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The purpose of this study was to evaluate six standards being considered as potential initial standards for e-prescribing under Medicare Part D. The standards being considered are for drug formulary & benefit information, patients medication histories, the fill status of individual prescriptions, electronic prior authorization (ePA) requests, drug identifiers, and the Sig portion of prescriptions. The study was conducted among participants in the E-Prescribe program of Horizon Blue Cross Blue Shield of New Jersey. Each standard was evaluated through one or more of the following methods: workflow modeling, an expert panel process, physician and pharmacy site visits, a survey of e-prescribing participants and non-participants, analyses of prescription claims before and after e-prescribing activation, the creation and deployment of a working prototype system for electronic PA, prescriber focus groups, and tests of the standards capacity to represent a sample of actual prescriptions.