The purpose of Safety and Mission Assurance (SMA) at NASA’s Jet Propulsion Laboratory is to ensure mission safety and success. As the complexity of technical systems increases, the tools, processes, and infrastructure used to facilitate SMA activities must evolve. A transition from a document-centric approach to a data-driven, model-based architecture is critical in allowing SMA efforts to grapple with complex system designs. This work describes how a sample subset of existing SMA processes can be executed in a model-based environment, while also describing ways in which a model-based architecture can further augment SMA efforts. One key aspect is supporting the complex interplay between the different SMA processes and the systems engineering effort to provide additional insight into the system from an SMA perspective. The proposed architecture for model-based mission assurance provides an avenue for assuring mission safety and success in increasingly complex systems.