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A study has been made of the liquid thermal diffusion method of separating uranium isotopes. In the course of the research 29 diffusion columns have been built and tested. At present a 14 unit pilot plant is undergoing tests. Separations between end fractions of 45.5% have been obtained by the use of two 48 ft columns connected in series. This series pair is capable of producing two fractions of UF6, 1 kg of each, possessing an isotope separation factor of 1.2. Work to date shows the apparatus to be unusually dependable and capable of long time trouble free operation. Separation of uranium isotopes on a large scale by the method is a practical possibility. The initial cost for a 1 kg 90% U235 per day plant is estimated. The various other methods of isotope separation are discussed. Liquid thermal diffusion compares favorably with any of them. An alternative to the 1 kg 90% U235 plant is presented. This involves the preparation of large amounts of 1.6% U235 and its use by the Chicago group. Potentialities for improvement of separation factor and relaxation time have not been exhausted. Further research work is desirable before the design of a large plant is attempted.