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Oral Bioavailability [2011]

1
Barriers to Oral Bioavailability—An Overview
7
Physicochemical Characterization of Pharmaceutical Solids
21
Solubility of Pharmaceutical Solids
39
<fi>In Vitro</fi> Dissolution of Pharmaceutical Solids
51
Biological and Physiological Features of the Gastrointestinal Tract Relevant to Oral Drug Absorption
63
Absorption of Drugs via Passive Diffusion and Carrier‐Mediated Pathways
77
<fi>In Vitro</fi>–<fi>In Vivo</fi> Correlations of Pharmaceutical Dosage Forms
91
Drug Metabolism in Gastrointestinal Tract
111
Efflux of Drugs via Transporters—The Antiabsorption Pathway
127
Liver Drug Metabolism
145
Protein Binding of Drugs
167
Urinary Excretion of Drugs and Drug Reabsorption<link></link>
183
Pharmacokinetic Behaviors of Orally Administered Drugs
221
Effects of Food on Drug Absorption
233
Drug–Drug Interactions and Drug–Dietary Chemical Interactions
253
Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rats, Dogs, and Humans
267
Amino Acid Drug Transporters
291
Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide‐Based Pharmaceuticals
309
Organic Anion and Cation Drug Transporters
329
Gastric Retentive Drug Delivery Systems
343
Lipid‐Based and Self‐Emulsifying Oral Drug Delivery Systems
355
Prodrug Strategies to Enhance Oral Drug Absorption
371
Oral Delivery of Protein/Peptide Therapeutics
381
ABC Transporters in Intestinal and Liver Efflux
401
Interplay between Efflux Transporters and Metabolic Enzymes
413
Regulatory Considerations in Metabolism‐ and Transporter‐Based Drug Interactions
431
Caco‐2 Cell Culture Model for Oral Drug Absorption
443
MDCK Cells and Other Cell‐Culture Models of Oral Drug Absorption
461
Intestinal Perfusion Methods for Oral Drug Absorptions
475
Liver Perfusion and Primary Hepatocytes for Studying Drug Metabolism and Metabolite Excretion
493
<fi>In vivo</fi> Methods for Oral Bioavailability Studies
505
Determination of Regulation of Drug‐Metabolizing Enzymes and Transporters
519
Computational and Pharmacoinformatic Approaches to Oral Bioavailability Prediction
535
Index
541
Wiley Series in Drug Discovery and Development
c1
Color Plates
i
Frontmatter
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