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Muscle Aging, Inclusion‐Body Myositis and Myopathies [2012]

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Aging of the Human Neuromuscular System: Pathological Aspects
33
Aging of the Human Neuromuscular System: Clinical Considerations
55
Aging of the Human Neuromuscular System: Patient Vignettes
81
Mitochondrial Changes in Aging with Particular Reference to Muscle, and Possible Clinical Consequences
89
Protein Degradation in Aging Cells and Mitochondria: Relevance to the Neuromuscular System
97
Human Muscle Protein Metabolism in Relation to Exercise and Aging: Potential Therapeutic Applications
109
Pathogenesis of Sporadic Inclusion‐Body Myositis: Role of Aging and Muscle‐Fiber Degeneration, and Accumulation of the Same Proteins as in Alzheimer and Parkinson Brains
146
Inflammatory and Autoimmune Features of Inclusion‐Body Myositis
159
Sporadic Inclusion‐Body Myositis: Clinical Symptoms, Physical Findings, and Diagnostic Investigations
168
Pathologic Diagnostic Criteria of Sporadic Inclusion‐Bodyc Myositis and Hereditary Inclusion‐Body Myopathy Muscle Biopsies
175
Function and Mutations of the GNE Gene Leading to Distal Myopathy with Rimmed Vacuoles/Hereditary Inclusion‐Body Myopathy, Animal Models, and Potential Treatment
191
GNE Myopathy (Hereditary Inclusion‐Body Myopathy/Distal Myopathy with Rimmed Vacuoles): Clinical Features and Epidemiology
199
Consequences of the hereditary inclusion‐body myopathy‐characteristic GNE mutations on muscle proteins in vivo and in vitro
206
Function and Structure of <fi>VCP</fi> Mutations Leading to Inclusion‐Body Myopathy Associated with Paget Disease of Bone and Frontotemporal Dementia
219
Clinical Spectrum of VCP Myopathy, Paget Disease, and fronTotemporal Dementia: Experimental Models and Potential Treatments
230
<fi>Drosophila</fi> and Mouse Models of Hereditary Myopathy Caused by Mutations in VCP/p97
241
Index
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Colour Plates
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Front Matter
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