A New Approach to Rapid Parallel Development of Four Neurokinin Antagonists. Part 2. Synthesis of ZD6021 Cyano Acid (Englisch)
- Neue Suche nach: Moseley, J. D.
- Neue Suche nach: Moss, W. O.
- Neue Suche nach: Welham, M. J.
- Neue Suche nach: Ancell, C. L.
- Neue Suche nach: Banister, J.
- Neue Suche nach: Bowden, S. A.
- Neue Suche nach: Norton, G.
- Neue Suche nach: Young, M. J.
- Neue Suche nach: Moseley, J. D.
- Neue Suche nach: Moss, W. O.
- Neue Suche nach: Welham, M. J.
- Neue Suche nach: Ancell, C. L.
- Neue Suche nach: Banister, J.
- Neue Suche nach: Bowden, S. A.
- Neue Suche nach: Norton, G.
- Neue Suche nach: Young, M. J.
In:
ORGANIC PROCESS RESEARCH AND DEVELOPMENT
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7
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58-66
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2003
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ISSN:
- Aufsatz (Zeitschrift) / Print
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Titel:A New Approach to Rapid Parallel Development of Four Neurokinin Antagonists. Part 2. Synthesis of ZD6021 Cyano Acid
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Beteiligte:Moseley, J. D. ( Autor:in ) / Moss, W. O. ( Autor:in ) / Welham, M. J. ( Autor:in ) / Ancell, C. L. ( Autor:in ) / Banister, J. ( Autor:in ) / Bowden, S. A. ( Autor:in ) / Norton, G. ( Autor:in ) / Young, M. J. ( Autor:in )
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Erschienen in:ORGANIC PROCESS RESEARCH AND DEVELOPMENT ; 7 ; 58-66
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Verlag:
- Neue Suche nach: AMERICAN CHEMICAL SOCIETY & ROYAL SOCIETY OF
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Erscheinungsdatum:01.01.2003
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Format / Umfang:9 pages
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ISSN:
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Medientyp:Aufsatz (Zeitschrift)
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Format:Print
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Sprache:Englisch
- Neue Suche nach: 547
- Weitere Informationen zu Dewey Decimal Classification
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Klassifikation:
DDC: 547 -
Datenquelle:
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Hazards XVI: Analysing the Past, Planning the Future 3-Day Symposium and Exhibition and 1-Day Workshop, November 5−8, 2001, at UMIST, Manchester, UK. Institution of Chemical Engineers: Rugby, UK. 2002. £100. 902 pp. ISBN 0-85295-441-7.| 2003
- 449
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Software for Process Research, Development, and Scale-upLaird, Trevor et al. | 2003
- 459
-
A Review of U.S. Patents in the Field of Organic Process Development Published during December 2002 through March 2003Turner, Keith et al. | 2003
- 471
-
Mixing and the Selectivity of Chemical ReactionsBourne, John R. et al. | 2003
- 509
-
Development of the Juliá−Colonna Asymmetric Epoxidation Reaction: Part 1. Preparation and Activation of the Polyleucine CatalystBaars, Sylvia / Drauz, Karl-Heinz / Krimmer, Hans-Peter / Roberts, Stanley M. / Sander, Jörg / Skidmore, John / Zanardi, Giampaolo et al. | 2003
- 509
-
Development of the Julia Colonna Asymmetric Epoxidation Reaction: Part 1. Preparation and Activation of the Polyleucine CatalystBaars, S. / Drauz, K.-H. / Krimmer, H.-P. / Roberts, S. M. / Sander, J. / Skidmore, J. / Zanardi, G. et al. | 2003
- 514
-
Chemical Development on the Chiral Auxiliary (S)-4-(Phenylmethyl)-2-oxazolidinone Utilizing Automated Synthesis and DoEVo, Lanchi / Ciula, James / Gooding, Owen W. et al. | 2003
- 521
-
Process Improvements for the Preparation of Kilo Quantities of a Series of Isoindoline CompoundsWatson, Timothy J. / Ayers, Timothy A. / Shah, Nik / Wenstrup, David / Webster, Mark / Freund, David / Horgan, Stephen / Carey, James P. et al. | 2003
- 533
-
The Synthesis of N-Aryl-5(S)-aminomethyl-2-oxazolidinone Antibacterials and Derivatives in One Step from Aryl CarbamatesPerrault, William R. / Pearlman, Bruce A. / Godrej, Delara B. / Jeganathan, Azhwarsamy / Yamagata, Koji / Chen, Jiong J. / Lu, Cuong V. / Herrinton, Paul M. / Gadwood, Robert C. / Chan, Lai et al. | 2003
- 547
-
A Practical Pilot-Scale Synthesis of 4-Vinyl-2,3-dihydrobenzofuran Using Imidate Ester Chemistry and Phase-Transfer CatalysisRao, Meena / Yang, Ming / Kuehner, Daniel / Grosso, John / Deshpande, Rajendra P. et al. | 2003
- 551
-
Conversion of Pollutants in Dilute Aqueous Waste Streams to Useful Products: a Potential Method Based on Phase-Transfer CatalysisBielski, Roman / Joyce, Peter J. et al. | 2003
- 553
-
Scale-Up of the Synthesis of a Pyrimidine Derivative Directly on Solid SupportMeisenbach, Mark / Allmendinger, Thomas / Mak, Ching-Pong et al. | 2003
- 559
-
Process Research of (R)-Cyclohexyl Lactic Acid and Related Building Blocks: A Comparative Study ‡Storz, Thomas / Dittmar, Peter / Fauquex, Pierre François / Marschal, Philippe / Lottenbach, Willy Urs / Steiner, Heinz et al. | 2003
- 571
-
Catalysts and Process for the Production of Benzyl ToluenesBarton, Benita / Hlohloza, Nkululeko S. / McInnes, Sonia M. / Zeelie, Bernard et al. | 2003
- 577
-
Continuous Process for the Production of Aromatic Hydrocarbons from n-Hexane and C5+ Natural Gas Liquid over Pd-Loaded ZSM-5 ZeoliteSuwanprasop, Somsaluay / Khamnuansiri, Pharkpoom / Nhujak, Thumnoon / Roengsumran, Sophon / Petsom, Amorn et al. | 2003
- 583
-
Effective Nonenzymatic Kinetic Resolution of (+/-)-trans-2-Arylcyclohexanols Using 3beta-Acetoxyetienic Acid, DCC, and DMAPMatsugi, M. / Hagimoto, Y. / Nojima, M. / Kita, Y. et al. | 2003
- 583
-
Effective Nonenzymatic Kinetic Resolution of (±)-trans-2-Arylcyclohexanols Using 3β-Acetoxyetienic Acid, DCC, and DMAPMatsugi, Masato / Hagimoto, Yuri / Nojima, Masatomo / Kita, Yasuyuki et al. | 2003
- 585
-
A Practical Synthesis of 3-n-Propylphenol, a Component of Tsetse Fly Attractant BlendsUjváry, István / Mikite, Gyula et al. | 2003
- 588
-
Novelties of Solid-Liquid Phase Transfer Catalysed Synthesis of alpha-Isopropyl-p-chlorophenyl Acetonitrile from p-Chlorophenyl AcetonitrileYadav, G. D. / Jadhav, Y. B. et al. | 2003
- 588
-
Novelties of Solid−Liquid Phase Transfer Catalysed Synthesis of α-Isopropyl-p-chlorophenyl Acetonitrile from p-Chlorophenyl AcetonitrileYadav, Ganapati D. / Jadhav, Yogeeta B. et al. | 2003
- 599
-
Thermochemical Scale-Up of a Mesylation ReactionBarozza, Alessandro / Velardi, Francesco / Fornaroli, Mirco et al. | 2003
- 609
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Encyclopaedia of Pharmaceutical Technology, 2nd edition Edited by J. Swarbrick and J. C. Boylan. 2002, Marcel Dekker: New York. 2002. 3 Volumes. 3032 + 64 pp. ISBN 0-8247-2822-X (Vol. 1), 0-8247-2823-8 (Vol. 2), 0-8247-2824-6 (Vol. 3), 0-8247-2825-4 (Prepack), 0-8247-2825-4 (Online).| 2003
- 609
-
On-line LC NMR and Related Techniques Edited by Klaus Albert. John Wiley & Sons: New York. 2002. 290 pp. £70.00/EUR115.50/$105. ISBN 0-471-49649-9.Marais, Fanie et al. | 2003
- 609
-
On-line LC NMR and Related TechniquesMarais, F. et al. | 2003
- 610
-
Developing an Industrial Chemical Process: An Integral Approach By J. Mizrahi. CRC Press: Boca Raton, FL. 2002. 229 pp. $140 (Paperback). ISBN 0-8493-1360-0.| 2003
- 611
-
Chemometrics: Data Analysis for the Laboratory and Chemical PlantRobinson, D. et al. | 2003
- 611
-
Chemometrics: Data Analysis for the Laboratory and Chemical Plant By Richard G. Brereton. John Wiley & Sons: Chichester. 2003. 489 pp. Paperback. £39.95/EUR 66.00. ISBN 0-471-48978-6.Robinson, Derek et al. | 2003
- 611
-
The Organic Chemistry of Enzyme-Catalysed Reactions By Richard E. Silverman. Academic Press: London. 2002. 717 pp. £59.95. ISBN 0-126-43731-9.| 2003
- 612
-
Solvent-Free Organic Synthesis By K. Tanaka. Wiley−VCH: Weinheim. 2003. 433 pp. £80. ISBN 3-527-30612-9.| 2003
- 613
-
The “Bookworm” Has Turned ...Laird, Trevor et al. | 2003
- 622
-
Concepts of Nature in Organic Synthesis: Cascade Catalysis and Multistep Conversions in ConcertBruggink, Alle / Schoevaart, Rob / Kieboom, Tom et al. | 2003
- 641
-
Highly Chemoselective Heterogeneous Pd-Catalyzed Biaryl Synthesis from Haloarenes: Reaction in an Oil-in-Water MicroemulsionMukhopadhyay, Sudip / Yaghmur, Anan / Baidossi, Mubeen / Kundu, Buddhadeb / Sasson, Yoel et al. | 2003
- 644
-
A Scalable Synthesis of (R)-3,5-Dihydro-4H-dinaphth[2,1-c:1‘2‘-e]azepineIkunaka, Masaya / Maruoka, Keiji / Okuda, Yoshiaki / Ooi, Takashi et al. | 2003
- 649
-
Practical Large-Scale Synthesis of the 2-Aminomethylpyrrolidin-4-ylthio-Containing Side Chain of the Novel Carbapenem Antibiotic DoripenemNishino, Yutaka / Komurasaki, Tadafumi / Yuasa, Tetsuya / Kakinuma, Makoto / Izumi, Kenji / Kobayashi, Makoto / Fujiie, Shinichiro / Gotoh, Teruhiro / Masui, Yoshiyuki / Hajima, Makoto et al. | 2003
- 655
-
The Development of a Manufacturing Route for the GPIIb/IIIa Receptor Antagonist SB-214857-A. Part 1: Synthesis of the Key Intermediate 2,3,4,5-Tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic Acid Methyl Ester, SB-235349Andrews, Ian P. / Atkins, Richard J. / Breen, Gary F. / Carey, John S. / Forth, Michael A. / Morgan, David O. / Shamji, Amin / Share, Andrew C. / Smith, Stephen A. C. / Walsgrove, Timothy C. et al. | 2003
- 663
-
The Development of a Manufacturing Route for the GPIIb/IIIa Receptor Antagonist SB-214857-A. Part 2: Conversion of the Key Intermediate SB-235349 to SB-214857-AAtkins, Richard J. / Banks, Adam / Bellingham, Richard K. / Breen, Gary F. / Carey, John S. / Etridge, Stephen K. / Hayes, Jerome F. / Hussain, Nigel / Morgan, David O. / Oxley, Paul et al. | 2003
- 676
-
Cross-Coupling Methods for the Large-Scale Preparation of an Imidazole−Thienopyridine: Synthesis of [2-(3-Methyl-3H-imidazol-4-yl)- thieno[3,2-b]pyridin-7-yl]-(2-methyl-1H-indol-5-yl)-amineRagan, J. A. / Raggon, J. W. / Hill, P. D. / Jones, B. P. / McDermott, R. E. / Munchhof, M. J. / Marx, M. A. / Casavant, J. M. / Cooper, B. A. / Doty, J. L. et al. | 2003
- 684
-
Reactions in Closed Batch Reactors, Operational and Safety Issues: A Model To Predict How Degree of Filling and Rate of Heating Affect Reaction Times and Buildup of Internal PressureGalliani, Guido / Orlandi, Marco / Rindone, Bruno et al. | 2003
- 692
-
An Efficient One-Pot Process for 10-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one, an Intermediate to SCH 66336Fu, Xiaoyong / McAllister, Timothy L. / Shi, Xiongwei / Thiruvengadam, T. K. / Tann, Chou-Hong / Lee, Junning et al. | 2003
- 696
-
An Improved Method for the Palladium Cross-Coupling Reaction of Oxazol-2-ylzinc Derivatives with Aryl BromidesReeder, Michael R. / Gleaves, Harold E. / Hoover, Sheree A. / Imbordino, Rick J. / Pangborn, Jeffrey J. et al. | 2003
- 700
-
The Process Development of a Novel Aldose Reductase Inhibitor, FK366. Part 1. Improvement of Discovery Process and New Syntheses of 1-Substituted QuinazolinedionesGoto, Shunsuke / Tsuboi, Hiroyuki / Kanoda, Masami / Mukai, Koji / Kagara, Kooji et al. | 2003
- 707
-
Scalability of Microwave-Assisted Organic Synthesis. From Single-Mode to Multimode Parallel Batch ReactorsStadler, Alexander / Yousefi, Behrooz H. / Dallinger, Doris / Walla, Peter / Van der Eycken, Erik / Kaval, Nadya / Kappe, C. Oliver et al. | 2003
- 717
-
Temperature Selective Diastereo-Recognition (TSD): Enantiomeric Ibuprofen via Environmentally Benign Selective CrystallizationBhattacharya, Apurba / Murphy, David et al. | 2003
- 723
-
Design of New Reaction Conditions for the Sugasawa Reaction Based on Mechanistic Insights ‡Prasad, Kapa / Lee, George T. / Chaudhary, Apurva / Girgis, Michael J. / Streemke, James W. / Repič, Oljan et al. | 2003
- 733
-
A Practical Synthesis of 6-[2-(2,5-Dimethoxyphenyl)ethyl]-4-ethylquinazoline and the Art of Removing Palladium from the Products of Pd-Catalyzed ReactionsKönigsberger, Kurt / Chen, Guang-Pei / Wu, Raeann R. / Girgis, Michael J. / Prasad, Kapa / Repič, Oljan / Blacklock, Thomas J. et al. | 2003
- 743
-
Kinetically Controlled Diastereoselective Synthesis of CPS124, a Carnitine MonothiophosphatePrasad, Kapa / Xu, David D. / Tempkin, Orin / Villhauer, Edwin B. / Repič, Oljan et al. | 2003
- 750
-
Isolation and Identification of the Major Extractable Impurity from Dowex 1×2 ResinTou, Jacob S. / Kostelc, James G. / Schlittler, Michael R. / Violand, Bernard N. et al. | 2003
- 750
-
Isolation and Identification of the Major Extractable Impurity from Dowex 1x2 ResinTou, J.S. et al. | 2003
- 754
-
A Novel Method for the Direct Sulfonation of CH4 with SO3 in the Presence of KO2 and a PromoterMukhopadhyay, Sudip / Bell, Alexis T. et al. | 2003
- 758
-
Identification and Control of a Process-Related Impurity in the Chlorination of 3-Hydroxy-3-carbacephemKumar, Yatendra / Tewari, Neera / Nizar, Hashim / Rai, Bishwa Prakash / Singh, Shailendra Kumar et al. | 2003
- 762
-
Continuous-Flow Generation of Anhydrous Diazonium Species: Monolithic Microfluidic Reactors for the Chemistry of Unstable IntermediatesFortt, Robin / Wootton, Robert C. R. / de Mello, Andrew J. et al. | 2003
- 769
-
Kinetics of Liquid-Phase Catalytic Hydrogenation of Benzophenone to BenzhydrolBawane, Sunil P. / Sawant, Sudhirprakash B. et al. | 2003
- 775
-
Easier-To-Read Reaction SchemesLaird, Trevor et al. | 2003
- 784
-
A Review of U.S. Patents in the Field of Organic Process Development Published during April to July 2003Turner, Keith et al. | 2003
- 794
-
A Convenient Nitroxyl Radical Catalyst for the Selective Oxidation of Primary and Secondary Alcohols to Aldehydes and Ketones by O2 and H2O2 under Mild ConditionsMinisci, Francesco / Recupero, Francesco / Rodinò, Marianna / Sala, Massimiliano / Schneider, Armin et al. | 2003
- 799
-
A Scalable Synthesis of Meso-Substituted DipyrromethanesLaha, Joydev K. / Dhanalekshmi, Savithri / Taniguchi, Masahiko / Ambroise, Arounaguiry / Lindsey, Jonathan S. et al. | 2003
- 813
-
Phase-Transfer Catalytic Reaction of 4,4‘-Bis(Chloromethyl)-1,1‘-biphenyl and 1-Butanol in a Two-Phase MediumWang, Maw-Ling / Lee, Ze-Fe et al. | 2003
- 821
-
Development of Jacobsen Asymmetric Epoxidation and Sharpless Asymmetric Dihydroxylation Methods for the Large-Scale Preparation of a Chiral Dihydrobenzofuran EpoxidePrasad, J. Siva / Vu, Truc / Totleben, Michael J. / Crispino, Gerard A. / Kacsur, David J. / Swaminathan, Shankar / Thornton, John E. / Fritz, Alan / Singh, Ambarish K. et al. | 2003
- 828
-
Enzymatic Hydrocyanation of a Sterically Hindered Aldehyde. Optimization of a Chemoenzymatic Procedure for (R)-2-Chloromandelic Acidvan Langen, Luuk M. / van Rantwijk, Fred / Sheldon, Roger A. et al. | 2003
- 832
-
Synthesis of High-Quality Antisense Drugs. Addition of Acrylonitrile to Phosphorothioate Oligonucleotides: Adduct Characterization and AvoidanceCapaldi, Daniel C. / Gaus, Hans / Krotz, Achim H. / Arnold, Jim / Carty, Ricaldo L. / Moore, Max N. / Scozzari, Anthony N. / Lowery, Kirsten / Cole, Douglas L. / Ravikumar, Vasulinga T. et al. | 2003
- 839
-
The Chemical Development of LB71350Lee, Kyu Woong / Hwang, Sang Yeul / Kim, Chung Ryeol / Nam, Do Hyun / Chang, Jay Hyok / Choi, Sang Chul / Choi, Bo Seung / Choi, Hyeong-wook / Lee, Ki Kon / So, Byungran et al. | 2003
- 846
-
Practical Large-Scale Synthesis of Doripenem: A Novel 1beta-Methylcarbapenem AntibioticNishino, Y. / Kobayashi, M. / Shinno, T. / Izumi, K. / Yonezawa, H. / Masui, Y. / Takahira, M. et al. | 2003
- 846
-
Practical Large-Scale Synthesis of Doripenem: A Novel 1b-Methylcarbapenem AntibioticNishino, Y. et al. | 2003
- 846
-
Practical Large-Scale Synthesis of Doripenem: A Novel 1β-Methylcarbapenem AntibioticNishino, Yutaka / Kobayashi, Makoto / Shinno, Taneyoshi / Izumi, Kenji / Yonezawa, Hiroshi / Masui, Yoshiyuki / Takahira, Masayuki et al. | 2003
- 851
-
An Efficient and Cost-Effective Synthesis of PagocloneStuk, Timothy L. / Assink, Bryce K. / Bates,, Ronald C. / Erdman, David T. / Fedij, Victor / Jennings, Sandra M. / Lassig, Jennifer A. / Smith, Randy J. / Smith, Traci L. et al. | 2003
- 856
-
An Expedient Synthesis of LAF389, a Bengamide B AnalogueXu, David D. / Waykole, Liladhar / Calienni, John V. / Ciszewski, Lech / Lee, George T. / Liu, Wenming / Szewczyk, Joanna / Vargas, Kevin / Prasad, Kapa / Repič, Oljan et al. | 2003
- 866
-
A Practical Synthesis of the Platelet Fibrinogen Antagonist, ElarofibanCohen, Judith H. / Bos, Mary Ellen / Cesco-Cancian, Sergio / Harris, Bruce D. / Hortenstine, John T. / Justus, Michael / Maryanoff, Cynthia A. / Mills, John / Muller, Stefan / Roessler, Armin et al. | 2003
- 873
-
Synthesis and Purification of 6-Ethoxy-4-oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic Acid BenzylamideBeaudin, Justin / Bourassa, Dennis E. / Bowles, Paul / Castaldi, Michael J. / Clay, Ronald / Couturier, Michel A. / Karrick, Gregory / Makowski, Teresa W. / McDermott, Ruth E. / Meltz, Clifford N. et al. | 2003
- 879
-
Inhibition of the Cobalt Acetate/Bromide-Catalyzed Hydrogen Peroxide Oxidation of 4-tert-ButyltolueneAmin, Ahmed A. / Beattie, James K. et al. | 2003
- 883
-
Practical Synthesis of N-{4-[(2-Methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin- 6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide Monohydrochloride: an Arginine Vasopressin AntagonistTsunoda, Takashi / Yamazaki, Atsuki / Iwamoto, Hidenori / Sakamoto, Shuichi et al. | 2003
- 888
-
CO2 Offgas as a Mechanistic Probe and Scale-up Tool in N-Acylations Using Mixed Anhydrides from Amino Acids and Isobutyl ChloroformateChaudhary, Apurva / Girgis, Michael J. / Prashad, Mahavir / Hu, Bin / Har, Denis / Repič, Oljan / Blacklock, Thomas J. et al. | 2003
- 896
-
Synthesis and Characterisation of Impurities of Manufacture in Support of Certificate of the European Pharmacopoeia Applications Part 1 (Clobetasone Butyrate)McGhie, Stephen / Sewell, Alan / Devlin, John / Wilson, Mark J. / Newton, Lee / McLaren, Kirsty / Thomson, Maranda / Cobb, Steven / Ferguson, Jacqueline / Prudhoe, Kevin et al. | 2003
- 904
-
A New Practical Route for the Manufacture of (4aR,10aR)-9-Methoxy-1-methyl-6-trimethylsilanyl- 1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolineBänziger, Markus / Küsters, Ernst / Vecchia, Luigi La / Marterer, Wolfgang / Nozulak, J. et al. | 2003
- 913
-
Process Development and Pilot Plant Scale Synthesis of Spiro[3.5]nonane-6,8-dioneLehmann, Thomas E. / Kuhn, Oliver / Krüger, Jochen et al. | 2003
- 917
-
Efficient Synthesis of Antisense Phosphorothioate Oligonucleotides: Evaluation of Dichloroacetic Acid at Higher Concentration to Reduce Cycle TimeCheruvallath, Zacharia S. / Carty, Recaldo L. / Andrade, Mark / Moore, Max N. / Song, Quinlai / Rentel, Claus / Cole, Douglas L. / Ravikumar, Vasulinga T. et al. | 2003
- 921
-
A Convenient Synthesis of High-Purity 1-Chloro-2,6-difluorobenzeneMoore, Robert M. et al. | 2003
- 925
-
Hydrolysis of Cyclic Phosphites/Phosphoramidites and Its Inhibition-Reversible Cyclization of Acyclic Phosphonate Salts to Cyclic PhosphitesSatish Kumar, N. / Kumaraswamy, Sudha / Said, Musa A. / Kumara Swamy, K. C. et al. | 2003
- 929
-
Chemoselective Removal of Dimeric 1,3-Diol Impurities Generated from Methyl Grignard Addition onto EstersTucker, John L. / Couturier, Michel / Leeman, Kyle R. / Hinderaker, Matthew P. / Andresen, Brian M. et al. | 2003
- 933
-
Process for Developing 3b-(4-(S)-Arylacetylamino-4b-(2-(2-furyl)ethyl)azetidin-2-one: A Carbacephem Key IntermediateKumar, Y. et al. | 2003
- 933
-
Process for Developing 3beta-[4-(S)-Arylacetylamino-4beta-(2-(2-furyl)-ethyl]azetidin-2-o ne: A Carbacephem Key IntermediateKumar, Y. / Tewari, N. / Nizar, H. / Rai, B. P. / Singh, S. K. et al. | 2003
- 933
-
Process for Developing 3β-[4-(S)-Arylacetylamino-4β-(2-(2-furyl)ethyl]azetidin-2-one: A Carbacephem Key IntermediateKumar, Yatendra / Tewari, Neera / Nizar, Hashim / Rai, Bishwa Prakash / Singh, Shailendra Kumar et al. | 2003
- 936
-
A Kinetic Study of 2-Ethyl-1-hexanol Oxidation by Dichromate Using Clay-Supported 1-Butyl 4-aza-1-azonia Bicyclo[2.2.2]octane Chloride as the Phase-Transfer CatalystGhiaci, M. / Kalbasi, R. J. / Sedaghat, M. E. et al. | 2003
- 939
-
Synthesis of T2288: From Bench Synthesis to Pilot ProductionGuillaume, Michel / Cuypers, Jef / Vervest, Ivan / De Smaele, Dirk / Leurs, Stef et al. | 2003
- 942
-
Modelling the Kinetics of a Reaction Involving a Sodium Salt of 1,2,4-Triazole and a Complex Substituted Aliphatic HalideGrénman, H. / Salmi, T. / Mäki-Arvela, P. / Wärnå, J. / Eränen, K. / Tirronen, E. / Pehkonen, A. et al. | 2003
- 951
-
Pilot-Scale Lipase-Catalyzed Regioselective Acylation of Ribavirin in Anhydrous Media in the Synthesis of a Novel Prodrug IntermediateTamarez, Maria / Morgan, Brian / Wong, George S. K. / Tong, Weidong / Bennett, Frank / Lovey, Raymond / McCormick, Jinping L. / Zaks, Aleksey et al. | 2003
- 954
-
A Comparison between Kinetic Parameters from the Synthesis of Tris(p-nitrophenyl)phosphite and Tris(p-nitrophenyl)phosphate Using Reaction CalorimetrySeiceira, Rafael C. / Machado e Silva, Carlos F. P. / Estevão, Luciana R. M. / Cajaiba da Silva, João F. et al. | 2003
- 957
-
SPECIAL FEATURE SECTION: POLYMORPHISM AND CRYSTALLIZATIONLaird, Trevor et al. | 2003
- 958
-
An Etoricoxib Phase Diagram: Hemihydrate and AnhydrateCrocker, Louis S. / Ge, Zhihong / Abrahim, Ahmed / Hartman, Robert / Xu, Jing et al. | 2003
- 962
-
Polymorphic Study of l-Arginine Salt of Ragaglitazar (DRF-2725) †Raju, S. / Kumar, P. Rajender / Vyas, K. / Rao, D. Srinivas / Sarma, M. R. / Reddy, S. Vishnuvardhan / Nirmala, M. / Reddy, G. Om et al. | 2003
- 970
-
Structural Characterization of Industrially Relevant Polymorphic Materials from Powder Diffraction DataHarris, Kenneth D. M. / Cheung, Eugene Y. et al. | 2003
- 977
-
In Situ Monitoring of Polymorphic TransitionsO'Sullivan, Brian / Barrett, Paul / Hsiao, Gregor / Carr, Alun / Glennon, Brian et al. | 2003
- 983
-
Phase Transitions in Supersaturated Drug SolutionVeesler, Stéphane / Lafferrère, Laurent / Garcia, Eric / Hoff, Christian et al. | 2003
- 990
-
Salt Selection and Simultaneous Polymorphism Assessment via High-Throughput Crystallization: The Case of SertralineRemenar, Julius F. / MacPhee, J. Michael / Larson, Bridget K. / Tyagi, Viraj A. / Ho, Jason H. / McIlroy, David A. / Hickey, Magali B. / Shaw, Paul B. / Almarsson, Örn et al. | 2003
- 997
-
Crystallization Process Development of an Active Pharmaceutical Ingredient and Particle Engineering via the Use of Ultrasonics and Temperature CyclingKim, Soojin / Wei, Chenkou / Kiang, San et al. | 2003
- 1002
-
Particle Engineering Using Power UltrasoundDennehy, R. D. et al. | 2003
- 1002
-
Particle Engineering Using Power Ultrasound1Dennehy, Robert Daniel et al. | 2003
- 1007
-
Combined Effect of Polymorphism and Process on Preferential Crystallization: Example with (±)-5(4‘-Methylphenyl)-5-methylhydantoinCourvoisier, L. / Mignot, L. / Petit, M. N. / Coquerel, G. et al. | 2003
- 1007
-
Combined Effect of Polymorphism and Process on Preferential Crystallization: Example with ((plus-minus))-5(4'-Methylphenyl)-5-methylhydantoinCourvoisier, L. et al. | 2003
- 1017
-
Structural and Thermodynamic Explanations of Ostwald's RuleThrelfall, Terry et al. | 2003