NTP Technical Report on the Toxicity Studies of 3,3',4,4'-Tetrachloroazobenzene (CAS No. 14047-09-7) Administered by Gavage to F344/N Rats and B6C3F1 Mice
(Englisch)
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3,3',4,4'-Tetrachloroazobenzene is not commercially manufactured but is formed as an unwated byproduct in the manufacture of 3,4-dichloroanilineand its herbicidal derivatives Propanil, Linuron, and Diuron. In addition, environmental contamination by 3,3',4,4'-tetrachlo rozaobenzeneoccurs from the degradation of chloranilide herbicides and the photolysis and biolysis of 3,4-dichloraniline. 3,3',4,4'-Tetrachloroazobenzene was nominated by the United States Environmental Protection Agency for toxicity testing based on concerns over the potential for human exposure, the structural resemblance to 2,3,7,8-tetrachloro dibenzo-p-dioxin, and the reported dioxin-like effectof 3,3',4,4'-tetrachloroazobenzene. The toxicity of 3,3',4,4'-tetrachloroazobenzene was evaluated in 16-day and 13-week gavage studies in male and female F344/N rats and B6C34F1 mice. In addition to histopathology, evaluations included hematology (rats only),clinical chemistry, thyroid hormone analyses (rats only), cytochrome P(sub 450)1A immunohistochemical staining in the liver (rats only), and assessments of male reproductive endpoints and estrous cycle length. Genetic toxicology studies included mutagenicity tests in Salmonella typhimurium and the determination of micronuclei in mouse bone marrow and peripheral blood erythrocytes.
NTP Technical Report on the Toxicity Studies of 3,3',4,4'-Tetrachloroazobenzene (CAS No. 14047-09-7) Administered by Gavage to F344/N Rats and B6C3F1 Mice