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Oral Bioavailability [2011]
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Barriers to Oral Bioavailability—An Overview
- 7
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Physicochemical Characterization of Pharmaceutical Solids
- 21
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Solubility of Pharmaceutical Solids
- 39
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<fi>In Vitro</fi> Dissolution of Pharmaceutical Solids
- 51
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Biological and Physiological Features of the Gastrointestinal Tract Relevant to Oral Drug Absorption
- 63
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Absorption of Drugs via Passive Diffusion and Carrier‐Mediated Pathways
- 77
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<fi>In Vitro</fi>–<fi>In Vivo</fi> Correlations of Pharmaceutical Dosage Forms
- 91
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Drug Metabolism in Gastrointestinal Tract
- 111
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Efflux of Drugs via Transporters—The Antiabsorption Pathway
- 127
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Liver Drug Metabolism
- 145
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Protein Binding of Drugs
- 167
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Urinary Excretion of Drugs and Drug Reabsorption<link></link>
- 183
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Pharmacokinetic Behaviors of Orally Administered Drugs
- 221
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Effects of Food on Drug Absorption
- 233
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Drug–Drug Interactions and Drug–Dietary Chemical Interactions
- 253
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Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rats, Dogs, and Humans
- 267
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Amino Acid Drug Transporters
- 291
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Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide‐Based Pharmaceuticals
- 309
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Organic Anion and Cation Drug Transporters
- 329
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Gastric Retentive Drug Delivery Systems
- 343
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Lipid‐Based and Self‐Emulsifying Oral Drug Delivery Systems
- 355
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Prodrug Strategies to Enhance Oral Drug Absorption
- 371
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Oral Delivery of Protein/Peptide Therapeutics
- 381
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ABC Transporters in Intestinal and Liver Efflux
- 401
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Interplay between Efflux Transporters and Metabolic Enzymes
- 413
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Regulatory Considerations in Metabolism‐ and Transporter‐Based Drug Interactions
- 431
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Caco‐2 Cell Culture Model for Oral Drug Absorption
- 443
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MDCK Cells and Other Cell‐Culture Models of Oral Drug Absorption
- 461
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Intestinal Perfusion Methods for Oral Drug Absorptions
- 475
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Liver Perfusion and Primary Hepatocytes for Studying Drug Metabolism and Metabolite Excretion
- 493
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<fi>In vivo</fi> Methods for Oral Bioavailability Studies
- 505
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Determination of Regulation of Drug‐Metabolizing Enzymes and Transporters
- 519
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Computational and Pharmacoinformatic Approaches to Oral Bioavailability Prediction
- 535
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Index
- 541
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Wiley Series in Drug Discovery and Development
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Color Plates
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Frontmatter