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Kinase Inhibitor Drugs [2009]
- 1
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Discovery and Development of Sunitinib (SU11248): A Multitarget Tyrosine Kinase Inhibitor of Tumor Growth, Survival, and Angiogenesis
- 41
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Tykerb Discovery: A Dual EGFR and ERBB2 Tyrosine Kinase Inhibitor
- 57
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Discovery of Pazopanib: A Pan Vascular Endothelial Growth Factor Kinase Inhibitor
- 79
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Road to ABT‐869: A Multitargeted Receptor Tyrosine Kinase Inhibitor
- 113
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Discovery of Motesanib
- 131
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Discovery of Brivanib Alaninate: A Dual Vascular Endothelial Growth Factor and Fibroblast Growth Factor Receptor Inhibitor
- 167
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Structure‐Based Design and Characterization of Axitinib
- 203
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Road to PD0325901 and beyond: The MEK Inhibitor Quest
- 229
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Discovery of Allosteric MEK Inhibitors
- 253
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Discovery of MK‐0457 (VX‐680)
- 281
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Discovery of PHA‐739358
- 309
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Discovery of AZD1152: A Selective Inhibitor of Aurora‐B Kinase with Potent Antitumor Activity
- 333
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Case Study of Aurora‐A Inhibitor MLN8054
- 351
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Discovery of GSK461364: A Polo‐Like Kinase 1 Inhibitor for the Treatment of Cancer
- 365
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Pharmacogenomics of Dasatinib (Sprycel™)
- 403
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Practical Use of Computational Chemistry in Kinase Drug Discovery
- 433
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Approaches to Kinase Homology Modeling: Successes and Considerations for the Structural Kinome
- 461
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Fragment‐Based Drug Discovery of Kinase Inhibitors
- 485
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Protein Kinase Structural Biology: Methods and Strategies for Targeted Drug Discovery
- 501
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Index
- c1
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Color Plates
- i
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Frontmatter