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Historical Perspective

Factors Affecting Metabolism

Biotransformations in Drug Metabolism

A Comprehensive Picture of Biotransformation in Drug Discovery

<fc><fi>In Vivo</fi></fc> Drug Metabolite Kinetics

<fc>LC‐MS</fc> / <fc>MS</fc> ‐Based Proteomics Methods for Quantifying Drug‐Metabolizing Enzymes and Transporters

Mass Spectrometry

Accelerating Metabolite Identification Mass Spectrometry Technology Drives Metabolite Identification Studies Forward

Role of Structural Modifications of Drug Candidates to Enhance Metabolic Stability

Drug Design Strategies: Role of Structural Modifications of Drug Candidates to Improve <fc>PK</fc> Parameters of New Drugs

Chemical Structural Alert and Reactive Metabolite Concept as Applied in Medicinal Chemistry to Minimize the Toxicity of Drug Candidates

Studies of Reactive Metabolites using Genotoxicity Arrays and Enzyme/ <fc>DNA</fc> Biocolloids – 2021

Enzyme Inhibition

Xenobiotic Receptor‐Mediated Gene Regulation in Drug Metabolism and Disposition

Characterization of Cytochrome <fc>P450</fc> Mechanism Based Inhibition

An Introduction to Metabolic Reaction‐Phenotyping

Epigenetic Regulation of Drug‐Metabolizing Enzymes in Cancer

Epigenetic Regulation of Drug Transporters in Cancer

The Role of Drug Metabolism in Toxicity

Allergic Reactions to Drugs

Chemical Mechanisms in Toxicology

Role of Bioactivation Reactions in Chemically Induced Nephrotoxicity

Mapping the Heterogeneous Distribution of Cancer Drugs by Imaging Mass Spectrometry

Systemic Metabolomic Changes Associated with Chemotherapy: Role in Personalized Therapy

Metabolic Reprogramming in Cancer

Case Study: Metabolism and Reactions of Alkylating Agents in Cancer Therapy

Rewiring of Drug Metabolism and Its Cross‐talk with Metabolic Reprogramming in Cancer

Principles of Drug Metabolism and Interactions in Cardio‐Oncology

Index

Front Matter