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BACE [2010]
- 1
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BACE, APP Processing, and Signal Transduction in Alzheimer's Disease
- 15
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Identification of BACE as a Target in Alzheimer's Disease
- 35
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BACE Biological Assays
- 59
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Peptidic, Peptidomimetic, and HTS‐Derived BACE Inhibitors
- 107
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Fragment‐Based Approaches for Identification of BACE Inhibitors
- 123
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Structure‐Based Design of BACE Inhibitors: Technical and Practical Aspects of Preparation, 3‐Dimensional Structure, and Computational Analysis
- 159
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Pharmacological Models for Preclinical Testing: From Mouse to Dog to Nonhuman Primates
- 177
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Adsorption, Distribution, Metabolism, Excretion (ADME), Efficacy, and Toxicology for BACE Inhibitors
- 197
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Clinical Trials for Disease‐Modifying Drugs Such as BACE Inhibitors
- 217
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Future Strategies for Development of Novel BACE Inhibitors: Anti‐APP β‐Site Antibody and APP Binding Small Molecule Approaches for Alzheimer's Disease
- 235
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Afterword
- 243
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Index
- c1
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Color Plates
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Frontmatter