Organic Process Research & Development
Die Inhaltsverzeichnisse werden automatisch erzeugt und basieren auf den im Index des TIB-Portals verfügbaren Einzelnachweisen der enthaltenen Beiträge. Die Anzeige der Inhaltsverzeichnisse kann daher unvollständig oder lückenhaft sein.
Inhaltsverzeichnis
- 2121
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Payloads for Antibody–Drug ConjugatesGoundry, William R. F. / Parker, Jeremy S. et al. | 2022
- 2124
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Process Development and GMP Production of a Conjugate Warhead: Auristatin F‑HPA-Ala/TFA (XMT-1864/TFA)Conlon, Patrick R. / Gurijala, Venu Reddy / Kaufman, Michael et al. | 2022
- 2138
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Stereoselective Synthesis of a Tubulysin Core for Antibody–Drug Conjugate StudiesZheng, Bin / Ortiz, Adrian / Guerrero, Carlos A. et al. | 2022
- 2145
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Fit-for-Purpose Synthesis of an Aza-Cryptophycin Analogue as the Payload for an Antibody–Drug ConjugateBendelac, Audrey / Benedetti, Françoise / Doublet-Decabras, Valerie et al. | 2022
- 2155
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Development of Dual Practical Manufacturing Routes to Cognate Pyrrolobenzodiazepine-Based Linker-DrugsKoenig, Stefan G. / Angelaud, Rémy / Crittenden, Christopher M. et al. | 2022
- 2176
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Importance of Green and Sustainable Chemistry in the Chemical IndustryColberg, Juan / Kuok (Mimi) Hii, King / Koenig, Stefan G. et al. | 2022
- 2179
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Some Items of Interest to Process R&D Chemists and EngineersGuizzetti, Sylvain / Schwindeman, James A. / Daniels, David S. B. et al. | 2022
- 2190
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Fixed Bed Continuous Hydrogenations in Trickle Flow Mode: A Pharmaceutical Industry PerspectiveMasson, Edward / Maciejewski, Erin M. / Wheelhouse, Katherine M. P. et al. | 2022
- 2224
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Highlights of the Recent Patent Literature: Focus on Asymmetric OrganocatalysisHughes, David L. et al. | 2022
- 2240
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Pd-Catalyzed Cross-Couplings: On the Importance of the Catalyst Quantity Descriptors, mol % and ppmHorbaczewskyj, Christopher S. / Fairlamb, Ian J. S. et al. | 2022
- 2270
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Direct Synthesis of Methylchlorosilanes: Catalysts, Mechanisms, Reaction Conditions, and Reactor DesignsZhang, Pan / Zhang, Dan / Dong, Jipeng et al. | 2022
- 2281
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Recent Advances in Non-Precious Metal CatalysisWu, Hao / Qu, Bo / Nguyen, Thach et al. | 2022
- 2311
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Review on Synthetic Approaches toward Rivaroxaban (Xarelto), an Anticoagulant DrugMladentsev, Dmitry Y. / Kuznetsova, Ekaterina N. / Skvortsova, Maria N. et al. | 2022
- 2330
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Process Intensive Synthesis of Propofol Enabled by Continuous Flow ChemistryVinet, Laurent / Di Marco, Lorenzo / Kairouz, Vanessa et al. | 2022
- 2337
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Development and Scale-Up of a Copper-Catalyzed Sulfamidation Coupling ReactionAdlington, Neil K. / Siedlecki, Paul S. / Derrick, Ian et al. | 2022
- 2351
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Development of Enzymatic Variants for the Synthesis of Bioresorbable PolyestersAlmeida, Beatriz C. / Figueiredo, Pedro R. / Dourado, Daniel F.A.R. et al. | 2022
- 2364
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Strategy for Non-Seeded Crystallization of Slow-to-Crystallize Compounds with an Oscillatory Dynamic Baffled Crystallizer: A Case Study with α‑Lactose MonohydrateDarmali, Christine / Liu, Yiqing Claire / Mansouri, Shahnaz et al. | 2022
- 2377
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Simple Methods to Predict Particle Size for Growth-Only Systems Undergoing One or More Temperature CyclesPatience, Daniel B. / Irdam, Erwin / Madden, Nicole et al. | 2022
- 2392
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Practical Ferrioxalate Actinometry for the Determination of Photon Fluxes in Production-Oriented Photoflow ReactorsVandekerckhove, Bavo / Piens, Nicola / Metten, Bert et al. | 2022
- 2403
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Optimized Method to Achieve 1‑Hydroxy-5-aminotetrazole (HAT)Yocca, Sebastian / Piercey, Davin G. et al. | 2022
- 2407
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Development of a Practical Process for the Large-Scale Preparation of the Chiral Pyridyl-Backbone for the Crabtree/Pfaltz-Type Iridium Complex Used in the Industrial Production of the Novel Fungicide InpyrfluxamJones, Michelle / Harris, Dave / Struble, Justin et al. | 2022
- 2415
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Cost-Efficient, Multigram Scalable Synthesis of Shelf-Stable Electrophilic (Phenylsulfonyl)difluoromethylating ReagentsNobile, Enzo / Hébert, Jean-Pierre / Castanheiro, Thomas et al. | 2022
- 2423
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Kilo-Scale Electrochemical Oxidation of a Thioether to a Sulfone: A Workflow for Scaling up ElectrosynthesisBottecchia, Cecilia / Lehnherr, Dan / Lévesque, François et al. | 2022
- 2438
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Development of a New Synthetic Route of the Key Intermediate of IrbesartanChen, Zhaohang / Guo, Yuanxia / Niu, Huilong et al. | 2022
- 2447
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Reactor Design for the Direct Electrosynthesis of PeriodateArndt, Sebastian / Rücker, Richard / Stenglein, Andreas et al. | 2022
- 2456
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Minimizing Material Consumption in Flow Process Research and Development: A Novel Approach Toward Robust and Controlled Mixing of ReactantsHaber, Julien / Ausserwoeger, Hannes / Lehmann, Claudio et al. | 2022
- 2464
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Suppression of Simultaneous Fmoc-His(Trt)-OH Racemization and N α‑DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid Activation Strategy in Peptide SynthesisYang, Yi / Hansen, Lena / Baldi, Alberto et al. | 2022
- 2475
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An Alternative Route to the Anticancer Agent: 2‑Fluorofucose from Readily Available L‑(−)Rhamnose and Mechanistic Insights into a Zinc/Ammonium Iodide-Mediated Elimination ReactionYousefi, Roozbeh / Paul-Gorsline, Bradley J. / Soltani, Omid et al. | 2022
- 2483
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Development of an Optimized Synthetic Process for an Antiobesity Drug Candidate (S-234462) Featuring Mild Chlorination of Benzoxazolone and In Situ IR Monitoring of a Mitsunobu ReactionOda, Shinichi / Fukui, Yuki / Hozumi, Yasuyuki et al. | 2022
- 2492
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Accelerated Multiphosphorylated Peptide SynthesisGrunhaus, Dana / Molina, Estefanía Rossich / Cohen, Roni et al. | 2022
- 2498
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Tunable Microwave Flow System for Scalable Synthesis of Alkyl Imidazolium-type Ionic LiquidsDomański, Michał / Žurauskas, Jonas / Barham, Joshua P. et al. | 2022
- 2510
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Efficient Synthesis of a Key Intermediate for Moxifloxacin Via Intramolecular Double StereodifferentiationLiao, Shouzhu / Sun, Guodong / Wu, Shuming et al. | 2022
- 2519
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Addition Reaction of Alcohol to Isocyanate Catalyzed by Copper Present in Tap Water: Robust Manufacturing Process of Naldemedine TosylateOda, Shinichi / Masui, Yoshiyuki / Omura, Sohei et al. | 2022
- 2526
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Synthesis of MDM2-p53 Inhibitor BI-0282 via a Dipolar Cycloaddition and Late-Stage Davis–Beirut ReactionRamharter, Juergen / Kulhanek, Michael / Dettling, Maike et al. | 2022
- 2532
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Synthesis of Thiomorpholine via a Telescoped Photochemical Thiol–Ene/Cyclization Sequence in Continuous FlowSteiner, Alexander / Nelson, Ryan C. / Dallinger, Doris et al. | 2022
- 2540
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Corrections to “An Optimized Safe Process from Bench to Pilot cGMP Production of API Eptifibatide Using a Multigram-Scale Microwave-Assisted Solid-Phase Peptide Synthesizer”D’Ercole, Annunziata / Pacini, Lorenzo / Sabatino, Giuseppina et al. | 2022