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The Tele-Medicine sub-services backed up by a novel, open- architecture Tele-Working platform, are evaluated. This multimedia platform, developed over the Hellenic Integrated Services Digital Network (ISDN), is based on user terminals (personal computers), networking apparatus, and a central database. The developed product equips the Hellenic PTT Organization (OTE) with a ready-to-be applied novel service that would supply future subscribers (MDs) the means to remotely collaborate in real time, exchange data on- and off-line, enhance their diagnoses, electronically fix, accept, or modify patient visits, build' virtual rooms to meet, etc. The platform, especially focused to implement a Tele-Medicine system, was tested for a period of over nine (9) months through a network of twenty-two (22) nodes situated in remote counties of Hellas.