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This report presents the results of preliminary design analyses of repositories in crystalline rock using three different waste emplacement concepts. Design parameter variations and potential site-to-site variations in rock properties and conditions are investigated with respect to repository performance. The objective is (1) to define the rock properties and initial conditions whose site-to-site variations have a significant effect on repository performance, and (2) to evaluate the effect of repository system design parameters on repository performance. Within the range of anticipated variations in rock properties and conditions, repository interim performance constraints can generally be satisfied by appropriate design. However, not all constraints, as presently established, may be satisfied if (1) the rock properties or initial conditions at a specific site are at the extreme end of the ranges used in the analyses, and (2) design parameters are maintained within the ranges used in this analysis. When all of the interim performance constraints are considered, none of the waste emplacement concepts exhibits an advantage over another with respect to maximization of allowable gross thermal loading. (ERA citation 10:026847)