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Dried Blood Spots [2014]

1
Overview of the History and Applications of Dried Blood Samples
16
Dried Blood Spot Cards
21
Dried Blood Spot Sample Collection, Storage, and Transportation
32
Dried Blood Spot Specimens for Polymerase Chain Reaction in Molecular Diagnostics and Public Health Surveillance
40
Application of Enzyme Immunoassay Methods Using Dried Blood Spot Specimens
53
Applications of Dried Blood Spots in Newborn and Metabolic Screening
76
Dried Blood Spots for Use in HIV‐Related Epidemiological Studies in Resource‐Limited Settings
95
Use of Dried Blood Spot Samples in HCV‐, HBV‐, and Influenza‐Related Epidemiological Studies
114
Applications of Dried Blood Spots in General Human Health Studies
130
Applications of Dried Blood Spots in Environmental Population Studies
140
The Use of Dried Blood Spots and Stains in Forensic Science
151
Pharmaceutical Perspectives of Use of Dried Blood Spots
160
Punching and Extraction Techniques for Dried Blood Spot Sample Analysis
168
Considerations in Development and Validation of LC‐MS/MS Method for Quantitative Analysis of Small Molecules in Dried Blood Spot Samples
179
Challenges and Experiences with Dried Blood Spot Technology for Method Development and Validation
188
Clinical Implications of Dried Blood Spot Assays for Biotherapeutics
195
Potential Role for Dried Blood Spot Sampling and Bioanalysis in Preclinical Studies
202
Clinical and Bioanalytical Evaluation of Dried Blood spot Sampling for Genotyping and Phenotyping of Cytochrome p450 Enzymes in Healthy Volunteers
216
Application of Dried Blood Spot Sampling in Clinical Pharmacology Trials and Therapeutic Drug Monitoring
229
Automation in Dried Blood Spot Sample Collection, Processing, and Analysis for Quantitative Bioanalysis in Pharmaceutical Industry
235
Beyond Dried Blood Spots—Application of Dried Matrix Spots
243
Direct Analysis of Dried Blood Spot Samples
298
Paper Spray Ionization for Direct Analysis of Dried Blood Spots
314
Direct Solvent Extraction and Analysis of Biomarkers in Dried Blood Spots Using a Flow‐Through Autosampler
325
Development of Biomarker Assays for Clinical Diagnostics Using a Digital Microfluidics Platform
332
Applications and Chemistry of Cellulose Papers for Dried Blood Spots
344
Derivatization Techniques in Dried Blood Spot Analysis
355
Index
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Front Matter
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