arrhythmic risk in early drug development
Morissette, P. / Regan, C. / Fitzgerald, K. / Gerenser, P. / Travis, J. / Wang, S. / Fanelli, P. / Sannajust, F. | 2016
183
Human ex-vivo action potential model for pro-arrhythmia risk assessment
Page, Guy / Ratchada, Phachareeya / Miron, Yannick / Steiner, Guido / Ghetti, Andre / Miller, Paul E. / Reynolds, Jack A. / Wang, Ken / Greiter-Wilke, Andrea / Polonchuk, Liudmila et al. | 2016
196
Points to consider for a validation study of iPS cell-derived cardiomyocytes using a multi-electrode array system
Kanda, Y. / Yamazaki, D. / Kurokawa, J. / Inutsuka, T. / Sekino, Y. | 2016
201
Multi-parametric assessment of cardiomyocyte excitation-contraction coupling using impedance and field potential recording: A tool for cardiac safety assessment
Zhang, X. / Guo, L. / Zeng, H. / White, S. L. / Furniss, M. / Balasubramanian, B. / Lis, E. / Lagrutta, A. / Sannajust, F. / Zhao, L. L. | 2016
217
Use of FDSS/μCell imaging platform for preclinical cardiac electrophysiology safety screening of compounds in human induced pluripotent stem cell-derived cardiomyocytes
Zeng, Haoyu / Roman, Maria I. / Lis, Edward / Lagrutta, Armando / Sannajust, Frederick | 2016
223
Safety pharmacology studies using EFP and impedance
Obergrussberger, A. / Juhasz, K. / Thomas, U. / Stölzle-Feix, S. / Becker, N. / Dörr, L. / Beckler, M. / Bot, C. / George, M. / Fertig, N. | 2016
233
A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel
Li, Zhihua / Dutta, Sara / Sheng, Jiansong / Tran, Phu N. / Wu, Wendy / Colatsky, Thomas | 2016
240
Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging
Dempsey, G. T. / Chaudhary, K. W. / Atwater, N. / Nguyen, C. / Brown, B. S. / McNeish, J. D. / Cohen, A. E. / Kralj, J. M. | 2016
251
An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel
Crumb, W. J. / Vicente, J. / Johannesen, L. / Strauss, D. G. | 2016
263
Specific prediction of clinical QT prolongation by kinetic image cytometry in human stem cell derived cardiomyocytes
Pfeiffer, Emily R. / Vega, Raquel / McDonough, Patrick M. / Price, Jeffrey H. / Whittaker, Ross | 2016
274
EEG in non-clinical drug safety assessments: Current and emerging considerations
Authier, S. / Delatte, M. S. / Kallman, M. J. / Stevens, J. / Markgraf, C. | 2016
286
CNS safety pharmacology: A focus on cognitive functions
Hernier, Anne Marie / Froger-Colléaux, Christelle / Castagné, Vincent | 2016
295
Drug discrimination: A versatile tool for characterization of CNS safety pharmacology and potential for drug abuse
Swedberg, Michael D.B. | 2016
306
Functional neurotoxicity evaluation of noribogaine using video-EEG in cynomolgus monkeys
Authier, S. / Accardi, M. V. / Paquette, D. / Pouliot, M. n. / Arezzo, J. / Stubbs, R. J. / Gerson, R. J. / Friedhoff, L. T. / Weis, H. | 2016
313
The “induced hyperactivity” test for the de-risking of potential off-target activity of antihypertensive drugs
Himmel, H. M. / Hoffmann, M. | 2016
323
Frequency, types, severity, preventability and costs of Adverse Drug Reactions at a tertiary care hospital
Geer, M.I. / Koul, P.A. / Tanki, S.A. / Shah, M.Y. | 2016
335
Abstracts from the SPS Meeting Presentations, September 2015
| 2016
335
Evaluation and comparison of drug discrimination assessments with cocaine, amphetamine, desipramine, and morphine of male and female rats
Toot, Jonathan / Bennett, Matthew / Hackman, Michelle / Coffee, Matthew / Fennell, Bryan / Loris, Sara / Neely, Aaron / Atterson, Philip | 2016
335
Bioanalytical analysis of plasma cocaine exposure in a preliminary self-administration study utilizing different concentrations of cyclodextrin
Toot, Jonathan / Donegan, Mike / Orens, Paula / Gibbs, Amber / Neely, Aaron / Bennett, Matt / Boggs, Jason / Atterson, Philip | 2016
335
Auditory brainstem response evaluations in cynomolgus macaques: Considerations for anesthesia and waveform data collection and analysis
Abernathy, M. / Yoder, J. / Brian, W. / Richardson, J. / Tapp, R. / McComb, M. / Gauvin, D. / Baird, T. | 2016
336
Neurobehavioral endpoints in non-human primates integrated in toxicology studies
Blanchard, Rose-Hélène / Ponchet-Lac, Anna / Lebatard, Martine / Boixel, Christophe / Mazelin-Winum, Ludmilla / Magnon, Martine / Perrin, Corine / Truphémus, Patricia / Mathieu-Kia, Anne-Marie / Caron, Alexis | 2016
336
The assessment of single-housed vs. pair-housed rats on the Irwin test
Coffee, M. / Shaffer, J. / Adkins, J. / Atterson, P. | 2016
336
Evaluation of gross behavioral and physiological status following administration of a psychostimulant and sedative using a functional observational battery assessment adapted for trained cynomolgus monkeys
Gayheart-Walsten, P. / Baublits, J. / Love, S. / Botchway, A. | 2016
337
Challenges in detection of premonitory electroencephalographic (EEG) changes of drug-induced seizure using a non-human primate EEG telemetry model
Shiotani, Motohiro / Nagano, Norihiro / Ishikawa, Akiyoshi / Sakai, Keita / Yoshinaga, Takashi / Kato, Hiroshi / Teramoto, Tetsuyuki / Furuya, Yoshiaki / Sawada, Kohei | 2016
337
Developing a heat map for CNS profiling based on the Irwin test
de Ron, P. / Martin, F. / da Costa, A. N. / Valentin, J. P. | 2016
337
Effects of different vehicles used in preclinical studies on the neurobehavioral profile and general activity of Sprague Dawley rats
de Ron, P. / Berwaer, M. / Briône, W. / Delaunois, A. / Valentin, J. P. / da Costa, A. N. | 2016
338
Irwin/FOB tests for CNS safety assessment: What are we doing?
Heers, C. / van Amsterdam, C. / Habermann, C. / Schauerte, H. / van der Linde, H. / Himmel, H. / Traebert, M. / Dinklo, T. | 2016
338
Rodent Big Brother: A home cage automated behavioural monitoring system for safety pharmacology and toxicology studies
Tse, Karen / Rimmer, Victoria / Grant, Claire / Simpson, David / Klein, Stephanie / Armstrong, J. Douglas / Lukins, Tim / Chartsias, Agisilaos / O'Callaghan, Emma / Sillito, Rowland et al. | 2016
338
Development and evaluation of a Middle Ear PinPort™ for use in otic histology studies
Tapp, R. / McComb, M. / Cole, P. / Sweet, J. / Gesamen, J. / Tawoda, L. / May, J. / Gauvin, D. / Baird, T. | 2016
338
Critical role for drug discrimination studies in the assessment of abuse liability of novel compounds
Swedberg, Michael | 2016
339
Is manual patch clamp still the gold standard assay for ion channels?
Ballini, E. / Carignani, C. / Bettini, E. / Pilla, M. | 2016
339
Exploring temperature-dependence of hERG channel kinetics using sine wave voltage protocols
Beattie, Kylie / Melgari, Dario / Hancox, Jules / Mirams, Gary | 2016
339
Simulating the effect of anti-diabetic drugs on ATP-sensitive potassium (KATP) channels inhibition in a human cardiac cell model (ORd)
Abbasi, Mitra / Polak, Sebastian | 2016
340
Optimization of optical imaging of cardiac tissue slices as a tool in safety pharmacology
Bollensdorff, C. / Wang, K. / Mu-u-min, R. / Sathappan, A. / Terrar, D. / Yacoub, M. | 2016
340
Bridging functional and structural cardiotoxicity assays using human stem cell-derived cardiomyocytes for a more comprehensive risk assessment
Clements, Mike / Millar, Val | 2016
340
LPS-induced cytokine storm produces QTc prolongation which can be prevented by an anti-inflammatory eutectic blend
Bouchard, Annie / Sordillo, Peter / Helson, Lawrence / Shopp, George / Baillargeon, Sabrina / Shaw, Walter / Salvail, Dany | 2016
341
Use of high throughput electric field stimulation (EFS) coupled with intracellular Ca2+ kinetics measurements on iPSC-derived cardiomyocytes
Kato, N. / Yamamoto, S. / Ito, T. / Matsubara, M. / Du, S. / Kataoka, T. / Iwase, F. / Kettenhofen, R. / von Haniel, F. / d’Angelo, J. M. | 2016
341
Variability in cardiac ion channel assays: A major challenge for CiPA paradigm implementation
Delaunois, A. / Colomar, A. / Valentin, J. P. | 2016
341
Inducible CaV1.2 cell line optimized for automated patch clamp assays
Danker, T. / Frey, M. / Guenther, E. | 2016
341
Mitogen activated kinase kinase 7 is involved in Sunitinib induced myocardial injury
Cooper, Samantha / Maddock, Helen / Hussain, Afthab / Sandhu, Hardip | 2016
342
An integrative biophysical model linking changes in protein function to emergent cellular phenotypes in left ventricular myocytes
Fernandez-Chas, M. / Niederer, S. A. | 2016
342
Complementary automated patch clamp, extracellular field potential and impedance recordings of iPSCs: Safety screening tool box for the future
Dragicevic, Elena / Becker, Nadine / Stölzle-Feix, Sonja / Thomas, Ulrich / Juhasz, Krisztina / Doerr, Leo / Rapedius, Markus / Nicolini, Anthony / Millard, Daniel / Beckler, Matthias et al. | 2016
342
Electrophysiologic actions of diverse CIPA compounds on Cor.4U cardiomyocytes
Gibson, John / Yue, Yimei / Li, Ping / Luermann, Gregory | 2016
343
Comparison of ion-channel data between physiological and room temperature for predicting drug-induced proarrhythmia
Katayama, Y. / Izumi, T. / Tomizawa, S. / Yamaguchi, M. / Kanno, A. | 2016
343
Analysis of field potential from hiPS-derived cardiomyocytes with pharmacological tools: Quantitative correlations with preclinical and clinical endpoints
Momtaz, Abdelhaq / Rousseau, Emilie / Carriot, Thierry / Chantoiseau, Céline / Hoët, Delphine / Guillon, Jean-Michel | 2016
343
Cell-specific mathematical models of cardiac electrophysiology
Johnstone, R. / Bardenet, R. m. / de Boer, T. / Gavaghan, D. / Davies, M. / Polonchuk, L. / Mirams, G. | 2016
344
Identification of CV liabilities in the xCELLigence system using human iPS-derived cardiomyocytes
Kazusa, K. / Watanabe, Y. / Nagata, K. / Sato, Y. / Fujimori, C. / Shirakawa, T. / Okada, A. | 2016
344
Developing a package of in vitro human cardiac ion channel assays to predict clinical arrhythmia risk
Kirby, Robert / Tang, Raymond / Webdale, Louise / Ridley, John / Rogers, Marc | 2016
344
The late sodium current participates in repolarization of hiPSC-derived cardiac myocytes
Pourier, Marc / Gibson, John / Luerman, Greg / Fedida, David | 2016
344
Updating probabilistic assessment of proarrhythmia liability with in silico action potential modeling
Leishman, D. | 2016
345
In silico prediction of drug effects on human ventricular electrophysiology using the Virtual Assay software and comparison to in vitro data
Passini, E. / Britton, O. / Lu, H. R. / Gallacher, D. J. / Rohrbacher, J. / An, H. / Bueno-Orovio, A. / Rodriguez, B. | 2016
345
Vanoxerine: A case study supporting quantitative profiling for assessing cardiac risk
Obejero-Paz, Carlos / Bruening-Wright, Andrew / Kramer, James / Tatalovic, Milos / Dittrich, Howard / Brown, Arthur | 2016
345
CiPA validation of moxifloxacin as a positive control to assess cardiac risk
Obejero-Paz, Carlos / Bruening-Wright, Andrew / Kramer, James / Brown, Arthur | 2016
346
Detection of hERG-trafficking in vitro: A comparison of functional and protein expression methods
Qu, Y. / Crumb, W. / Vargas, H. | 2016
346
Novel assessment of cardiomyocyte functions with hybrid MEA-impedance technology on CardioExcyte96
Polonchuk, Liudmila / Thomas, Ulrich / Davies, Mark / Sanchez, Ruben Alvarez / Schuler, Franz / Singer, Thomas / Stoelzle_Feix, Sonja | 2016
346
Comprehensive in vitro proarrythmic evaluation of cardiomyocytes using a multi-electrode array
Renganathan, Muthukrishnan / Benjamin, Chris / Wei, Haiyang | 2016
347
Comparison of HERG ion channel effects in HEK cells and action potential duration in human iPSC cardiomyocytes
Saxena, P. / Hortigon-Vinagre, M. P. / Costa, A. / Timin, E. / Beyl, S. / Baburin, I. / Smith, G. L. / Hering, S. | 2016
347
Biophysical and pharmacological characterization of the CiPA ion channel panel and iPSC cardiomyocytes using automated patch-clamp
Scheel, O. / Frech, S. / Amuzescu, B. / Crumb, W. / Roberts, M. / Knott, T. | 2016
347
Improved functional maturation of human induced pluripotent stem cell (hiPSC) derived ventricular cardiomyocytes in vitro: Multi-electrode array (MEA) based electrophysiological characterization
Vlaming, M. / Stevenhagen, F. / de Korte, T. / Langenberg, K. / Dunska, M. / Tertoolen, L. / Mummery, C. / Grandela, C. / Braam, S. | 2016
348
To sum or not to sum: How to assess torsadogenic potential of combination of drugs and their active metabolites—In vitro assessment with loratadine and desloratadine as the exemplary drugs
Wiśniowska, B. / Badyra, B. / Lisowski, B. / Polak, S. | 2016
348
Assessment of the electromechanical window of human IPSC-derived cardiomyocytes and its modulation by compounds affecting cardiac function
Zhang, X. / Xi, B. / Abassi, Y. | 2016
348
Evaluation of acute and chronic effects of kinase inhibitors on electrical and contractile activity of human iPSC-derived cardiomyocytes
Zhang, Xiaoyu / Xi, Biao / Abassi, Yama | 2016
349
What are the challenges and opportunities ahead of any regulatory requirements for in silico cardiac pro-arrhythmia prediction?
Davies, M. / Wang, K. / Caruso, A. / Mirams, G. / Noble, D. / Walz, A. / Lave, T. / Schuler, F. / Singer, T. / Polonchuk, L. | 2016
349
Computational models of doxorubicin mitochondria cardiotoxicity
de Oliveira, B. / Niederer, S. | 2016
349
Presence of neuromuscular and pulmonary deficits in a mouse model of Pompe disease
Dalton, Jill / Abernathy, Matthew / May, Jonelle / Harter, Marci / Baird, Theodore | 2016
350
Predicting drug-induced arrhythmia using afterdepolarisations
McMillan, Beth / Gavaghan, David J. / Mirams, Gary R. | 2016
350
Calcium channel blocker increases the anticancer activity of temozolomide by inhibiting autocrine VEGF signaling
Hanif, Farina / Perveen, Kahkashan / Malhi, Saima Mahmood / Simjee, Shabana Usman | 2016
350
Comparison of four in silico models to predict cardiac action potential effects and proarrhythmia liability
Delaunois, Annie / Colomar, Aurore / Valentin, Jean-Pierre | 2016
350
Decreased ejection fraction induced by a MEK inhibitor in spontaneously hypertensive and Wistar rats: Reversibility following co-administration of lisinopril
Ju, Haisong / Zhao, Shufang / Martin, Lori / Wolak, Eileen / Hahn, Suzette / Shenoy, Neeta / Chandra, Sudeep / Friedrichs, Greg / Spence, Stan | 2016
351
Cardiac safety assessment of drugs using three-dimensional heart simulator
Okada, J. i. / Yoshinaga, T. / Kurokawa, J. / Washio, T. / Furukawa, T. / Sawada, K. / Sugiura, S. / Hisada, T. | 2016
351
Zero-magnesium model of seizure like events and anticonvulsant potential of SK-channel agonists in vitro
Raza, M. L. / Heinemann, U. | 2016
351
Towards unravelling the mechanism of cardiotoxicity of citalopram: Utilisation of mechanistic cardiac electrophysiology modelling with the Simcyp cardiac safety simulator (CSS) to explore various hypotheses
Patel, Nikunjkumar / Jamei, Masoud / Polak, Sebastian | 2016
352
Can late sodium current inhibition attenuate QT prolonging effects caused by hERG blockers in in silico models
Rohrbacher, J. / Damiano, B. P. / Teisman, A. / Gallacher, D. J. | 2016
352
A heart compartmental model for the prediction of cardiac amitriptyline concentration
Tylutki, Zofia / Jornil, Jakob / Polak, Sebastian | 2016
352
A holistic approach to the safety assessment of exploratory drug targets
Venhorst, J. / Rankouhi, T. R. / Verschuren, L. / van Someren, E. P. / Kuper, F. C. / Wolterbeek, A. P. / van de Brug, F. J. / Folkertsma, S. / Krul, C. A. | 2016
353
Identifying site-specific molecular signatures for sub-acute drug induced kidney injury
Snelling, Sara / Dremier, Sarah / De Ron, Pierrette / Glineur, Stephanie / Da Costa, André | 2016
353
Prediction of clinical risks by analysis of preclinical and clinical adverse events
Clark, Matthew | 2016
353
Systems Pharmacology based approach utilized for prediction of the cardiac consequences of drug–drug interactions
Wiśniowska, B. / Badyra, B. / Lisowski, B. / Polak, S. | 2016
354
Off-target cardiac Na-channel inhibition in preclinical and clinical development—A case study
Deurinck, M. / Pruimboom, I. / Ju, H. / Dumotier, B. / Traebert, M. | 2016
354
Myocardial electrotonic coupling modulates repolarization heterogeneities in vivo: Implications for the assessment of pro-arrhythmic liabilities in vitro and in silico
del Rio, Carlos / Hamlin, Robert / Billman, George | 2016
354
Recent cardiac ion channel data helped to better understand the QT prolongation/Torsades de Pointes risk of hydroxyzine (Atarax®), a first generation antihistamine
Delaunois, Annie / Colomar, Aurore / Peters, Christopher / Schlit, Anne-Françoise / Valentin, Jean-Pierre | 2016
355
Inter-study variability and translational value of preclinical exposure-QTc predictions—A pharmacokinetic/pharmacodynamic (PK/PD) meta-analysis
Gotta, V. / Cools, F. / van Ammel, K. / Gallacher, D. J. / Visser, S. A. / Sannajust, F. / Morissette, P. / Danhof, M. / van der Graaf, P. H. | 2016
355
Translational prediction of sensitivity to hERG-mediated QTc-prolongation using a systems pharmacology model
Gotta, V. / Cools, F. / van Ammel, K. / Gallacher, D. J. / Visser, S. A. / Sannajust, F. / Morissette, P. / Danhof, M. / van der Graaf, P. H. | 2016
355
Bayesian-hierarchical pharmacokinetic/pharmacodynamic (PK/PD) model to characterize the exposure-QT effect relationship for decision making in early drug development
Dubois, Vincent F.S. / Boulton, Muriel / Bursi, Roberta | 2016
355
Inclusion of neurobehavioural and respiratory safety pharmacology endpoints in the 4-week rat general toxicology studies
Fasdelli, Nicola / Pecoraro, Michela / Pilla, Maria | 2016
356
Proactively developing assay schemes based on an understanding of the goal of testing and the nature of the safety endpoint
Leishman, D. | 2016
356
Comparison of binding and functional data on a set of safety-related GPCRs
Jolas, Thierry / Migeon, Jacques / Fouchaq, Benoit | 2016
356
Mechanistic investigation into a delayed onset QTc prolongation
Gray, Kelly / Pointon, Amy / Rose, Alexandra / Philp, Karen / Moors, Jackie / Skinner, Matthew / Bridgland-Taylor, Matthew / Harmer, Alex | 2016
357
Applying probabilistic 'weight-of-evidence' assessments to diverse safety endpoints
Leishman, Derek | 2016
357
Translation to human: Not just a simple correlation exercise between preclinical and clinical data: A qualitative/semi-quantitative analysis
Loenders, Brigitte / Van Ammel, Karel / Gallacher, David J. | 2016
357
The non-invasive translational biomarker — Index of cardiac electrophysiological balance (iCEB) predicts potential risk of cardiac arrhythmias in preclinical models and in patients: Superior to current biomarkers such as QT?
Lu, Hua Rong / Robyns, Tomas / Nuyens, Dieter / Janssens, Stefan / Yan, Gan-Xin / Teisman, Ard / Gallacher, David J. | 2016
358
Dual inhibition of VEGF and DLL4 ameliorates anti-DLL4 cardiac endothelial hypertrophy in cynomolgus monkeys
Meisner, Rene / Argast, Gretchen / Liu, Yu-Wang / Wallace, Breanna / Wang, Min / Kapoun, Ann / Hoey, Tim | 2016
358
Biomarkers of hypercoagulability in a rat sepsis-induced model of non-overt disseminated intravascular coagulation (DIC)
Brooks, M. B. / Turk, J. R. / Fishman, C. E. / Besteman, E. G. / Wilson, D. W. / Schultze, A. E. / Pierson, J. B. / Parish, S. / Pugsley, M. K. | 2016
358
Patient-specific QT risk assessment: Case study of an oncology agent and an anti-emetic
Pollard, Chris / Philp, Karen / Easter, Alison / Moors, Jackie / Prior, Helen | 2016
359
An in silico PBPK-PD coupled approach to assess zolpidem effect on pre-clinically and clinically measured cardiac repolarisation parameters in the absence and presence of a circadian model of plasma ion concentration
Small, B. G. / Jamei, M. / Rostami-Hodjegan, A. / Polak, S. | 2016
359
Assessment of cardiac biomarkers in patients undergoing coronary artery bypass grafting (CABG) surgery
Sabah, Enas / Kamal, Amang / Al-Saffar, Ahmad | 2016
359
Incorporation of safety pharmacology endpoints in toxicology studies in monkeys
Qu, Linhai / Wu, Rui / McPherson, Sue / Jin, Yi | 2016
359
Left ventricular pressure may improve predictivity of preclinical cardiovascular assays to clinical outcomes
Roche, Brian / Brandon Borders, R. / Appleby, Cory / Kieper, Jason / Landis, Kasey / Kearney, Ken / Adkins, James / Vidmar, Tom / Atterson, Phil | 2016
360
Translation: Lessons learned of a quantitative analysis with 5 clinically tested compounds. Just a walk in the park… or a shot in the dark?
Van Ammel, K. / Loenders, B. / Gallacher, D. | 2016
360
Pharmacovigilance study of iron chelators in thalassemic patients
Usta, C. k. / Kurtoğlu, E. / Bedel, A. / Kurtoğlu, A. e. | 2016
360
In vitro to clinical translation to improve proarrhythmic risk assessment
Strauss, D. / Vicente, J. / Mason, J. / Crumb, W. / Hosseini, M. / Stockbridge, N. / Johannesen, L. | 2016
361
Importance of parameter control in cardiac models for robust pro-arrhythmic risk prediction
Wang, K. / Davies, M. / Caruso, A. / Mirams, G. / Noble, D. / Walz, A. C. / Lavé, T. / Schuler, F. / Singer, T. / Polonchuk, L. | 2016
361
Tiron offers protection from doxorubicin induced myocardial injury
Chiuzbaian, Oana / Gharanei, Mayel / Mee, Christopher / Maddock, Helen / Hatch, Ellen | 2016
361
Considerations for in vitro systems to reflect in vivo toxicities to facilitate drug development
Zabka, T. / Kim, A. / Uppal, H. / Kauss, A. / Dhawan, P. / Liederer, B. / Lin, T. / McCray, B. / Nguyen, T. / Chou, C. | 2016
362
Ex vivo model to investigate anticancer drug-induced chronic cardiotoxicity
Ducroq, J. / Didier, H. l. / Salvetat, C. l. / Le Grand, M. | 2016
362
An in vitro assay for assessing cardiac contractility effects of test compounds using the rat myocardial work loop assay
Gharanei, Mayel / Wallis, Rob / Babba, Maryam / Maddock, Helen | 2016
362
Work-loop assay to predict inotropic drug effects of checkpoint kinase inhibitors
Gharanei, M. / Wallis, R. / Babba, M. / Varcianna, A. / Maddock, H. | 2016
363
PK and cardiac assessment in rats administered doxorubicin
Henderson, K. / Ross, J. / Borders, B. / Gibbs, S. / Hong, P. / Wood, B. / Vinci, T. / Roche, B. / Smith, J. | 2016
363
Use of the human trabeculae muscle work loop assay to predict adverse drug effects on heart contractility
Gharanei, Mayel / Wallis, Rob / Babba, Maryam / Maddock, Helen | 2016
364
Development of an in vitro rat phrenic nerve–diaphragm muscle preparation
Roof, Steve / del Rio, Carlos / Patil, Popat / Strauch, Steven / Hamlin, Robert | 2016
364
Preclinical assessment of neuronal network activity and compound-dependent seizure liability using an MEA based in vitro platform
Cato, M. / Shen, F. / Smith, R. / Bradley, J. / Murphy, D. / Chaudhary, K. | 2016
364
Kinetic image cytometry and high content analysis assay of neurotoxicity
McDonough, Patrick / Basa, Ranor / Cai, Beibei / Batchelder, Erika / Feng, Shuyun / Price, Jeffery | 2016
364
Comparative analysis of data sciences international PhysioTel™ D70 and PhysioTel™ digital telemetry platforms
Kearney, Kenneth / Appleby, Cory / Kieper, Jason / Atterson, Philip | 2016
365
Left ventricular pressure (LVP) and contractility in freely-moving rats: The application of marginal distribution analysis
Authier, S. / Abtout, S. / Bujold, K. / Ascah, A. / Pouliot, M. / Troncy, E. / Forster, R. / Pugsley, M. K. | 2016
365
Addition of left ventricular pressure measurement to a cardio-respiratory model, using telemetry and plethysmography in the conscious rat
Beaudoin, S. / Williams, C. / Melliti, K. / Meecham, K. / Milner, V. | 2016
365
Comparison of left ventricular contractility to RR interval relationship in freely-moving rats, dogs and monkeys
Authier, Simon / Abtout, Samir / Ascah, Alexis / Pouliot, Mylene / Bujold, Kim / Troncy, Eric / Forster, Roy / Pugsley, Michael K. | 2016
366
The tilt test in non-human primate (NHP) using manual restraint: An improved method to investigate orthostatic hypotension
Betat, Anne-Marie / Delpy, Eric / Bureau, Marie / Veillard, Jérémie / La Rochelle, Christophe Drieu | 2016
366
Alterations of the PR interval in chronically instrumented dogs and monkeys
Dalton, Jill / Abernathy, Matthew / O'Donohue, Kyle / Gesaman, Janelle / Harter, Marci / May, Jonelle / Baird, Theodore | 2016
366
Evaluation of apnea in the dog: A guidance on preclinical evaluations and correlation to clinical sleep apnea scoring
Renninger, Jonathan / DiPasquale, Jonathan / Murphy, Dennis | 2016
366
Comparison of dog and guinea pig cardiovascular telemetry
Cseko, C. / Komlódi, Z. / Makó, v. / Balázs, O. | 2016
367
QT interval correction for drug-induced changes in body temperature in dogs
El Amrani, A. I. / El Amrani, F. / Loriot, S. / Singh, P. / Forster, R. | 2016
367
Investigation of hemodynamic changes induced by CompoundX in Wistar Han rats
Tang, H. M. / Flaherty, M. / Aibo, D. I. / Walker, D. / Shenoy, N. / Vostiar, I. / Stiehl, D. / Ju, H. / Friedrichs, G. | 2016
367
How preclinical neurobehavioural data can predict drug related effects on cardiovascular parameters
Garbati, Nicoletta / Fasdelli, Nicola / Pilla, Maria / Maraschiello, Ciriaco | 2016
368
Why may the ECG vary so much when a “Modified Lead II” is taken by telemetry?
Hamlin, R. | 2016
368
Assessment of electrocardiography (ECG) parameter variability when building ECG template libraries
Ross, R. / Kremer, J. / Aschcroft-Hawley, K. / Michael Foley, C. / Osinski, M. / Carneal-Frazer, N. | 2016
368
Incorporation of safety pharmacology endpoints in the toxicological assessment of a potential diagnostic positron emission tomography (PET) imaging agent
Hirani, Ella / Daalsgard, Grethe / Hoppmann, Susan / Evans, Paul | 2016
369
A comparison of baseline heart rates, left ventricular and systolic pressure in group housed versus single housed beagle dogs and the effects of housing on sensitivity to detect changes in contractility following Pimobendan administration
Sadekova, Nataliya / Boudreau, Ghislaine / Norton, Kevin | 2016
369
Microsampling—A Refinement to the Home Cage Rat Telemetry Model
Philp, Karen / Moors, Jackie / Skinner, Matt / MacDonald, Ruth / Ngeny, Maryann / Redfern, William | 2016
369
Evaluation of minimally invasive blood pressure telemetry devices in conscious Beagle dogs
Skinner, M. / Milne, A. / Grant, C. / Meyer, O. / Stanton, A. / Sutherland, J. / Moors, J. / Bradley, A. | 2016
370
The electromechanical window (EMw): A heart-rate independent biomarker for delayed repolarization of the heart
Waiz, David / Roberts, Sonia / Jenni, Roland / Greiter-Wilke, Andrea | 2016
370
Evaluation of Digital Implantable Telemetry in Multiple Social Housing Paradigms for Cynomolgus Monkey
Tichenor, Stephen / Regalia, Douglas / Holzgrefe, Henry / Lilly, Brittany / Wilcox, Angela / Kaiser, Robert | 2016
370
Evaluation of conscious free moving dual pressure telemetered guinea pigs as a model for safety pharmacology study
Ueyama, Y. / Mittelstadt, S. / del Rio, C. / Roof, S. / Youngblood, B. / Wallery, J. / Hamlin, R. | 2016
371
Physiological differences between brachycephalic and non-brachycephalic dogs after 6min walking test at high altitude
Arango, S. / Durán, A. / Florez, S. n. / Vargas-Pinto, P. | 2016
371
Assessing cardiotoxicity in the zebrafish embryo
Alzualde, A. / Holgado, O. / Bertran, E. / Geiter-Wilke, A. / Muriana, A. / Roberts, S. | 2016
371
Comparison of alternative in vivo ECG endpoints for arrhythmia prediction
Wu, X. / Payseur, J. / Murphy, D. / Rossman, E. | 2016
371
Echocardiography in a toxicology setting
Engwall, Michael / Vargas, Hugo | 2016
372
Promising approach for the preclinical assessment of cardiac risks using left ventricular pressure–volume loop analyses in anesthetized monkeys
Ishizaka, T. / Yoshimatsu, Y. / Maeda, Y. / Takasaki, W. / Chiba, K. / Mori, K. | 2016
372
A model of acute congestion with progressive induction of pulmonary edema in sheep with chronic ischemic left-ventricular dysfunction: Preliminary results
Geist, Gail E. / del Rio, Carlos / Youngblood, Bradley / Render, Kevin / Ueyama, Yukie / Hamlin, Robert | 2016
372
Plasma miR-208: A robust early biomarker of cardiac drug induced injury in rats
Glineur, S. / de Ron, P. / Hanon, E. / Valentin, J. P. / Dremier, S. / da Costa, A. N. | 2016
373
Dronedarone prevents atrial fibrillation in dog model of sustained atrial fibrillation
Saengklub, Nakkawee / Limprasutr, Vudhiporn / del Rio, Carlos / Hamlin, Robert L. / Kijtawornrat, Anusak | 2016
373
Selective actions of lead acetate, aluminum and cadmium sulfate in the corpus cavernosum and their effects on erectile function in rats
Saad, Evan / Senbel, Amira / Taha, Safaa / Fouad, Hosny | 2016
373
Inotropy and chronotropy screens in engineered human myocardium
Meyer, T. / Tiburcy, M. / Zimmermann, W. H. | 2016
374
Effects of body weight on electrophysiology, hemodynamics and plasma exposure in anesthetized guinea-pigs: An impact on preclinical safety margin analysis
Urmaliya, V. / Lauryssen, L. / Daems, H. / Verrelst, J. / Teisman, A. / Gallacher, D. J. | 2016
374
Effects on iCEB and EMw after levcromakalim infusions in normal and reduced coronary flow anesthetized dog models
van der Linde, H. / Van Deuren, B. / Somers, Y. / Teisman, A. / Gallacher, D. | 2016
374
6min walking test in healthy dogs and in dogs with pulmonary hypertension (before and after sildenafil) at high altitude
Vargas-Pinto, P. / Tapasco, L. / Betancourt, E. a. / Carrero, M. / Bechara, E. a. / Pedraza-Toscano, A. | 2016
375
Characterization of canine models of heart failure with reduced and preserved ejection fraction
Youngblood, B. / del Rio, C. / Render, K. / Geist, B. / Ueyama, Y. / Wallery, J. / Hamlin, R. | 2016
375
The predictive value of the rodent neurofunctional assessment for commonly reported adverse events in phase I clinical trials
Mead, Andrew / Amouzadeh, Hamid / Chapman, Kathryn / Ewart, Lorna / Giarola, Alessandra / Jackson, Samuel / Jarvis, Philip / Jordaan, Pierre / Redfern, Will / Traebert, Martin et al. | 2016
375
CNS safety of spadin
Champeroux, P. / Maleysson, V. / Bracq, E. / Maurin, A. / Mazella, J. / Heurteaux, C. / Borsotto, M. / Richard, S. | 2016
376
Enhance in pentylenetetrazole or maximal electro shock induced seizures in experimental models of ulcerative colitis: An interplay of altered cytokines level, adhesion molecules, blood brain barrier disruption
Medhi, Bikash / Sewal, Rakesh K. / Modi, Manish / Saikia, Uma Nahar / Chakrabarti, Amitava | 2016
376
NeuroSafe: A human integrated in vitro Neurotoxicity Safety Platform
Redaelli, L. / Maresca, G. / Tremolada, S. / Kuhn, C. / Brioschi, M. / Hess, D. / Guenther, E. / Scarabottolo, L. | 2016
376
Utility of an in vitro platform to assess neuronal toxicity using human iPSC-derived neurons
Misner, Dinah / Snyder, Chelsea / Ngo, Tin / Yu, Lanlan / Stagg, Nicola / Staflin, Karin | 2016
376
Use of stem cell derived peripheral neurons as a model of chemotherapeutic induced peripheral neuropathy
Delaney, S. / Wing, C. / Favre, N. / Luerman, G. / Dolan, E. | 2016
377
How to improve the respiratory safety evaluation: Impact of animal welfare?
Dudzicki, Anne / Lemos-de-Andrade, Edineia / Momtaz, Abdelhaq / Baudet, Henri-Michel / Guillon, Jean-Michel / Boixel, Christophe | 2016
377
Respiratory measurements in rats as indicator of adverse respiratory reactions to inhaled drugs
Larsson, M. H. / Gustavsson, M. / Kärrman-Mårdh, C. / Kirk, S. / Öhlin, S. / Österlund, A. / Åberg, P. / Edmunds, N. / Conlon, K. | 2016
377
Treatment for established hypoxia-semaxanib induced pulmonary arterial hypertension in rats: Riociguat and sildenafil improve pulmonary hemodynamics and right ventricular hypertrophy using a disease intervention strategy
Hock, Franz / Huang, Jinbao / Janssen, Douglas / Zammit, Melissa / Neves, Liomar / Senese, Peter / Gralinski, Michael | 2016
378
Global Cross-company Data-sharing on the Housing of Non-rodents During the Recording of Cardiovascular Telemetry Data on Safety Pharmacology and Toxicology Studies
Bottomley, A. / Prior, H. / Cordes, J. | 2016
378
Effect of a HIF-prolyl hydroxylase inhibitor on aortic pressure, heart rate and peak right ventricular pressure in rats exposed to acute hypoxia
Kohrs, Loren / Renninger, Jon / Murphy, Dennis | 2016
378
Simultaneous evaluation of cardiovascular and respiratory functions in the conscious dog
Rompion, S. / Guillaume, P. / Goineau, S. / Froget, G. | 2016
379
Safety assessment of a formulation for 68Ga-DOTATOC (68Ga-edotreotide or 68Ga-DOTA0-Tyr3-octreotide) preparation: Case studies in rats and rabbits
Chicco, D. / Orlandi, F. / Venturella, S. / Di Manno, P. / Manno, R. A. | 2016
379
Drugs withdrawn from the market over the last 50years: Contribution of adverse effects within the sphere of influence of safety pharmacology
Redfern, Will | 2016
379
Assessment of HER-2/neu gene amplification and expression as a biomarker for radiotherapy and hormonal treated breast cancer patients in Upper Egypt
Esmat, M. / AbdelWanis, M. / Mosad, E. / EL-maghraby, T. / Othman, A. | 2016
380
Comprehensive assessment of multiple induced pluripotent stem cell-derived cardiomyocyte cell lines with microelectrode arrays and voltage sensitive dyes
Blinova, Ksenia / Stohlman, Jayna / Vicente, Jose / Chan, Dulciana / Hortigon, Maria / Rodriguez, Victor Zamora / Smith, Godfrey / Ross, James / Brock, Mathew / Chvatal, Stacie et al. | 2016
380
Simulated micro-electrode array recordings from stem cell-derived cardiomyocytes
Bowler, L. / Harris, K. / Gavaghan, D. / Mirams, G. | 2016
380
How much of a cardiomyocyte can we get from stem cells? Setting up metrics for cardiac cell models
Chabria, Mamta / Hoflack, Jean-Christophe / Badi, Laura / Flint, Nicholas / Burcin, Mark / Graf, Martin / Singer, Thomas / Alvarez-Sanchez, Ruben / Schuler, Franz / Polonchuk, Liudmila | 2016
381
A highly scalable embryonic stem cell platform for in vitro genetics of drug response
Bergseid, J. / Joshi-Barr, S. / Page, L. / Carlo, A. / Brown, S. / Choi, T. | 2016
381
Impedance based Assay on iPS cardiomyocytes: An efficient way of discriminating between cardioactive and non cardioactive drugs
Colomar, A. / Haen, L. / Toussaint, G. l. / Loïodice, S. / Kopp, B. / Atienzar, F. / Valentin, J. P. | 2016
381
Cardiotoxicity testing in human iPSC-derived cardiomyocytes for the CiPA pilot study using all-optical electrophysiology
Dempsey, G. / Atwater, N. / Nguyen, C. | 2016
382
Assessing the predictivity of a human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) multielectrode array (MEA) assay for preclinical cardiac electrophysiology safety screening
Harris, K. / Graham, S. / Sridhar, A. / Louttit, J. | 2016
382
Early screening for cardiac arrhythmic liabilities: Comparison of a new assay measuring Ca2+ transients in human stem cell-derived cardiomyocytes to the more traditional assays (isolated guinea-pig right atrium model and HERG assay)
Hermans, A. N. / Geyskens, D. / Rohrbacher, J. / Lu, H. R. / Lammens, L. / Gallacher, D. J. | 2016
382
Human iPS-derived cardiac myocyte-fibroblast 3D co-cultures: A predictive in vitro model to assess drug-induced contractile and metabolic liabilities
Goßmann, M. / Palm, T. / Kettenhofen, R. / Bohlen, H. / Lu, H. R. / Gallacher, D. J. / Artmann, G. / Epple, M. / Artmann, A. l. | 2016
383
Usefulness of motion vector prediction system for evaluating drug-induced functional changes of human induced pluripotent stem cell-derived cardiomyocytes
Honda, Masaki / Ishitomi, Akihiro / Okai, Yoshiko / Kitamura, Tetsuo / Isobe, Takehito / Matsune, Keiko / Araki, Sei-ichi | 2016
383
Characterization of the physiology and cardiotoxicity of cardiac 3D microtissues of hiPSC-derived cardiomyocytes (hiPSC-CMs)
Hortigon-Vinagre, M. P. / Zamora, V. / Alageswaran, V. / Craig, D. / Fluri, D. / Bruton, F. L. / Agarkova, I. / Kelm, J. M. / Craig, M. A. / Smith, G. L. | 2016
383
Image-based evaluation of contractile characteristics of hiPS-CMs: A tool for pre-clinical cardiovascular drug discovery
Huang, M. / Shi, H. / Zhu, J. / Levesque, P. | 2016
384
Human iPSC-derived Cor.4U cardiomyocytes as a predictive tool for different comprehensive in vitro proarrhythmia assay endpoints
Kettenhofen, R. / Duenbostell, A. / Luerman, G. / Li, P. / Yue, Y. / Bronson, J. / Horai, H. / D'Angelo, J. M. / Niedereichholz, T. / Gibson, J. K. | 2016
384
Assessment of drug-induced QT prolongation using human iPS cell-derived mature cardiomyocytes
Kanda, Yasunari / Li, Min / Ashihara, Takashi / Sekino, Yuko / Furukawa, Tetsushi / Kurokawa, Junko | 2016
384
CSAHi study: Evaluation of MED64 multi-electrode array in combination with human iPS cell-derived cardiomyocytes to predict drug-induced QT prolongation and arrhythmia
Kitaguchi, Takashi / Moriyama, Yuta / Miyamoto, Norimasa / Taniguchi, Tomohiko / Ojima, Atsuko / Ando, Hiroyuki / Uda, Takaaki / Otabe, Koji / Oguchi, Masao / Shimizu, Shigekazu et al. | 2016
385
An in vitro assessment of delayed HDAC inhibitor-induced cardiotoxicity in human induced pluripotent stem cell-derived cardiomyocytes
Kopljar, Ivan / Vlaminckx, Eddy / Lu, Hua Rong / Gallacher, David | 2016
385
Could in vitro animal assays be replaced by human stem cell-based assays for drug-induced cardiac risks: Beyond QT-prolongation/CIPA?
Lu, Hua Rong / Hermans, An / Kopljar, Ivan / Rohrbacher, Jutta / Teisman, Ard / Gallacher, David J. | 2016
385
CSAHi study: Usability assessment of multi-electrode array in combination with human iPS cell-derived cardiomyocytes for prediction of drug-induced QT prolongation and arrhythmia — Multi Channel Systems (MEA60 and MEA2100)
Kunimatsu, T. / Nozaki, Y. / Honda, Y. / Watanabe, H. / Yamanishi, A. / Nogawa, H. / Endo, H. / Saiki, S. / Nagasawa, C. / Nakamori, C. | 2016
386
Action potential duration and proarrhythmia assay by kinetic image cytometry in hiPS-cardiomyocytes for the FDA/HESI CiPA initiative
Pfeiffer, Emily / Whittaker, Ross / Hilton, Jeffrey / Ingermanson, Randy / Price, Jeffrey | 2016
386
Assessment of reverse use-dependent blocking actions of dofetilide in stimulated human induced pluripotent stem cell derived (hiPSC) cardiomyocytes
Shi, Hong / Huang, Minxue / Levesque, Paul | 2016
386
Humoral factor from rodent astrocytes promoted the synaptic transmission and augmented synchronized population bursts in human induced pluripotent stem cell-derived neurons
Miyamoto, N. / Sawada, K. | 2016
386
iNCENS (iPSC non-clinical experiments for nervous system): A project to establish the CNS safety pharmacological evaluation to predict risks of cognitive impairment and epilepsy by in vitro use of human induced pluripotent stem cell-derived neurons
Sato, K. / Takahashi, K. / Shigemoto-Mogami, Y. / Shimizu, H. / Ikegaya, Y. / Koyama, R. / Hiragi, T. / Miyamoto, N. / Shirao, T. / Sekino, Y. | 2016
387
Comprehensive in vitro cardiac safety assessment using human stem cell technology—Overview of CSAHi HEART initiative
Takasuna, Kiyoshi / Asakura, Keiichi / Araki, Seiichi / Ando, Hiroyuki / Kazusa, Katsuyuki / Kitaguchi, Takashi / Kunimatsu, Takeshi / Suzuki, Shinobu / Miyamoto, Norimasa | 2016
387
Differential effects of astemizole on the neurite growth and synaptogenesis of neurons
Shirao, Tomoaki / Ishizauka, Yuta / Hanamura, Kenji / Koganezawa, Noriko / Ootsu, Mao / Yamazaki, Hiroyuki | 2016
387
Single site CiPA cardiomyocyte pilot study results on two MEA platforms with two hiPSC sources
Shi, H. / Huang, M. / Lewen, G. / Levesque, P. | 2016
388
Organ-on-Chip: A synthetic mimic for human myocardium
van Meer, Berend / Ribeiro, Marcelo / Tertoolen, Leon / Birket, Matthew / Passier, Robert / Mummery, Christine | 2016
388
The unbound concentration of multimodal drugs in the assay medium used in the multi-electrode array system for cardiac risk assessment with iPS cell-derived cardiomyocytes
Yoshinaga, Takashi / Shinkyo, Raku / Kikuchi, Kiyomi / Taniguchi, Tomohiko / Sekino, Yuko / Sawada, Kohei | 2016
388
Electrophysiological characterization of iCell2 hiPSC derived cardiomyocytes: The new generation of CDI hiPSC-CMs
Taylor, A. E. / Zamora, V. / Hortigon-Vinagre, M. P. / Allan, A. / Burton, F. L. / Anson, B. D. / Craig, M. A. / Smith, G. L. | 2016
389
A comparison of drug-induced changes in electrical excitability using optogenetic sensors and conventional field stimulation in hiPS-derived cardiomyocytes (hiPSC-CMs)
Zamora, Victor / Hortigon-Vinagre, Maria / Allan, Andrew / Lu, Hua Rong / Burton, Francis / Gallacher, David / Smith, Godfrey | 2016
389
Use of inulin and PAH for renal drug safety evaluations in conscious dogs
Abernathy, Matthew / Dalton, Jill / Harter, Marci / Gauvin, David / Baird, Theodore | 2016
389
Gastroinstestinal motility: Motility and motor migrating complex (MMC) evaluations in rats, dogs and non-human primates
Authier, Simon / Tang, Hai-Ming / Abtout, Samir / Ascah, Alexis / Pouliot, Mylene / Bujold, Kim / Troncy, Eric / Pugsley, Michael K. / Forster, Roy | 2016
390
Citrulline — A Potential Translational Safety Biomarker for the Small Intestine
Pipp, F. / Hellmann, J. r. / Poetzsch, S. / Hewitt, P. / Schmitt, M. | 2016
390
A HESI consortium update on cardiac contractility endpoints
Pugsley, Michael K. / Guth, Brian / Chiang, Alan / Doyle, Jennifer / Engwall, Mike / Guillon, Jean-Michel / Hoffmann, Peter / Koerner, John / Mittelstadt, Scott / Ottinger, Sean et al. | 2016
390
Cloud analysis of rat cardiac contractility: Determining changes in left ventricular dP/dt without correcting for heart rate
Brandon Borders, R. / Pittman, Rhea / Roche, Brian | 2016
IFC
Editorial Board
| 2016

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