(57)Co-Bleomycin and I-Bleomycin in Ehrlich's Carcinoma Model of the Mouse. Tumour Concentration, Organ Distribution, Whole Body Retention and Stability
(Englisch)
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The tumour concentration, distribution of activity and whole body retention of bleomycin labeled with iodine-125 or iodine-131 was contrasted with that of (57)Co-bleomycin following administration to mice showing tumors. Additional investigations were carried out to determine the stability of iodinated bleomyin in vivo and in vitro. As regards the behavior of I-bleomycin in mice showing solid carcinomas according to Ehrlich it was established that its absolute tumor concentration was lower and its relative tumor concentration just slightly less pronounced than that of (57)Co-bleomycin during the period between 2 and 48 hours following administration. Investigations into whole body retention showed the elimination of activity to be more rapid for (131)I-bleomycin as compared to (57)Co-bleomycin. Bleomycin that was radioiodinated according to the iodine monochloride method proved to be more stable in vivo than bleomycin labeled with (57)Co. Further studies, in particular clinical trials, will have to be carried out before definite conclusions can be drawn as to the diagnostic value of radioiodinated bleomycin in tumor localisation. (ERA citation 14:011906)
(57)Co-Bleomycin and I-Bleomycin in Ehrlich's Carcinoma Model of the Mouse. Tumour Concentration, Organ Distribution, Whole Body Retention and Stability