JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
Die Inhaltsverzeichnisse werden automatisch erzeugt und basieren auf den im Index des TIB-Portals verfügbaren Einzelnachweisen der enthaltenen Beiträge. Die Anzeige der Inhaltsverzeichnisse kann daher unvollständig oder lückenhaft sein.
Inhaltsverzeichnis
- 69
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Methods in safety pharmacology in focusPugsley, M. K. / Gallacher, D. J. / Towart, R. et al. | 2008
- 72
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Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologicsVargas, H. M. / Bass, A. S. / Breidenbach, A. et al. | 2008
- 77
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Safety and secondary pharmacology: Successes, threats, challenges and opportunitiesValentin, J. P. / Hammond, T. et al. | 2008
- 88
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A functional observational battery in non-human primates for regulatory-required neurobehavioral assessmentsGauvin, D. V. / Baird, T. J. et al. | 2008
- 94
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Conscious and anesthetized non-human primate safety pharmacology models: Hemodynamic sensitivity comparisonAuthier, S. / Tanguay, J. F. / Fournier, S. et al. | 2008
- 99
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Benchmarking Safety Pharmacology regulatory packages and best practiceLindgren, S. / Bass, A. S. / Briscoe, R. et al. | 2008
- 110
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Zebrafish assays as early safety pharmacology screens: Paradigm shift or red herring?Redfern, W. S. / Waldron, G. / Winter, M. J. et al. | 2008
- 118
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Heartbeat dynamics in adrenergic blocker treated conscious beagle dogsLi, D. / Chiang, A. Y. / Clawson, C. A. et al. | 2008
- 129
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Safety pharmacology assessment of central nervous system function in juvenile and adult rats: Effects of pharmacological reference compoundsHimmel, H. M. et al. | 2008
- 147
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Measurement of gastrointestinal transit using paracetamol and sulfasalazine as marker compounds in fed conscious dogsSjödin, L. / Visser, S. / Poijes, N. et al. | 2008
- 147
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Age-dependent gender difference in sotalol induced QT-prolongation in the anaesthetised guinea-pigLoenders, B. / Verrelst, J. / Somers, Y. et al. | 2008
- 147
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Continuous gastric pH monitoring in freely moving beagleMilano, S. p. / Baudet, S. p. / Chalencon, E. et al. | 2008
- 148
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An anesthetized rabbit electrophysiology model for cardiovascular liability assessmentSun, H. / Levesque, P. / Li, D. et al. | 2008
- 148
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Maximising the utility of an anaesthetised guinea pig model for screening cardiovascular safety: Thioridazine case studyGates, S. / Bryne, N. / Richardson, J. A. et al. | 2008
- 148
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Comparison of cardiovascular effects in conscious and pentobarbital anesthetized dogsPolakowski, J. / Fryer, R. M. / Gintant, G. A. et al. | 2008
- 148
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Transgenic LQT1 and LQT2 rabbits provide a new model for safety screening for IKr or IKs blocking propensity of drugsOdening, K. E. / Kirk, M. / Lorvidhaya, P. et al. | 2008
- 149
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Electrophysiologic and hemodynamic features in propofol-fentanyl anesthetized and conscious rabbitsLi, D. / Sun, H. / Levesque, P. et al. | 2008
- 149
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KCNA5-deficient mice do not have enhanced arrhythmia susceptibilitySun, H. / Levesque, P. / Li, D. et al. | 2008
- 149
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A novel analysis method for characterising in vitro cardioactive drug effectsBryant, S. / Broadbent, S. / Wyllie, C. et al. | 2008
- 149
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A canine model of relatively sustained atrial fibrillation induced by rapid atrial pacing and phenylephrineKijtawornrat, A. / Roche, B. M. / Lolly, J. L. et al. | 2008
- 150
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Determination of LD50 and assessment of drug induced developmental toxicity in zebrafishMcGrath, P. / Seng, W. L. / Willett, C. et al. | 2008
- 150
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Zebrafish: An automated high content screening platform for safety pharmacologyBarros, T. P. / Reynolds, H. / Clarke, S. et al. | 2008
- 150
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Evaluation of cardiovascular and ECG parameters in the normal, freely moving Göttingen MinipigStubhan, M. / Markert, M. / Mayer, K. et al. | 2008
- 150
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Ferrets: A new cardiovascular telemetry model for early compound development screeningAdams, S. / Bricker, G. / Main, B. et al. | 2008
- 151
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Neurobehavioural assessment in pre-clinical species: Rodents, dogs, mini-pigs and monkeysGiarola, A. / Moscardo, E. / Fasdelli, N. et al. | 2008
- 151
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Evaluation of ethanol interaction potential using preclinical models of rodent behaviour and motor coordinationScatchard, J. / Addley, N. / Knight, T. et al. | 2008
- 151
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Graphical presentation of Irwin test data as an aid to interpretationMoser, P. / Porsolt, R. / Castagné, V. et al. | 2008
- 151
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Original FOB method adapted to safety pharmacologyHoh-Begon, S. / Hennequin, S. / Beaughard, M. l. et al. | 2008
- 152
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Evaluation of fore limb grip strength as part of a modified Irwin testFreichel, C. / Usan, M. / Breidenbach, A. et al. | 2008
- 152
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Noninvasive ECG telemetry using Bluetooth® technology in concious nonhuman primates in a toxicology study settingJenkins, A. C. / Mitchell, A. / Sarazan, R. D. et al. | 2008
- 152
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Validation of an OptoMotry system for measurement of visual acuity in Han Wistar ratsMaung, K. P. / Storey, S. / McKay, J. et al. | 2008
- 152
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Toxicity testing behavior assessment of anticonvulsant fraction isolated from Delphinium specieRaza, M. L. / Zeeshan, M. / Ahmad, M. et al. | 2008
- 153
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Evaluation of long term effects of an intracardiac implant for ECG recording in conscious monkeysArrigoni, C. / Carù, F. / Bonfanti, U. et al. | 2008
- 153
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Detailed evaluation of circadian changes on CV parameters in telemetered dogs important for proper data interpretationD'Aubioul, J. / Cools, F. / Vanlommel, A. et al. | 2008
- 153
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Improved surgical approach for telemetry implantation via intermuscular technique and monitoring of body temperature inMiyamoto, M. / Sheehan, J. / Vessie, S. et al. | 2008
- 153
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Utility of novel electrocardiogram-lead system from cardiac surface using telemetry systems in free-moving dogMatsubara, F. / Tobita, K. / Suzuki, J. et al. | 2008
- 154
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Global gene expression profiling of human embryonic stem cell derived cardiomyocytesSteel, D. M. / Synnergren, J. / Åkesson, K. et al. | 2008
- 154
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Determination of compound kinetic solubility by flow cytometry in support of the automated patch clamp hERG assayGuo, L. / Li, S. / Mouskountakis, J. et al. | 2008
- 154
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Validation of the jacketed, external telemetry JET™ system for monitoring ECGs in non-human primatesSpeece, T. / Deng, M. / Gayheart-Walsten, P. et al. | 2008
- 154
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High dose Dofetilide in conscious dogs; development of full concentration-response relationshipDewhurst, M. / Regan, N. / Pettit, K. et al. | 2008
- 155
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Understanding a hERG anomoly: One class of compounds challenges the theoryBrewer, K. / Doherty, C. / Alden, C. et al. | 2008
- 155
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hERG potency estimation and dose solution analysis: What have we learned?Vargas, H. M. / Qu, Y. et al. | 2008
- 155
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Embryonic chick myocardium as a sensitive model for prediction of drug-induced QT-interval prolongationNamekata, I. / Takahara, A. / Nouchi, H. et al. | 2008
- 155
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Automated patch clamp for temperature controlled hERG compound screeningHaythornthwaite, A. / Brueggemann, A. / Farre, C. et al. | 2008
- 156
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Validation of a voltage-sensitive dye-based method for assessing dog myocyte action potential durationHardy, M. E. / Small, B. G. / Valentin, J. P. et al. | 2008
- 156
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Assessment of airway resistance and compliance in consciousNorton, K. / Wachman, E. / Mason, S. et al. | 2008
- 156
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Transmural repolarization velocity is a reliable index predicting drug torsadogenicity in an isolated rabbit heart modelGuérard, N. / Traebert, M. / Suter, W. et al. | 2008
- 156
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Characterisation of an activator of the hERG-encoded potassium channelBridgland-Taylor, M. H. / Pye, H. / Mannikko, R. et al. | 2008
- 157
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Heart rate correction models to detect QT interval prolongation in novel pharmaceutical developmentMarkert, M. / Shen, R. / Trautmann, T. et al. | 2008
- 157
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Respiratory safety pharmacology: Comparison of conscious beagle dogs and cynomolgus monkey modelsAuthier, S. / Legaspi, M. / Breault, C. et al. | 2008
- 157
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Simultaneous evaluation method for central nervous, cardiovascular and respiratory systems in identical free-moving dogsTomaru, A. / Miyamori, T. / Takahashi, H. et al. | 2008
- 157
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Head-out rat plethysmography with intravenous infusion of test articles: Development and validation of a new methodJenkins, A. C. / Osinski, M. A. / Foley, C. M. et al. | 2008
- 158
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Moxifloxacin: Translating preclinical findings into QT-prolongation detectable in human thorough QT/QTC studiesHoffmann, M. / Himmel, H. M. / Kubitza, D. et al. | 2008
- 158
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Application of modified ECG lead placement technique in rat telemetry safety studies; outcome and potential useDewhurst, M. / Adeyemi, O. / Harris, J. et al. | 2008
- 158
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QA interval, as an index of contractility using telemetric measurement in conscious cynomolgus monkeys (Macaca fascicularis)El-Amrani, F. / Martel, E. / Richard, S. et al. | 2008
- 158
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Multiple mechanisms of QTC shorteningRegan, N. / Sutton, M. R. / Waldron, G. et al. | 2008
- 159
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A comprehensive assessment of drug effects on cardiovascular function in anesthetized beagle dogHamlin, R. L. / Kijtawornrat, A. / Roche, B. et al. | 2008
- 159
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Evaluation of beat-to-beat variability parameters in anaesthetised dogs and guinea pigsSkinner, M. R. / McMahon, N. / Philp, K. et al. | 2008
- 159
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Comparison of anaesthetised and conscious rat model for the early evaluation of myocardial contractilityDelpy, E. / Hirel, R. g. / Infanti, F. et al. | 2008
- 159
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AV block monkey can predict proarrhythmic risk of moxifloxacin: Comparison of the results with those from clinical studySugiyama, A. / Nakamura, Y. / Hoshiai, K. et al. | 2008
- 160
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Cardiovascular safety evaluations assessment in exercise stress and heart failure modelsHassler, C. R. / Coffee, M. / Hawk, M. et al. | 2008
- 160
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Sotalol as positive control for IKr block in HEK-293 cells and for QT prolongation in conscious monkeys and dogsPerego, V. / Arrigoni, C. / Cavazzoli, C. et al. | 2008
- 160
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Heart rate correction of the QT interval: A nonparametric individualized approachGreco, G. / Russu, A. / Arrigoni, C. et al. | 2008
- 161
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Nonclinical to clinical translation for hemodynamic changes - How well do our animal models predict for human?McHarg, A. / Wisialowski, T. / Scatchard, J. et al. | 2008
- 161
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Correction of QT intervals in dogs with tachycardia. Challenge to atropinPehrson, R. / Forsberg, T. / Al-Saffar, A. et al. | 2008
- 161
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Comparison of anesthetic protocols for unconscious cardiovascular safety pharmacologyAuthier, S. / Legaspi, M. / Breault, C. et al. | 2008
- 161
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Potential value of zebrafish (Danio rerio) larvae as a front-loaded in vivo screen to assess safety pharmacology endpoinValentin, J. P. / Waldron, G. / Redfern, W. et al. | 2008
- 162
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High throughput screening of a panel of ion channel expressing cell linesWible, B. A. / Kuryshev, Y. A. / Kirsch, G. E. et al. | 2008
- 162
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Validation of the Dynaflow® temperature control system for the hERG testHaeusermann, F. / Braum, S. / Breidenbach, A. et al. | 2008
- 162
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Effect of pentamidine on QT interval in the conscious guinea-pig and hERG traffickingRobinson, S. / Worton, S. / Simecek, N. et al. | 2008
- 162
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Effects of arsenic trioxide, an inhibitor for hERG channel trafficking, on the electrocardiogram of the guinea pigSakakibara, M. / Sasaki, A. / Tsumura, Y. et al. | 2008
- 163
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Delay of QT prolongation to pharmacokinetics in haloperidolMaekawa, M. / Ishitsuka, T. / Harada, H. et al. | 2008
- 163
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Usefulness of guinea pig Langendorff heart assay for predicting QT prolongatTakagi, K. / Ishitsuka, T. / Asayama, M. et al. | 2008
- 163
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Acute cardioprotective effects of dexrazoxane during doxorubicin perfusion in isolated guinea-pig heartsDucroq, J. / Stucker, O. / Pons-Himbert, C. et al. | 2008
- 164
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Applicarion of isolated heart electrophysiology model for investigative studies of cardiac toxicityLi, D. / Zhu, J. / Shi, H. et al. | 2008
- 164
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Characterisation of an ionworks-based assay for the hKCNQ1/hKCNE1 (IKs) cardiac ion channelBridgland-Taylor, M. H. / Gorvin, C. M. / Ellston, J. M. et al. | 2008
- 164
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Effects of JNJ-17333030, naratriptan and sumatriptan on human isolated coronary arteryWilliams, S. / Sheldrick, B. / Gallacher, D. et al. | 2008
- 164
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Comparison of dog myocytes and purkinje fibres for assessment of drug-induced changes in action potential durationAbi-Gerges, N. / Valentin, J. P. / Pollard, C. E. et al. | 2008
- 165
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Major ion currents except ito are present in the ventricle of the Göttingen minipig heartMow, T. / Arlock, P. / Laursen, M. et al. | 2008
- 165
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Instant cells with high and constant cell quality provide a reliable tool for safety pharmacologyEhnert, C. / Rascher-Eggstein, G. / Scheel, O. et al. | 2008
- 165
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Is Na+ channel the culprit?Qu, Y. / Fang, M. / Torti, V. et al. | 2008
- 165
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Pharmacological characterisation of 9 Single Nucleotide Polymorphisms (SNPS) of the hERG-encoded K channelMannikko, R. / Harmer, A. R. / Overend, G. et al. | 2008
- 166
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GLP validation of a hERG patch clamp assayLautermilch, N. / Wang, S. / Bishop, A. et al. | 2008
- 166
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Implementation of the 3R's in the rat intravenous drug self-administration modelPrice, J. / Hygate, D. / Doris, C. et al. | 2008
- 166
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Evaluation of memory function in rats: A comparison of water maze and object recognition tasksLodiot, A. / Rousseau, P. / Betat, A. M. et al. | 2008
- 166
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Automated patch clamp screening of hERG and other cardiac channels using QPatch16Stevens, E. et al. | 2008
- 167
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How pre-clinical neurobehavioural data can provide safety check point in dose escalation studies in humansGiarola1, A. / Moscardo, E. et al. | 2008
- 167
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Validation of rat behavioural models for the assessment of cannabinoid abuse potentialStaveley, S. M. / O'Connor, E. / Parker, D. et al. | 2008
- 167
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Feasibility of nerve conductance measurements for monitoring peripheral nerve tissue function in cynomolgus monkeysNiehoff, M. / Sternberg, J. / Rensing, S. et al. | 2008
- 167
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Cocaine-, nicotine- and morphine-induced conditioned place preference using an unbiaised, one compartment procedureBertaina-Anglade, V. / la Rochelle, C. D. et al. | 2008
- 168
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Design of a computer sleep-scoring algorithm and validation by testing of flunitrazepam and caffeine on the sleep-wake cycleMaurin, A. / Bracq, E. / Champeroux, P. et al. | 2008
- 168
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Effects of GABAA receptor antagonists in the rat hippocampal brain slice assayEaster, A. / Valentin, J. P. / Pollard, C. E. et al. | 2008
- 168
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Comparison of a hippocampal brain slice and zebra fish assay for assessment of seizure liabilityEaster, A. / Winter, M. / Pollard, C. E. et al. | 2008
- 168
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Development and characterization of in vitro hyperexcitability induction models for use in screening antiepileptic drugsWall, T. / Dalton, J. / Wolfe, M. et al. | 2008
- 169
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Neurological assessment of a novel ampa antagonist using Maximal Electroshock (MES) and Pentylenetetrazol (PTZ) testsElger, B. / Kontenak, M. / Schneider, H. et al. | 2008
- 169
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Zebrafish embryo-larval locomotion as a frontloaded screen for assessing seizure liability during early drug discoveryWinter, M. J. / Redfern, W. / Hayfield, A. et al. | 2008
- 169
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Validation of an optomotor method for assessment of visual function in zebrafish larvaeAlderton, W. K. / Kimber, G. M. / Richards, F. R. et al. | 2008
- 169
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The evaluation of the morris water maze test using intravenously-treated scopolamine in ratsShinohara, A. / Tashibu, H. / Kii, Y. et al. | 2008
- 170
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Possibility of female rabbit model for detecting tdp inducing effect — Comparison with dog AV-B modelAkie, Y. / Saitou, H. / Nagayama, Y. et al. | 2008
- 170
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Echocardiography applications in safety pharmacologyTontodonati, M. / Fasdelli, N. / Dorigatti, R. et al. | 2008
- 170
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Central Nervous System (CNS) effects of psychoactive reference compounds in baby, juvenile, and adult ratsHimmel, H. M. et al. | 2008
- 170
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Cutting edge echocardiographic analyses for the assessment of global and regional myocardial dynamics in the beagle dogTontodonati, M. / Fasdelli, N. / Dorigatti, R. et al. | 2008
- 171
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Comparison of two intravenous administration methods in a monophasic action potential modelBarthlow, H. / Duker, G. / Forsström, E. et al. | 2008
- 171
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Effects of d,l sotalol and verapamil on cardiovascular parameters in the conscious telemetered minipigPurbrick, S. / Openshaw, M. / Peake, G. et al. | 2008
- 171
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Assays for assessing cardiotoxicity in adult zebrafishPark, D. / Seng, W. L. / Li, C. et al. | 2008
- 171
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Effects of feeding on cardiovascular parameters measured in the conscious telemetered minipigOpenshaw, M. / Purbrick, S. / Peake, G. et al. | 2008
- 172
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Measurement of cardiovascular effects in minipigs using telemetrySkytte, C. / Makin, A. et al. | 2008
- 172
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Blood pressure and cardiac structure and function evaluation following treatment with sunitinib (SU11248, Sutent®)Blasi, E. R. / Steidl, J. / Patyna, S. et al. | 2008
- 172
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His bundle electrogram: A safety assessment of conductivity in anesthetized dogsRoche, B. M. / Kijtawornrat, A. / Lolly, J. L. et al. | 2008
- 173
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Effects of chronic morphine administration and acclimatisation to hypercapnia on hypercapnic response in the ratColes, D. / Scatchard, J. et al. | 2008
- 173
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Measurement of respiratory function by whole body plethysmography in unanesthetized and unrestrained monkeysSasaki, K. / Nakamura, Y. / Iizuka, H. et al. | 2008
- 173
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Application of the probabilistic method for QT rate-correction in telemetered beagles: Effects of moxifloxacinGreiter-Wilke, A. / Jenni, R. / Waiz, D. et al. | 2008
- 173
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Evaluation of respiratory function in conscious rats using whole body plethysmographyDeguchi, Y. / Tamai, A. / Anraku, R. et al. | 2008
- 174
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Respiratory assessment in tethered conscious beagle dogsAtterson, P. R. / Kearney, K. / Landis, K. et al. | 2008
- 174
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Intravenous bolus on rat respiratory study: What is the limit?Atterson, P. R. / Soloviev, M. / Kearney, K. et al. | 2008
- 174
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Refinement of the charcoal meal GI study: Reduction in the fasting period requiredPrior, H. / Ewart, L. / Fantham, E. et al. | 2008
- 174
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Detection of drug-induced emetic effects in miceAndo, K. / Takagi, K. et al. | 2008
- 175
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Gastrointestinal telemetry: A tool for studying the migrating motor complexes in the dogMilano, S. p. / Chalencon, E. / Lege, P. et al. | 2008
- 175
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Assessment of pharmacological effects on the gastrointestinal systemKirouac, A. / Rue, C. / Mason, S. et al. | 2008
- 175
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Combination of renal function investigation with plethysmography in rats: Refinement of the core batteryBetat, A. M. / Froget, G. / Lainee, P. et al. | 2008
- 175
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Safety pharmacology and biopharmaceutical developmentMaginn, M. et al. | 2008
- 176
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Exploratory INDs: Can they reduce the cost of pharmaceutical development?Kinter, L. B. / Kinter, E. / Bridges, J. et al. | 2008
- 176
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Repeated assessment of cardiovascular and respiratory functions using combined telemetry and plethysmography in the ratDelaunois, A. / Dedoncker, P. / Hanon, E. et al. | 2008
- 176
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Evaluation of effects on respiration in conscious cynomolgus monkeys (Macaca fascicularis) using whole body plethysmograSola-Puyravel, M. L. / Martel, E. / Champeroux, P. et al. | 2008
- 176
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Non cardiovascular safety pharmacology endpoints and their relationship to prevalent adverse events in first in human STScatchard, J. / Knight, T. et al. | 2008
- 177
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Zebrafish: The future of in vivo safety pharmacology screeningBerghmans, S. / Barros, T. / Golder, Z. et al. | 2008
- 177
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Development of a conscious rabbit telemetry model for chronic monitoring of blood pressure, ECG and temperatureD'Aubioul, J. / Van Eynde, E. / Cools, F. et al. | 2008
- 177
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Cardiovascular effects of d-sotalol and risperidone after oral administration in conscious guinea-pigs using telemetryLeoni, A. L. / Goubern, M. / Hervouet, S. et al. | 2008
- 177
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Assessment of cardiovascular parameters in teratology studiesHébert, N. / Pouliot, L. / Mason, S. et al. | 2008
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Editorial Board| 2008