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This paper will review the development and application of the CDISC aerodynamic design method that began in the early 1980s and continues in active use today. The method uses an iterative, knowledge-based approach that has been coupled with numerous flow solvers utilizing a variety of grid types and levels of flow physics. It has been applied to configurations varying in complexity from 2-D airfoils to full 3-D aircraft at flow conditions ranging from low-speed, high-lift to supersonic cruise. The knowledge-based approach provides a very rapid design process, with designs typically completed in approximately 1-2x the time required for an initial converged analysis of the baseline. The evolution of the method as it tracked the expansive growth of grid and flow solver technology, along with some major applications over 5 decades, are given, followed by a description of the philosophy and process used in design. Finally, an example of its use in a preliminary design environment is given.