Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease (Englisch)
- Neue Suche nach: Toledo-Sherman, Leticia M
- Neue Suche nach: Toledo-Sherman, Leticia M
- Neue Suche nach: Prime, Michael E
- Neue Suche nach: Mrzljak, Ladislav
- Neue Suche nach: Beconi, Maria G
- Neue Suche nach: Beresford, Alan
- Neue Suche nach: Brookfield, Frederick A
- Neue Suche nach: Brown, Christopher J
- Neue Suche nach: Cardaun, Isabell
- Neue Suche nach: Courtney, Stephen M
- Neue Suche nach: Dijkman, Ulrike
- Neue Suche nach: Hamelin-Flegg, Estelle
- Neue Suche nach: Johnson, Peter D
- Neue Suche nach: Kempf, Valerie
- Neue Suche nach: Lyons, Kathy
- Neue Suche nach: Matthews, Kimberly
- Neue Suche nach: Mitchell, William L
- Neue Suche nach: O'Connell, Catherine
- Neue Suche nach: Pena, Paula
- Neue Suche nach: Powell, Kendall
- Neue Suche nach: Rassoulpour, Arash
- Neue Suche nach: Reed, Laura
- Neue Suche nach: Reindl, Wolfgang
- Neue Suche nach: Selvaratnam, Suganathan
- Neue Suche nach: Friley, Weslyn Ward
- Neue Suche nach: Weddell, Derek A
- Neue Suche nach: Went, Naomi E
- Neue Suche nach: Wheelan, Patricia
- Neue Suche nach: Winkler, Christin
- Neue Suche nach: Winkler, Dirk
- Neue Suche nach: Wityak, John
- Neue Suche nach: Yarnold, Christopher J
- Neue Suche nach: Yates, Dawn
- Neue Suche nach: Munoz-Sanjuan, Ignacio
- Neue Suche nach: Dominguez, Celia
In:
Journal of medicinal chemistry
;
58
, 3
; 1159
;
2015
-
ISSN:
- Aufsatz (Zeitschrift) / Print
-
Titel:Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease
-
Beteiligte:
-
Erschienen in:Journal of medicinal chemistry ; 58, 3 ; 1159
-
Verlag:
- Neue Suche nach: American Chemical Society
-
Erscheinungsort:Easton, Pa.
-
Erscheinungsdatum:2015
-
ISSN:
-
ZDBID:
-
Medientyp:Aufsatz (Zeitschrift)
-
Format:Print
-
Sprache:Englisch
- Neue Suche nach: 770/4230
- Neue Suche nach: 44.42 / 44.42
- Weitere Informationen zu Basisklassifikation
-
Schlagwörter:
-
Klassifikation:
-
Datenquelle:
Inhaltsverzeichnis – Band 58, Ausgabe 3
Zeige alle Jahrgänge und Ausgaben
Die Inhaltsverzeichnisse werden automatisch erzeugt und basieren auf den im Index des TIB-Portals verfügbaren Einzelnachweisen der enthaltenen Beiträge. Die Anzeige der Inhaltsverzeichnisse kann daher unvollständig oder lückenhaft sein.
- 1019
-
Computational Methods for Medicinal ChemistryBajorath, Jürgen / Jiang, Hualiang / Shoichet, Brian K. / Walters, W. Patrick et al. | 2015
- 1020
-
Glucagon-like Peptide‑1 (GLP-1) Analogs: Recent Advances, New Possibilities, and Therapeutic ImplicationsManandhar, Bikash / Ahn, Jung-Mo et al. | 2015
- 1038
-
Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer TreatmentZhao, Yujun / Aguilar, Angelo / Bernard, Denzil / Wang, Shaomeng et al. | 2015
- 1053
-
Nintedanib: From Discovery to the ClinicRoth, Gerald J. / Binder, Rudolf / Colbatzky, Florian / Dallinger, Claudia / Schlenker-Herceg, Rozsa / Hilberg, Frank / Wollin, Stefan-Lutz / Kaiser, Rolf et al. | 2015
- 1064
-
Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase Open New Prospects for the Treatment of Neurological DisordersAnnedi, Subhash C. et al. | 2015
- 1067
-
Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide SynthaseMukherjee, Paramita / Li, Huiying / Sevrioukova, Irina / Chreifi, Georges / Martásek, Pavel / Roman, Linda J. / Poulos, Thomas L. / Silverman, Richard B. et al. | 2015
- 1089
-
Pachymodulin, a New Functional Formyl Peptide Receptor 2 Peptidic Ligand Isolated from Frog Skin Has Janus-like Immunomodulatory CapacitiesLacombe, Claire / Piesse, Christophe / Sagan, Sandrine / Combadière, Christophe / Rosenstein, Yvonne / Auvynet, Constance et al. | 2015
- 1100
-
A Series of Novel Terpyridine-Skeleton Molecule Derivants Inhibit Tumor Growth and Metastasis by Targeting TopoisomerasesKwon, Han-Byeol / Park, Chanmi / Jeon, Kyung-Hwa / Lee, Eunyoung / Park, So-Eun / Jun, Kyu-Yeon / Kadayat, Tara Man / Thapa, Pritam / Karki, Radha / Na, Younghwa et al. | 2015
- 1123
-
Design, Synthesis, X‑ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate DehydrogenaseZhu, Junsheng / Han, Le / Diao, Yanyan / Ren, Xiaoli / Xu, Minghao / Xu, Liuxin / Li, Shiliang / Li, Qiang / Dong, Dong / Huang, Jin et al. | 2015
- 1140
-
Design, Synthesis, and Biological Evaluation of Sulfonyl Acrylonitriles as Novel Inhibitors of Cancer Metastasis and SpreadShen, Yi / Zificsak, Craig A. / Shea, Jill E. / Lao, Xuegang / Bollt, Oana / Li, Xiufen / Lisko, Joseph G. / Theroff, Jay P. / Scaife, Courtney L. / Ator, Mark A. et al. | 2015
- 1159
-
Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s DiseaseToledo-Sherman, Leticia M. / Prime, Michael E. / Mrzljak, Ladislav / Beconi, Maria G. / Beresford, Alan / Brookfield, Frederick A. / Brown, Christopher J. / Cardaun, Isabell / Courtney, Stephen M. / Dijkman, Ulrike et al. | 2015
- 1184
-
Highly Selective Salicylketoxime-Based Estrogen Receptor β Agonists Display Antiproliferative Activities in a Glioma ModelPaterni, Ilaria / Bertini, Simone / Granchi, Carlotta / Tuccinardi, Tiziano / Macchia, Marco / Martinelli, Adriano / Caligiuri, Isabella / Toffoli, Giuseppe / Rizzolio, Flavio / Carlson, Kathryn E. et al. | 2015
- 1195
-
Effect of Size and N‑Terminal Residue Characteristics on Bacterial Cell Penetration and Antibacterial Activity of the Proline-Rich Peptide Bac7Guida, Filomena / Benincasa, Monica / Zahariev, Sotir / Scocchi, Marco / Berti, Federico / Gennaro, Renato / Tossi, Alessandro et al. | 2015
- 1205
-
Promiscuous 2‑Aminothiazoles (PrATs): A Frequent Hitting ScaffoldDevine, Shane M. / Mulcair, Mark D. / Debono, Cael O. / Leung, Eleanor W. W. / Nissink, J. Willem M. / Lim, San Sui / Chandrashekaran, Indu R. / Vazirani, Mansha / Mohanty, Biswaranjan / Simpson, Jamie S. et al. | 2015
- 1215
-
Antibacterial Drug Leads: DNA and Enzyme MultitargetingZhu, Wei / Wang, Yang / Li, Kai / Gao, Jian / Huang, Chun-Hsiang / Chen, Chun-Chi / Ko, Tzu-Ping / Zhang, Yonghui / Guo, Rey-Ting / Oldfield, Eric et al. | 2015
- 1228
-
Exploration of Cyanine Compounds as Selective Inhibitors of Protein Arginine Methyltransferases: Synthesis and Biological EvaluationHu, Hao / Owens, Eric A. / Su, Hairui / Yan, Leilei / Levitz, Andrew / Zhao, Xinyang / Henary, Maged / Zheng, Yujun George et al. | 2015
- 1244
-
SAR-Guided Development and Characterization of a Potent Antitumor Compound toward B‑Cell Neoplasms with No Detectable Cytotoxicity toward Healthy CellsBrunhofer-Bolzer, Gerda / Le, Trang / Dyckmanns, Nils / Knaus, Hanna A. / Pausz, Clemens / Freund, Patricia / Jäger, Ulrich / Erker, Thomas / Vanura, Katrina et al. | 2015
- 1254
-
Design and Synthesis of Potent and Multifunctional Aldose Reductase Inhibitors Based on QuinoxalinonesQin, Xiangyu / Hao, Xin / Han, Hui / Zhu, Shaojuan / Yang, Yanchun / Wu, Bobin / Hussain, Saghir / Parveen, Shagufta / Jing, Chaojun / Ma, Bing et al. | 2015
- 1268
-
Oleanane Triterpenes from the Flowers of Camellia japonica Inhibit Porcine Epidemic Diarrhea Virus (PEDV) ReplicationYang, Jun-Li / Ha, Thi-Kim-Quy / Dhodary, Basanta / Pyo, Euisun / Nguyen, Ngoc Hieu / Cho, Hyomoon / Kim, Eunhee / Oh, Won Keun et al. | 2015
- 1281
-
Fragment-Based Drug Discovery of 2‑Thiazolidinones as BRD4 Inhibitors: 2. Structure-Based OptimizationZhao, Lele / Wang, Yingqing / Cao, Danyan / Chen, Tiantian / Wang, Qi / Li, Yanlian / Xu, Yechun / Zhang, Naixia / Wang, Xin / Chen, Danqi et al. | 2015
- 1298
-
Development of Potent Inhibitors of Pyocyanin Production in Pseudomonas aeruginosaMiller, Laura C. / O’Loughlin, Colleen T. / Zhang, Zinan / Siryaporn, Albert / Silpe, Justin E. / Bassler, Bonnie L. / Semmelhack, Martin F. et al. | 2015
- 1307
-
Novel 3‑Nitrotriazole-Based Amides and Carbinols as Bifunctional Antichagasic AgentsPapadopoulou, Maria V. / Bloomer, William D. / Lepesheva, Galina I. / Rosenzweig, Howard S. / Kaiser, Marcel / Aguilera-Venegas, Benjamín / Wilkinson, Shane R. / Chatelain, Eric / Ioset, Jean-Robert et al. | 2015
- 1320
-
Dual Antitumor and Antiangiogenic Activity of Organoplatinum(II) ComplexesZamora, Ana / Pérez, Sergio A. / Rodríguez, Venancio / Janiak, Christoph / Yellol, Gorakh S. / Ruiz, José et al. | 2015
- 1337
-
Design, Synthesis, and Biological Evaluation of Tetrazole Analogs of Cl-Amidine as Protein Arginine Deiminase InhibitorsSubramanian, Venkataraman / Knight, Jason S. / Parelkar, Sangram / Anguish, Lynne / Coonrod, Scott A. / Kaplan, Mariana J. / Thompson, Paul R. et al. | 2015
- 1345
-
Design, Synthesis, and Biological Evaluation of Combretabenzodiazepines: A Novel Class of Anti-Tubulin AgentsGalli, Ubaldina / Travelli, Cristina / Aprile, Silvio / Arrigoni, Elena / Torretta, Simone / Grosa, Giorgio / Massarotti, Alberto / Sorba, Giovanni / Canonico, Pier Luigi / Genazzani, Armando A. et al. | 2015
- 1358
-
Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2‑Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl‑1H‑imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric DiseasesJaeschke, Georg / Kolczewski, Sabine / Spooren, Will / Vieira, Eric / Bitter-Stoll, Nadia / Boissin, Patrick / Borroni, Edilio / Büttelmann, Bernd / Ceccarelli, Simona / Clemann, Nicole et al. | 2015
- 1372
-
Glycosylated Enfuvirtide: A Long-Lasting Glycopeptide with Potent Anti-HIV ActivityCheng, Shuihong / Chang, Xuesong / Wang, Yan / Gao, George F. / Shao, Yiming / Ma, Liying / Li, Xuebing et al. | 2015
- 1380
-
Structure–Activity Relationship for the Oxadiazole Class of AntibioticsSpink, Edward / Ding, Derong / Peng, Zhihong / Boudreau, Marc A. / Leemans, Erika / Lastochkin, Elena / Song, Wei / Lichtenwalter, Katerina / O’Daniel, Peter I. / Testero, Sebastian A. et al. | 2015
- 1390
-
Synthetic Peptides Reproducing Tissue Transglutaminase–Gliadin Complex Neo-epitopes as Probes for Antibody Detection in Celiac Disease Patients’ SeraDi Pisa, Margherita / Pascarella, Simona / Scrima, Mario / Sabatino, Giuseppina / Real-Fernández, Feliciana / Chelli, Mario / Renzi, Daniela / Calabrò, Antonio / D’Ursi, Anna Maria / Papini, Anna Maria et al. | 2015
- 1400
-
Novel Arylalkenylpropargylamines as Neuroprotective, Potent, and Selective Monoamine Oxidase B Inhibitors for the Treatment of Parkinson’s DiseaseHuleatt, Paul B. / Khoo, Mui Ling / Chua, Yi Yuan / Tan, Tiong Wei / Liew, Rou Shen / Balogh, Balázs / Deme, Ruth / Gölöncsér, Flóra / Magyar, Kalman / Sheela, David P. et al. | 2015
- 1420
-
Simple Method Provides Resolution of Albumin, Lipoprotein, Free Fraction, and Chylomicron To Enhance the Utility of Protein Binding AssaysBrockman, Adam H. / Oller, Haley R. / Moreau, Benoît / Kriksciukaite, Kristina / Bilodeau, Mark T. et al. | 2015
- 1426
-
Discovery of 1H‑Pyrazol-3(2H)‑ones as Potent and Selective Inhibitors of Protein Kinase R‑like Endoplasmic Reticulum Kinase (PERK)Smith, Adrian L. / Andrews, Kristin L. / Beckmann, Holger / Bellon, Steven F. / Beltran, Pedro J. / Booker, Shon / Chen, Hao / Chung, Young-Ah / D’Angelo, Noel D. / Dao, Jennifer et al. | 2015
- 1442
-
Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) ComplexesSenerovic, Lidija / Zivkovic, Marija D. / Veselinovic, Aleksandar / Pavic, Aleksandar / Djuran, Milos I. / Rajkovic, Snezana / Nikodinovic-Runic, Jasmina et al. | 2015
- 1452
-
Function-Oriented Development of CXCR4 Antagonists as Selective Human Immunodeficiency Virus (HIV)‑1 Entry InhibitorsWu, Chien-Huang / Wang, Chuan-Jen / Chang, Chun-Ping / Cheng, Yung-Chi / Song, Jen-Shin / Jan, Jiing-Jyh / Chou, Ming-Chen / Ke, Yi-Yu / Ma, Jing / Wong, Ying-Chieh et al. | 2015
- 1466
-
Discovery of Small Molecule Inhibitors to Krüppel-like Factor 10 (KLF10): Implications for Modulation of T Regulatory Cell DifferentiationKhedkar, Santosh A. / Sun, Xinghui / Rigby, Alan C. / Feinberg, Mark W. et al. | 2015
- 1479
-
Novel 5‑Substituted Pyrrolo[2,3‑d]pyrimidines as Dual Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5‑Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase and as Potential Antitumor AgentsWang, Yiqiang / Mitchell-Ryan, Shermaine / Raghavan, Sudhir / George, Christina / Orr, Steven / Hou, Zhanjun / Matherly, Larry H. / Gangjee, Aleem et al. | 2015
- 1494
-
Carbonic Anhydrase Inhibitors with Dual-Tail Moieties To Match the Hydrophobic and Hydrophilic Halves of the Carbonic Anhydrase Active SiteTanpure, Rajendra P. / Ren, Bin / Peat, Thomas S. / Bornaghi, Laurent F. / Vullo, Daniela / Supuran, Claudiu T. / Poulsen, Sally-Ann et al. | 2015
- 1502
-
2‑(2-Oxo-morpholin-3-yl)-acetamide Derivatives as Broad-Spectrum Antifungal AgentsBardiot, Dorothée / Thevissen, Karin / De Brucker, Katrijn / Peeters, Annelies / Cos, Paul / Taborda, Carlos P. / McNaughton, Michael / Maes, Louis / Chaltin, Patrick / Cammue, Bruno P. A. et al. | 2015
- 1513
-
Synthesis and Evaluation of 4‑Halogeno‑N‑[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]‑N‑[11C]methylbenzamide for Imaging of Metabotropic Glutamate 1 Receptor in MelanomaFujinaga, Masayuki / Xie, Lin / Yamasaki, Tomoteru / Yui, Joji / Shimoda, Yoko / Hatori, Akiko / Kumata, Katsushi / Zhang, Yiding / Nengaki, Nobuki / Kawamura, Kazunori et al. | 2015
- 1524
-
3,4-Diaminobenzoic Acid Derivatives as Inhibitors of the Oxytocinase Subfamily of M1 Aminopeptidases with Immune-Regulating PropertiesPapakyriakou, Athanasios / Zervoudi, Efthalia / Tsoukalidou, Sofia / Mauvais, Francois-Xavier / Sfyroera, Georgia / Mastellos, Dimitrios C. / van Endert, Peter / Theodorakis, Emmanuel A. / Vourloumis, Dionisios / Stratikos, Efstratios et al. | 2015
- 1544
-
Identification of the Minimum Peptide from Mouse Myostatin Prodomain for Human Myostatin InhibitionTakayama, Kentaro / Noguchi, Yuri / Aoki, Shin / Takayama, Shota / Yoshida, Momoko / Asari, Tomo / Yakushiji, Fumika / Nishimatsu, Shin-ichiro / Ohsawa, Yutaka / Itoh, Fumiko et al. | 2015
- 1550
-
Proof of Concept Study for Designed Multiple Ligands Targeting the Dopamine D2, Serotonin 5‑HT2A, and Muscarinic M1 Acetylcholine ReceptorsSzabo, Monika / Lim, Herman D. / Klein Herenbrink, Carmen / Christopoulos, Arthur / Lane, J. Robert / Capuano, Ben et al. | 2015
- 1556
-
Discovery of Potent Heterodimeric Antagonists of Inhibitor of Apoptosis Proteins (IAPs) with Sustained Antitumor ActivityPerez, Heidi L. / Chaudhry, Charu / Emanuel, Stuart L. / Fanslau, Caroline / Fargnoli, Joseph / Gan, Jinping / Kim, Kyoung S. / Lei, Ming / Naglich, Joseph G. / Traeger, Sarah C. et al. | 2015
- 1563
-
A High-Throughput Screen Reveals New Small-Molecule Activators and Inhibitors of Pantothenate KinasesSharma, Lalit Kumar / Leonardi, Roberta / Lin, Wenwei / Boyd, Vincent A. / Goktug, Asli / Shelat, Anang A. / Chen, Taosheng / Jackowski, Suzanne / Rock, Charles O. et al. | 2015
- 1569
-
Synthesis and Biological Evaluation of Second-Generation Tropanol-Based Androgen Receptor ModulatorsSundén, Henrik / Holland, Mareike C. / Poutiainen, Pekka K. / Jääskeläinen, Tiina / Pulkkinen, Juha T. / Palvimo, Jorma J. / Olsson, Roger et al. | 2015
- 1575
-
Design, Synthesis, and Characterization of Fatty Acid Derivatives of a Dimeric Peptide-Based Postsynaptic Density-95 (PSD-95) InhibitorNissen, Klaus B. / Andersen, Julie J. / Haugaard-Kedström, Linda M. / Bach, Anders / Strømgaard, Kristian et al. | 2015