Increasing Nigral Tyrosine Hydroxylase Expression as a Mechanism of Exercise-Mediated Recovery: Evaluation in Toxin and Rat Parkinson's Disease Genetic Models
(Englisch)
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The health benefits of regular exercise are documented in hundreds of studies. However, only recently have the potential benefits of exercise to alleviate symptoms of neurologically-based diseases come to light. In Parkinsons disease (PD), exercise can alleviate some of the locomotor impairments. However, not all PD patients are able to exercise due to other contraindications in health or lifestyle constraints which prevent them from exercising. For these reasons, it is vital to determine the neurobiological basis of how exercise improves locomotor function. Identification of a neurobiological mechanism that drives motor improvement following exercise can yield a target for a pharmacological or genetic approaches to improve motor function in PD patients unable to exercise. Using an established rodent model of PD, this proposal tests our hypothesis that exercise-related improvement in motor function is associated with increased expression of the dopamine-regulating protein tyrosine hydroxylase in the substantia nigra. Evidence to support this relationship will guide future research for genetic and pharmacological strategies to increase expression of tyrosine hydroxylase (TH) in the substantia nigra, which is severely decreased in PD, but still potentially salvageable in comparison to much greater TH loss in striatum.
Increasing Nigral Tyrosine Hydroxylase Expression as a Mechanism of Exercise-Mediated Recovery: Evaluation in Toxin and Rat Parkinson's Disease Genetic Models