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An immunoaffinity method according an embodiment of the present invention is described for selectably removing highly abundant proteins (HAP) from a sample which contains a mixture of HAP and lower abundance proteins (LAP). One method includes providing a sample having a concentration of original HAP and LAP therein and producing antibodies to the sample. The sample is subjected to a subtractive immunoaffinity chromatography process which employs the antibodies produced. A purified sample is collected which has been subjected to the subtractive immunoaffinity chromatography process. The purified sample is characterized in that the concentration of original HAP has been selectably reduced as compared to the concentration of original LAP. The purified sample now includes a concentration of new HAP and LAP. Also described are antibody compositions, methods for purification of a specimen for analysis, and systems for carrying out the described methods.