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BACE [2010]

1
BACE, APP Processing, and Signal Transduction in Alzheimer's Disease
15
Identification of BACE as a Target in Alzheimer's Disease
35
BACE Biological Assays
59
Peptidic, Peptidomimetic, and HTS‐Derived BACE Inhibitors
107
Fragment‐Based Approaches for Identification of BACE Inhibitors
123
Structure‐Based Design of BACE Inhibitors: Technical and Practical Aspects of Preparation, 3‐Dimensional Structure, and Computational Analysis
159
Pharmacological Models for Preclinical Testing: From Mouse to Dog to Nonhuman Primates
177
Adsorption, Distribution, Metabolism, Excretion (ADME), Efficacy, and Toxicology for BACE Inhibitors
197
Clinical Trials for Disease‐Modifying Drugs Such as BACE Inhibitors
217
Future Strategies for Development of Novel BACE Inhibitors: Anti‐APP β‐Site Antibody and APP Binding Small Molecule Approaches for Alzheimer's Disease
235
Afterword
243
Index
c1
Color Plates
i
Frontmatter
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