NTP Technical Report on the Toxicology and Carcinogenesis Studies of 3,3',4,4'-Tetrachloroazobenzene (TCAB) (CAS NO. 14047-09-7) in Harland Sprague-Dawley Rats and B6C3F1 Mice (Gavage Studies)
(Englisch)
2010
Report
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3,3',4,4'-Tetrachloroazobenzene (TCAB) is not commercially manufactured but is formed as an unwanted by-product in the manufacture of 3,4-dichloroaniline and its herbicidal derivatives Propanil(Trade Name),Linuron(Trade Name), and Diuron(Trade Name). It occurs from the degradation of chloroanilide herbicides (acylanilides, phenylcarbamates,and phenylureas) in soil by peroxide-producing microorganisms and is formed by the photolysis and biolysis of 3,4-dichloroaniline. Humans maybe exposed to TCAB during the manufacture as well as the application of herbicides containing TCAB as a contaminant. TCAB was nominated by the United States Environmental Protection Agency for toxicity and carcinogenicity testing based on its structural and biological similarity to 2,3,7,8-tetrachlor odibenzo-p-dioxin (TCDD) and the potential for human exposure from the consumption of crops contaminated with 3,4-dichloroaniline-derived herbicides. Male and female Harlan Sprague-Dawley rats and B6C3F1 mice were administered TCAB (at least 97.8% pure) in corn oil:acetone (99:1) by gavage for 3 months (rats only) or 2 years.
NTP Technical Report on the Toxicology and Carcinogenesis Studies of 3,3',4,4'-Tetrachloroazobenzene (TCAB) (CAS NO. 14047-09-7) in Harland Sprague-Dawley Rats and B6C3F1 Mice (Gavage Studies)