The Crew Module Uprighting System (CMUS) for the Orion Crew Module (CM) includes five bags that inflate after splashdown to rotate and upright the CM as necessary. Wave conditions can be severe enough to damage the bags and tethers, which could make the recovery operation hazardous. The CMUS therefore has design limits that ultimately constrain where the CM can land based upon sea conditions. This manuscript describes a full fluid-structure interaction computational model being used for the CMUS. It is a finite element model that uses explicit time integration to directly simulate uprighting, a computational approach usually reserved for short duration, highly transient phenomena and novelly applied here. The goal of this current effort is to determine the feasibility of this approach for CMUS uprighting, and to estimate the loads the CMUS bags experience in different wave conditions. The results from this work will be used to supplement other experimental and computational data in support of NASA’s Artemis program.