Zellzyklusverzoegerungen synchroner Zellpopulationen nach Schwerionenstrahlung. (Cell cycle delays in synchronized cell populations following irradiation with heavy ions)
(Englisch)
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Mammalian cells subjected to irradiation with heavy ions were investigated for cell cycle delays. The ions used for this purpose included Ne ions in the LET range of 400 keV/(mu)m just as well as uranium ions of 16225 keV/(mu)m. The qualitative changes in cell cycle progression seen after irradiation with Ne ions (400 keV/(mu)m) were similar to those observed in connection with X-rays. Following irradiation with extremely heavy ions (lead, uranium) the majority of cells were even at 45 hours still found to be in the S phase or G(sub 2)M phase of the first cycle. The delay cross section '(sigma)-delay' was introduced as a quantity that would permit quantitative comparisons to be carried out between the changes in cell progression and other effects of radiation. In order to evaluate the influence of the number of hits on the radiation effect observed, the size of the cell nucleus was precisely determined with reference to the cycle phase and local cell density. A model to simulate those delay effects was designed in such a way that account is taken of this probability of hit and that the results can be extrapolated from the delay effects after X-irradiation. On the basis of the various probabilities of hit for cells at different cycle stages a model was developed to ascertain the intensified effect following fractionated irradiation with heavy ions. (orig./MG). (ERA citation 18:021625)
Zellzyklusverzoegerungen synchroner Zellpopulationen nach Schwerionenstrahlung. (Cell cycle delays in synchronized cell populations following irradiation with heavy ions)