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Introduction: Guided tissue regeneration with demineralized freeze-dried bone allograft (DFDBA) and a barrier membrane predictably improves clinical parameters in intrabony defects. Accell Connexus(AC) is a grafting material composed of DFDBA blended with DFDBA processed for rapid growth factor release and a polymer putty. Purpose: This randomized, double-blinded study compared AC to DFDBA for periodontal regeneration in intrabony defects when used with a resorbable collagen membrane. Methods: 25 subjects were enrolled and randomly assigned to receive AC or DFDBA for treatment of an intrabony defect. Probing depth and clinical attachment level changes were measured using custom stents at baseline, 6 and 12 months. Results: 20 subjects completed the study. Both AC (n=10) and DFDBA (n=10) groups improved significantly after treatment with no between-group differences for probing depth reduction or clinical attachment gain. Conclusion: Periodontal regeneration with Accell Connexus is comparable to DFDBA for probing depth reduction and clinical attachment level gain.