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Label‐Free Technologies for Drug Discovery [2011]

1
The Revolution of Real‐Time, Label‐Free Biosensor Applications
27
Design and Implementation of Vertically Emitting Distributed Feedback Lasers for Biological Sensing
41
SPR Screening of Chemical Microarrays for Fragment‐Based Discovery
57
The CellKey® System: A Label‐Free Cell‐Based Assay Platform for Early Drug Discovery Applications
71
Dynamic and Label‐Free Cell‐Based Assays Using the xCELLigence System
83
Selecting the Best HTS Hits to Move Forward: ITC Ligand Binding Characterization Provides Guidance
101
Incorporating Transmitted Light Modalities into High‐Content Analysis Assays
111
Nonradioactive Rubidium Efflux Assay Technology for Screening of Ion Channels
125
Expanding the Scope of HTMS Methods
141
A Novel Multiplex SPR Array for Rapid Screening and Affinity Determination of Monoclonal Antibodies: The ProteOn XPR36 Label Free System: Kinetic Screening of Monoclonal Antibodies
155
Biophysics/Label‐Free Assays in Hit Discovery and Verification
171
Harnessing Optical Label‐Free on Microtiter Plates for Lead Finding: From Binding to Phenotypes
189
Use of Label‐Free Detection Technologies in the Hit‐to‐Lead Process: Surface Optical Detection of Cellular Processes
205
Cellular Screening for 7TM Receptors Using Label‐Free Detection
223
Novartis Evaluation of the ForteBio Octet RED: A Versatile Instrument for Direct Binding Experiments
241
The Pyramid™ Approach to Fragment‐Based Biophysical Screening
255
Characterisation of Antibodies Against the Active Conformation of G<sub>αi1</sub> Using the SRU‐BIND® Label‐Free Detection System
269
SPR‐Based Direct Binding Assays in Drug Discovery
283
Kinetic Binding Mechanisms: Their Contribution to an Optimal Therapeutic Index
303
ITC: More Than Just Binding Affinities
313
Index
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Front Matter
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