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Motivated by the recent development in fabricating graphene/carbon nanotube-based surface compliant loud speakers, the effectiveness of thermoacoustic actuators that locally introduce high-intensity acoustic waves for active flow control is examined by performing high-fidelity large eddy simulation for compressible flow over a wall-mounted hump at a Reynolds number of 0:5 x 1000000 and Mach number of 0.25. Based on performance characteristics of the grephene-based thermoacoustic actuators, high-frequency actuation around Helmholtz number of 3.0 is considered. We observe that the actuation is able to introduce small-scale perturbations to the shear layer in the separated ow and attenuate the formation of large scale spanwise vortices. This ow control technique elongates the recirculation zone and shifts the low-pressure region downstream of the hump. As a consequence, the drag on the hump is reduced by approximately 4.31% and 6.33% for two and three-dimensional simulation, respectively.