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Orphan nuclear receptor COUP-TEll plays important roles in controlling diverse aspects of cell growth, development, differentiation and homeostasis. During the development, its expression is spatially and temporally restricted within mesenchymal cells of many organs (including developing prostate glands) that require interactions between the mesenchymal and epithelial compartments for proper development. The timing and expression pattern of COUP-TEll in prostate are closely correlated with the development and differentiation of the prostate glands, suggesting that COUP-TEll is an important modulator for mesenchymal- epithelial interactions required for the normal prostate development and tumorgenesis of prostate cancer. To study COUP- TEll's function during the development of prostate gland and the carcinogenesis of prostate cancer, we have successfully generated adenoviral vectors that effectively express sense and antisense COUP-TEll mPNA. More effort is being devoted to analyze the effect of COUP-TEll over- or under-expression on the ability of mesenchyme to induce epithelial differentiation, and the ability of tumorigenesis of prostate cancer cell lines. In addition, we established rUGM cell lines which over- and under-express COUP-TEll. The effect of changing the level of COUP-TEll expression in rUGM cells on the modulation of tumor growth induced by epithelial cells in asthymic nude mice will be studied. 14. SUBJECT TERMS Is. NUMBER OF PAGES Prostate Cancer 17.