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This citation summarizes a one-page announcement of technology available for utilization. Changes in the number and structure of chromosomes may be one of the earliest detectable events in the spontaneous progression of cells toward the tumorigenic state, according to researchers at the Los Alamos National Laboratory in New Mexico. Studies indicate that the chromosomal change precedes the onset of tumorigenesis and the appearance of properties associated with transformed cells. Investigators at the laboratory say that the earliest stage of the spontaneous cancer process may result from a doubling in the number of chromosomes. Because cells with extra chromosomes are unstable, these cells retain only one or two of the extra chromosomes in addition to the normal number. Dr. L. Scott Cram, staff scientist and director of the National Flow Cytometry Resource, Dr. Paul Kraemer and their associates are using cultured Chinese hamster cells to characterize the initial events of tumor formation. ...FOR ADDITIONAL INFORMATION: Contact: National Institutes of Health, Research Resources Information Center, 1601 Research Blvd., Rockville, MD 20850; (301) 984-2870.