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This issue contains a literature review entitled 'Production and Application of Immobilized Enzymes' by A. Kostner and M. Kreen of the Estonian Scientific Research Institute of Scientific and Technological Information and Technical Economic Studies. A special article by Herbert K.Y. Lau and G.G. Guilbault entitled 'Fluorometric Methods of Clinical Analysis on Silicone Rubber Pads' is also included. Additional items are: a listing of new grants; news items; a listing of received thesis abstracts and preprints; summaries of papers presented at the Second NSF Enzyme Grantees Conference; listings of enzyme companies, consultants, patents, and publications; a report on the Enzyme Engineering Users Conference held at Rutgers University, December 7, 1973; and a schedule of forthcoming meetings.