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Eight subjects were isolated from the outside world for 26 days, during which two time zone shifts were performed and seven days of six degree down tilt were achieved simulating weightlessness. The results show that the method to achieve time zone change by gradually shortening the day for one hour over a period of seven days is a valid procedure to accomplish a seven hour time zone shift in a easterly direction for some body functions such as heat rate and sodium excretion. Other parameters such as temperature and hydroxylmelatoninsulfate excretion only adapted during weightlessness simulation. The results show that the method did not achieve ideal adaptation of all circadian rhythms in the evaluated parameters at the simulated spaceflight launch date.