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The effects of perspective change and familiarity upon lateral asymmetry for a face recognition task are analyzed based on the results of several experiments. A four choice match-to-sample procedure involved frontal target perspective faces and choice sets which contained faces in either front perspective, 3/4 perspective, or side perspective faces. The study assesses the effects of stimulus familiarity and distinctiveness. Results taken from analysis of variance, multidimensional scaling, and hierarchical cluster analysis suggests complex relationships between the sensitivity of faces and the ensuing development of familiarity. Conclusions are drawn in terms of implications for interpreting higher order cognition in laterality studies. Keywords: Hemispheric asymmetry, Visual recognition, Cerebral cortex, Human performance, Multi-dimensional scaling, Hierarchical cluster analysis. (kr)