Bitte wählen Sie ihr Lieferland und ihre Kundengruppe
This study investigated the acute oral toxicity of 2,6-di-t-butyl-4- nitrophenol (DBNP) in male Sprague-Dawley rats. DBNP is formed in U.S. submarines when lube oil containing the antioxidant additive 2,6-di-t- butylphenol (DBP) is nitrated after passing through an electrostatic precipitator. DBNP has triggered human health concerns due to its adherence to painted surfaces causing a noticeable yellowing. Male Sprague-Dawley rats were dosed with DBNP in corn oil. Survivors at each dose level were 5/5 at 62.5 mg/ kg, 4/5 at 78 mg/kg, 2/5 at 98 mg/kg, and 015 at 250 mg/kg. The LD50 of DBNP in corn oil is 93 mg/kg. The No Observable Effect Level for DBNP is less than 62.5 mg/kg. Hyperthermia and severe rigor were found in treated animals.