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This report is based on research conducted by the Agency for Healthcare Research and Quality (AHRQ) Evidence-based Practice Centers 2014 Methods Workgroup 3. The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services. The information in this report is intended to help health care decisionmakerspatients and clinicians, health system leaders, and policymakers, among othersmake well-informed decisions and thereby improve the quality of health care services. This report is not intended to be a substitute for the application of clinical judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical reference and in conjunction with all other pertinent information (i.e., in the context of available resources and circumstances presented by individual patients). AHRQ or U.S. Department of Health and Human Services endorsement of any derivative products that may be developed from this report, such as clinical practice guidelines, other quality enhancement tools, or reimbursement or coverage policies may not be stated or implied . This document is in the public domain and may be used and reprinted without permission except those copyrighted materials that are clearly noted in the document. Further reproduction of those copyrighted materials is prohibited without the specific permission of copyright holders. This research was funded through contracts from the Agency for Healthcare Research and Quality to the following Evidence-based Practice Centers: The Johns Hopkins University (290-2012-00007-I), Pacific Northwest (290-2012-00014-I), University of Alberta (290-2012-00013-I), University of Minnesota (290-2012-00016-I), RAND Corporation (290-2012-0006-I), RTI International and the University of North Carolina (290-2012-00008-I), and the Scientific Resource Center for the EPC Program (290-2012-00004-C).