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Kinase Inhibitor Drugs [2009]

1
Discovery and Development of Sunitinib (SU11248): A Multitarget Tyrosine Kinase Inhibitor of Tumor Growth, Survival, and Angiogenesis
41
Tykerb Discovery: A Dual EGFR and ERBB2 Tyrosine Kinase Inhibitor
57
Discovery of Pazopanib: A Pan Vascular Endothelial Growth Factor Kinase Inhibitor
79
Road to ABT‐869: A Multitargeted Receptor Tyrosine Kinase Inhibitor
113
Discovery of Motesanib
131
Discovery of Brivanib Alaninate: A Dual Vascular Endothelial Growth Factor and Fibroblast Growth Factor Receptor Inhibitor
167
Structure‐Based Design and Characterization of Axitinib
203
Road to PD0325901 and beyond: The MEK Inhibitor Quest
229
Discovery of Allosteric MEK Inhibitors
253
Discovery of MK‐0457 (VX‐680)
281
Discovery of PHA‐739358
309
Discovery of AZD1152: A Selective Inhibitor of Aurora‐B Kinase with Potent Antitumor Activity
333
Case Study of Aurora‐A Inhibitor MLN8054
351
Discovery of GSK461364: A Polo‐Like Kinase 1 Inhibitor for the Treatment of Cancer
365
Pharmacogenomics of Dasatinib (Sprycel™)
403
Practical Use of Computational Chemistry in Kinase Drug Discovery
433
Approaches to Kinase Homology Modeling: Successes and Considerations for the Structural Kinome
461
Fragment‐Based Drug Discovery of Kinase Inhibitors
485
Protein Kinase Structural Biology: Methods and Strategies for Targeted Drug Discovery
501
Index
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Color Plates
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Frontmatter
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