Bitte wählen Sie ihr Lieferland und ihre Kundengruppe
Changes in production of lymph during enterotoxemia induced by administration of staphylococcic enterotoxin B (SEB) were determined in rhesus monkeys (Macaca mulatta). Radioiodinated serum albumin (RISA) kinetics, thoracic duct lymph flow, and central arterial pressure were measured, and vascular permeability was derived by calculation. Control monkeys studied with an identical experimental method had relatively stable measurements for many hours, but monkeys with enterotoxemia induced by an intravenous (I.V.) injection of SEB had hypotension, increased thoracic duct lymph flow, and altered RISA kinetics indicative of an increased vascular permeability. These data indicated that toxic effects on vascular endothelium were initiated by SEB. (Author)