Repurposing CD8+ T cell immunity against SARS-CoV-2 for cancer immunotherapy: a positive aspect of the COVID-19 pandemic? (Englisch)
Freier Zugriff
- Neue Suche nach: Gujar, Shashi
- Neue Suche nach: Pol, Jonathan G.
- Neue Suche nach: Kim, Youra
- Neue Suche nach: Kroemer, Guido
- Neue Suche nach: Gujar, Shashi
- Neue Suche nach: Pol, Jonathan G.
- Neue Suche nach: Kim, Youra
- Neue Suche nach: Kroemer, Guido
In:
OncoImmunology
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9
, 1
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2020
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ISSN:
- Aufsatz (Zeitschrift) / Elektronische Ressource
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Titel:Repurposing CD8+ T cell immunity against SARS-CoV-2 for cancer immunotherapy: a positive aspect of the COVID-19 pandemic?
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Beteiligte:Gujar, Shashi ( Autor:in ) / Pol, Jonathan G. ( Autor:in ) / Kim, Youra ( Autor:in ) / Kroemer, Guido ( Autor:in )
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Erschienen in:OncoImmunology ; 9, 1
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Verlag:
- Neue Suche nach: Taylor & Francis
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Erscheinungsdatum:01.01.2020
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ISSN:
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DOI:
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Medientyp:Aufsatz (Zeitschrift)
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Format:Elektronische Ressource
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Sprache:Englisch
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Schlagwörter:
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Datenquelle:
Inhaltsverzeichnis – Band 9, Ausgabe 1
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Complement inhibitor factor H expressed by breast cancer cells differentiates CD14+ human monocytes into immunosuppressive macrophagesSmolag, Karolina I. / Mueni, Christine M. / Leandersson, Karin / Jirström, Karin / Hagerling, Catharina / Mörgelin, Matthias / Barlow, Paul N. / Martin, Myriam / Blom, Anna M. et al. | 2020
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Overproduction of IL-2 by Cbl-b deficient CD4+ T cells provides resistance against regulatory T cellsHan, SeongJun / Chung, Douglas C. / St. Paul, Michael / Liu, Zhe Qi / Garcia-Batres, Carlos / Elford, Alisha R. / Tran, Charles W. / Chapatte, Laurence / Ohashi, Pamela S. et al. | 2020
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Evaluation of PD-L1 expression on circulating tumor cells (CTCs) in patients with advanced urothelial carcinoma (UC)Bergmann, Sonja / Coym, Anja / Ott, Leonie / Soave, Armin / Rink, Michael / Janning, Melanie / Stoupiec, Malgorzata / Coith, Cornelia / Peine, Sven / von Amsberg, Gunhild et al. | 2020
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UniCAR T cell immunotherapy enables efficient elimination of radioresistant cancer cellsArndt, Claudia / Loureiro, Liliana R. / Feldmann, Anja / Jureczek, Justyna / Bergmann, Ralf / Máthé, Domokos / Hegedüs, Nikolett / Berndt, Nicole / Koristka, Stefanie / Mitwasi, Nicola et al. | 2020
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Tumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomasDancsok, Amanda R. / Gao, Dongxia / Lee, Anna F. / Steigen, Sonja Eriksson / Blay, Jean-Yves / Thomas, David M. / Maki, Robert G. / Nielsen, Torsten O. / Demicco, Elizabeth G. et al. | 2020
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Efficacy of adjuvant cytokine-induced killer cell immunotherapy in patients with colorectal cancer after radical resectionPan, Qiu-Zhong / Zhao, Jing-Jing / Yang, Chao-Pin / Zhou, Yu-Qing / Lin, Jun-Zhong / Tang, Yan / Gu, Jia-Mei / Wang, Qi-Jing / Li, Yong-Qiang / He, Jia et al. | 2020
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A meta-analysis comparing responses of Asian versus non-Asian cancer patients to PD-1 and PD-L1 inhibitor-based therapyPeng, Ling / Qin, Bao-Dong / Xiao, Kui / Xu, Song / Yang, Jin-Song / Zang, Yuan-Sheng / Stebbing, Justin / Xie, Li-Ping et al. | 2020
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Systemic inflammation is associated with circulating cell death released keratin 18 fragments in colorectal cancerSirniö, Päivi / Väyrynen, Juha P. / Mutt, Shivaprakash J. / Herzig, Karl-Heinz / Walkowiak, Jaroslaw / Klintrup, Kai / Mäkelä, Jyrki / Karttunen, Tuomo J. / Mäkinen, Markus J. / Tuomisto, Anne et al. | 2020
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Colon-specific immune microenvironment regulates cancer progression versus rejectionTrimaglio, Giulia / Tilkin-Mariamé, Anne-Françoise / Feliu, Virginie / Lauzéral-Vizcaino, Françoise / Tosolini, Marie / Valle, Carine / Ayyoub, Maha / Neyrolles, Olivier / Vergnolle, Nathalie / Rombouts, Yoann et al. | 2020
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Complete and long-lasting clinical responses in immune checkpoint inhibitor-resistant, metastasized melanoma treated with adoptive T cell transfer combined with DC vaccinationLövgren, Tanja / Wolodarski, Maria / Wickström, Stina / Edbäck, Ulrika / Wallin, Mette / Martell, Eva / Markland, Katrin / Blomberg, Pontus / Nyström, Maria / Lundqvist, Andreas et al. | 2020
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Human innate immune cell crosstalk induces melanoma cell senescenceFunck, Felix / Pahl, Jens / Kyjacova, Lenka / Freund, Lukas / Oehrl, Stephanie / Gräbe, Galina / Pezer, Silvia / Hassel, Jessica C. / Sleeman, Jonathan / Cerwenka, Adelheid et al. | 2020
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Expression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosisNugteren, Sandrine / Goos, Jeroen A.C.M. / Delis-van Diemen, Pien M. / Simons-Oosterhuis, Ytje / Lindenbergh-Kortleve, Dicky J. / van Haaften, Daniëlle H. / Sanders, Joyce / Meijer, Gerrit A. / Fijneman, Remond J.A. / Samsom, Janneke N. et al. | 2020
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MIF inhibition as a strategy for overcoming resistance to immune checkpoint blockade therapy in melanomade Azevedo, Ricardo A. / Shoshan, Einav / Whang, Shanzhi / Markel, Gal / Jaiswal, Ashvin R. / Liu, Arthur / Curran, Michael A. / Travassos, Luiz R. / Bar-Eli, Menashe et al. | 2020
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GD2-targeted chimeric antigen receptor T cells prevent metastasis formation by elimination of breast cancer stem-like cellsSeitz, Christian M. / Schroeder, Sarah / Knopf, Philipp / Krahl, Ann-Christin / Hau, Jana / Schleicher, Sabine / Martella, Manuela / Quintanilla-Martinez, Leticia / Kneilling, Manfred / Pichler, Bernd et al. | 2020
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Expression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneityKato, Shumei / Okamura, Ryosuke / Kumaki, Yuichi / Ikeda, Sadakatsu / Nikanjam, Mina / Eskander, Ramez / Goodman, Aaron / Lee, Suzanna / Glenn, Sean T. / Dressman, Devin et al. | 2020
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Immune-related adverse events are clustered into distinct subtypes by T-cell profiling before and early after anti-PD-1 treatmentKim, Kyung Hwan / Hur, Joon Young / Cho, Jinhyun / Ku, Bo Mi / Koh, Jiae / Koh, June Young / Sun, Jong-Mu / Lee, Se-Hoon / Ahn, Jin Seok / Park, Keunchil et al. | 2020
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Oncolytic poxvirus CF33-hNIS-ΔF14.5 favorably modulates tumor immune microenvironment and works synergistically with anti-PD-L1 antibody in a triple-negative breast cancer modelChaurasiya, Shyambabu / Yang, Annie / Kang, Seonah / Lu, Jianming / Kim, Sang-In / Park, Anthony K. / Sivanandam, Venkatesh / Zhang, Zhifang / Woo, Yanghee / Warner, Susanne G. et al. | 2020
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Lactate dehydrogenase: a marker of diminished antitumor immunityVan Wilpe, Sandra / Koornstra, Rutger / Den Brok, Martijn / De Groot, Jan Willem / Blank, Christian / De Vries, Jolanda / Gerritsen, Winald / Mehra, Niven et al. | 2020
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Immune co-culture cell microarray – a feasible tool for high-throughput functional investigation of lymphocyte–cancer interactionsBaruch, Erez Nissim / Ortenberg, Rona / Avivi, Camila / Anafi, Liat / Dick-Necula, Daniela / Stossel, Chani / Moshkovits, Yonatan / Itzhaki, Orit / Besser, Michal Judith / Schachter, Jacob et al. | 2020
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RRx-001, a first-in-class small molecule inhibitor of MYC and a downregulator of CD47, is an "erythrophagoimmunotherapeutic"Oronsky, Bryan / Carter, Corey A. / Caroen, Scott / Scribner, Curtis / Oronsky, Arnold / Reid, Tony R. et al. | 2020
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CD44v3 protein-carrying tumor-derived exosomes in HNSCC patients’ plasma as potential noninvasive biomarkers of disease activityTheodoraki, Marie-Nicole / Matsumoto, Akihiro / Beccard, Inga / Hoffmann, Thomas K. / Whiteside, Theresa L. et al. | 2020
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Dexamethasone premedication suppresses vaccine-induced immune responses against cancerVormehr, Mathias / Lehar, Sophie / Kranz, Lena M. / Tahtinen, Siri / Oei, Yoko / Javinal, Vincent / Delamarre, Lélia / Walzer, Kerstin C. / Diken, Mustafa / Kreiter, Sebastian et al. | 2020
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ROS1-fusion protein induces PD-L1 expression via MEK-ERK activation in non-small cell lung cancerLiu, Zheng / Zhao, Kejia / Wei, Shiyou / Liu, Chengwu / Zhou, Jiankang / Gou, Qiheng / Wu, Xia / Yang, Zhenyu / Yang, Yanbo / Peng, Yong et al. | 2020
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A rationally-engineered IL-2 improves the antitumor effect of anti-CD20 therapyCasadesús, Ana Victoria / Deligne, Claire / Diallo, Béré Kadjdiatou / Sosa, Katya / Josseaume, Nathalie / Mesa, Circe / León, Kalet / Hernández, Tays / Teillaud, Jean-Luc et al. | 2020
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Proliferative potential and response to nivolumab in clear cell renal cell carcinoma patientsZhang, Tian / Pabla, Sarabjot / Lenzo, Felicia L. / Conroy, Jeffrey M. / Nesline, Mary K. / Glenn, Sean T. / Papanicolau-Sengos, Antonios / Burgher, Blake / Giamo, Vincent / Andreas, Jonathan et al. | 2020
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Efficacy and safety of immune checkpoint inhibitors in patients with advanced non–small cell lung cancer (NSCLC): a systematic literature reviewWagner, Gernot / Stollenwerk, Hannah Karolina / Klerings, Irma / Pecherstorfer, Martin / Gartlehner, Gerald / Singer, Josef et al. | 2020
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Tumor-derived exosomes: the next generation of promising cell-free vaccines in cancer immunotherapyNaseri, Marzieh / Bozorgmehr, Mahmood / Zöller, Margot / Ranaei Pirmardan, Ehsan / Madjd, Zahra et al. | 2020
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The consensus immunoscore: toward a new classification of colorectal cancerLanzi, Anastasia / Pagès, Franck / Lagorce-Pagès, Christine / Galon, Jérôme et al. | 2020
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Lurbinectedin: an FDA-approved inducer of immunogenic cell death for the treatment of small-cell lung cancerKepp, Oliver / Zitvogel, Laurence / Kroemer, Guido et al. | 2020
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Mitochondrial control of innate immune signaling by irradiated cancer cellsYamazaki, Takahiro / Galluzzi, Lorenzo et al. | 2020
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Characterization of the human tumor microbiome reveals tumor-type specific intra-cellular bacteriaLivyatan, Ilana / Nejman, Deborah / Shental, Noam / Straussman, Ravid et al. | 2020
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Intratumoral CCR5+ neutrophils identify immunogenic subtype muscle-invasive bladder cancer with favorable prognosis and therapeutic responsesXiang, Zhuoyi / Zhou, Quan / Zeng, Han / Wang, Zewei / Zhang, Hongyu / Liu, Zhaopei / Huang, Qiuren / Chang, Yuan / Bai, Qi / Xia, Yu et al. | 2020
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The consensus Immunoscore in phase 3 clinical trials; potential impact on patient management decisionsPagès, Franck / Taieb, Julien / Laurent-Puig, Pierre / Galon, Jérôme et al. | 2020
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IAP inhibitor, Embelin increases VCAM-1 levels on the endothelium, producing lymphocytic infiltration and antitumor immunityNakajima, Kosei / Ino, Yoshinori / Yamazaki-Itoh, Rie / Naito, Chie / Shimasaki, Mari / Takahashi, Mami / Esaki, Minoru / Nara, Satoshi / Kishi, Yoji / Shimada, Kazuaki et al. | 2020
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Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4Choi, Sung Hee / Barker, Emily C. / Gerber, Kyle J. / Letterio, John J. / Kim, Byung-Gyu et al. | 2020
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Quantitative MRI cell tracking of immune cell recruitment to tumors and draining lymph nodes in response to anti-PD-1 and a DPX-based immunotherapyTremblay, Marie-Laurence / O’Brien-Moran, Zoe / Rioux, James A. / Nuschke, Andrea / Davis, Christa / Kast, W. Martin / Weir, Genevieve / Stanford, Marianne / Brewer, Kimberly D. et al. | 2020
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Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapiesMa, Yuting / Yang, Heng / Kroemer, Guido et al. | 2020
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Tumor-targeting oncolytic virus elicits potent immunotherapeutic vaccine responses to tumor antigensLuo, Yong / Lin, Chaolong / Zou, Yidi / Ju, Fei / Ren, Wenfeng / Lin, Yanhua / Wang, Yale / Huang, Xiaoxuan / Liu, Huiling / Yu, Zeng et al. | 2020
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Valproic acid attenuates CCR2-dependent tumor infiltration of monocytic myeloid-derived suppressor cells, limiting tumor progressionXie, Zhiqi / Ikegami, Tamami / Ago, Yukio / Okada, Naoki / Tachibana, Masashi et al. | 2020
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Blockade of programmed cell death protein 1 (PD-1) in Sézary syndrome reduces Th2 phenotype of non-tumoral T lymphocytes but may enhance tumor proliferationSaulite, Ieva / Ignatova, Desislava / Chang, Yun-Tsan / Fassnacht, Christina / Dimitriou, Florentia / Varypataki, Eleni / Anzengruber, Florian / Nägeli, Mirjam / Cozzio, Antonio / Dummer, Reinhard et al. | 2020
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Identifying optimal first-line interventions for advanced non-small cell lung carcinoma according to PD-L1 expression: a systematic review and network meta-analysisLiu, Jie / Li, Chengming / Seery, Samuel / Yu, Jinming / Meng, Xue et al. | 2020
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Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune responseSong, Mei / Wang, Chao / Wang, Huan / Zhang, Tuo / Li, Jiuqi / Benezra, Robert / Chouchane, Lotfi / Sun, Yin-Hao / Cui, Xin-Gang / Ma, Xiaojing et al. | 2020
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T cell receptor repertoire as a prognosis marker for heat shock protein peptide complex-96 vaccine trial against newly diagnosed glioblastomaZhang, Yang / Mudgal, Poorva / Wang, Liuyang / Wu, Haiyang / Huang, Na / Alexander, Peter B. / Gao, Zhixian / Ji, Nan / Li, Qi-Jing et al. | 2020
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MMP2 as an independent prognostic stratifier in oral cavity cancersHoffmann, Caroline / Vacher, Sophie / Sirven, Philémon / Lecerf, Charlotte / Massenet, Lucile / Moreira, Aurélie / Surun, Aurore / Schnitzler, Anne / Klijanienko, Jerzy / Mariani, Odette et al. | 2020
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Intravital imaging reveals synergistic effect of CAR T-cells and radiation therapy in a preclinical immunocompetent glioblastoma modelMurty, Surya / Haile, Samuel T. / Beinat, Corinne / Aalipour, Amin / Alam, Israt S. / Murty, Tara / Shaffer, Travis M. / Patel, Chirag B. / Graves, Edward E. / Mackall, Crystal L. et al. | 2020
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A novel gene signature to predict immune infiltration and outcome in patients with prostate cancerShao, Ning / Tang, Hong / Mi, Yuanyuan / Zhu, Yao / Wan, Fangning / Ye, Dingwei et al. | 2020
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Anti-EGF antibodies as surrogate biomarkers of clinical efficacy in stage IIIB/IV non-small-cell lung cancer patients treated with an optimized CIMAvax-EGF vaccination schedulePopa, Xitlally / García, Beatriz / Fuentes, Karla P. / Huerta, Vivian / Alvarez, Karen / Viada, Carmen E. / Neninger, Elia / Rodríguez, Pedro C. / González, Zuyen / González, Amnely et al. | 2020
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Cancer immunotherapy using a polysaccharide from Codium fragile in a murine modelPark, Hae-Bin / Lim, Seong-Min / Hwang, Juyoung / Zhang, Wei / You, SangGuan / Jin, Jun-O et al. | 2020
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Identification of miR-200a-5p targeting the peptide transporter TAP1 and its association with the clinical outcome of melanoma patientsLazaridou, Maria-Filothei / Gonschorek, Evamaria / Massa, Chiara / Friedrich, Michael / Handke, Diana / Mueller, Anja / Jasinski-Bergner, Simon / Dummer, Reinhard / Koelblinger, Peter / Seliger, Barbara et al. | 2020
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Inflammation and lymphocyte infiltration are associated with shorter survival in patients with high-grade gliomaMarinari, Eliana / Allard, Mathilde / Gustave, Robin / Widmer, Valérie / Philippin, Géraldine / Merkler, Doron / Tsantoulis, Petros / Dutoit, Valérie / Dietrich, Pierre-Yves et al. | 2020
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Identification of tumor-infiltrating immune cells and prognostic validation of tumor-infiltrating mast cells in adrenocortical carcinoma: results from bioinformatics and real-world dataTian, Xi / Xu, Wenhao / Wang, Yuchen / Anwaier, Aihetaimujiang / Wang, Hongkai / Wan, Fangning / Zhu, Yu / Cao, Dalong / Shi, Guohai / Zhu, Yiping et al. | 2020
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Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapyFeldmann, Anja / Hoffmann, Anja / Bergmann, Ralf / Koristka, Stefanie / Berndt, Nicole / Arndt, Claudia / Rodrigues Loureiro, Liliana / Kittel-Boselli, Enrico / Mitwasi, Nicola / Kegler, Alexandra et al. | 2020
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Combination treatments with hydroxychloroquine and azithromycin are compatible with the therapeutic induction of anticancer immune responsesLiu, Peng / Zhao, Liwei / Ferrere, Gladys / Alves-Costa-Silva, Carolina / Ly, Pierre / Wu, Qi / Tian, Ai-Ling / Derosa, Lisa / Zitvogel, Laurence / Kepp, Oliver et al. | 2020
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Trial Watch: experimental TLR7/TLR8 agonists for oncological indicationsFrega, Giorgio / Wu, Qi / Le Naour, Julie / Vacchelli, Erika / Galluzzi, Lorenzo / Kroemer, Guido / Kepp, Oliver et al. | 2020
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IDH-mutant gliomas harbor fewer regulatory T cells in humans and miceRichardson, Leland G. / Nieman, Linda T. / Stemmer-Rachamimov, Anat O. / Zheng, Xijin S. / Stafford, Khalifa / Nagashima, Hiroaki / Miller, Julie J. / Kiyokawa, Juri / Ting, David T. / Wakimoto, Hiroaki et al. | 2020
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Pirfenidone facilitates immune infiltration and enhances the antitumor efficacy of PD-L1 blockade in miceQin, Wan / Zou, Jun / Huang, Yongbiao / Liu, Chaofan / Kang, Yalin / Han, Hu / Tang, Yang / Li, Long / Liu, Bo / Zhao, Weiheng et al. | 2020
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Improving the anti-solid tumor efficacy of CAR-T cells by inhibiting adenosine signaling pathwayLi, Na / Tang, Na / Cheng, Chen / Hu, Tao / Wei, Xiaofei / Han, Weidong / Wang, Haoyi et al. | 2020
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Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancerTinholt, Mari / Stavik, Benedicte / Tekpli, Xavier / Garred, Øystein / Borgen, Elin / Kristensen, Vessela / Sahlberg, Kristine Kleivi / Sandset, Per Morten / Iversen, Nina et al. | 2020
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Tivozanib mediated inhibition of c-Kit/SCF signaling on Tregs and MDSCs and reversal of tumor induced immune suppression correlates with survival of HCC patientsKalathil, Suresh Gopi / Wang, Katy / Hutson, Alan / Iyer, Renuka / Thanavala, Yasmin et al. | 2020
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Single-cell analysis reveals immune modulation and metabolic switch in tumor-draining lymph nodesLi, Yen-Liang / Chen, Chung-Hsing / Chen, Jing-Yi / Lai, You-Syuan / Wang, Shao-Chun / Jiang, Shih-Sheng / Hung, Wen-Chun et al. | 2020
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Immune infiltration and immune gene signature predict the response to fluoropyrimidine-based chemotherapy in colorectal cancer patientsMo, Xianwei / Huang, Xiaoliang / Feng, Yan / Wei, Chunyin / Liu, Haizhou / Ru, Haiming / Qin, Haiquan / Lai, Hao / Wu, Guo / Xie, Weishun et al. | 2020
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Regulatory approval of photoimmunotherapy: photodynamic therapy that induces immunogenic cell deathGomes-da-Silva, Lígia C. / Kepp, Oliver / Kroemer, Guido et al. | 2020
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Hist-Immune signature: a prognostic factor in colorectal cancer using immunohistochemical slide image analysisZhao, Ke / Li, Zhenhui / Li, Yong / Yao, Su / Huang, Yanqi / Wang, Yingyi / Zhang, Fang / Wu, Lin / Chen, Xin / Liang, Changhong et al. | 2020
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Establishment and validation of an immunodiagnostic model for prediction of breast cancerQiu, Cuipeng / Wang, Peng / Wang, Bofei / Shi, Jianxiang / Wang, Xiao / Li, Tiandong / Qin, Jiejie / Dai, Liping / Ye, Hua / Zhang, Jianying et al. | 2020
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Destroy, what destroys youLuu, Khang / Nickles, Emily / Schwarz, Herbert et al. | 2020
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In the mix: the potential benefits of adding GM-CSF to CpG-B in the local treatment of patients with early-stage melanomaKoster, Bas D. / de Jong, Tamarah D. / van den Hout, Mari F. C. M. / Sluijter, Berbel J. R. / Vuylsteke, Ronald J. C. L. M. / Molenkamp, Barbara G. / Vosslamber, Saskia / van den Tol, M. Petrousjka / van den Eertwegh, Alfons J. M. / de Gruijl, Tanja D. et al. | 2020
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Moderate-to-severe eosinophilia induced by treatment with immune checkpoint inhibitors: 37 cases from a national reference center for hypereosinophilic syndromes and the French pharmacovigilance databaseScanvion, Quentin / Béné, Johana / Gautier, Sophie / Grandvuillemin, Aurélie / Le Beller, Christine / Chenaf, Chouki / Etienne, Nicolas / Brousseau, Solenn / Cortot, Alexis B. / Mortier, Laurent et al. | 2020
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S100A4 promotes hepatocellular carcinogenesis by intensifying fibrosis-associated cancer cell stemnessLi, Yanan / Wang, Jun / Song, Kun / Liu, Shuangqing / Zhang, Huilei / Wang, Fei / Ni, Chen / Zhai, Wenlong / Liang, Jialu / Qin, Zhihai et al. | 2020
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Eosinophil accumulation predicts response to melanoma treatment with immune checkpoint inhibitorsSimon, Sonja C. S. / Hu, Xiaoying / Panten, Jasper / Grees, Mareike / Renders, Simon / Thomas, Daniel / Weber, Rebekka / Schulze, Torsten J. / Utikal, Jochen / Umansky, Viktor et al. | 2020
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A novel platinum-based chemotherapeutic inducing immunogenic cell deathKepp, Oliver / Kroemer, Guido et al. | 2020
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Prophylactic and therapeutic antileukemic effects induced by the AAC-11-derived Peptide RT53Habault, Justine / Kaci, Anna / Pasquereau-Kotula, Ewa / Fraser, Claire / Chomienne, Christine / Dombret, Hervé / Braun, Thorsten / Pla, Marika / Poyet, Jean-Luc et al. | 2020
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Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapyGeorganaki, Maria / Ramachandran, Mohanraj / Tuit, Sander / Núñez, Nicolás Gonzalo / Karampatzakis, Alexandros / Fotaki, Grammatiki / van Hooren, Luuk / Huang, Hua / Lugano, Roberta / Ulas, Thomas et al. | 2020
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Integration of intratumoral RASSF10 expression and tumor-associated macrophages into the established clinical indicators better predicts the prognosis of clear cell renal cell carcinoma patientsWang, Chao / Hong, Tianyu / Wang, Yuning / Gan, Sishun / Wang, Qifeng / Li, Jian / Zuo, Li / Cui, Xingang et al. | 2020
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Osteosarcoma and soft-tissue sarcomas with an immune infiltrate express PD-L1: relation to clinical outcome and Th1 pathway activationWunder, Jay S. / Lee, Minji J. / Nam, Junghyun / Lau, Beatrice Y. / Dickson, Brendan C. / Pinnaduwage, Dushanthi / Bull, Shelley B. / Ferguson, Peter C. / Seto, Andrew / Gokgoz, Nalan et al. | 2020
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Cancer immunotherapy based on blocking immune suppression mediated by an immune modulator LAIR-1Xu, Lijun / Wang, Shanlong / Li, Jufeng / Li, Jie / Li, Bingyu et al. | 2020
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Tumor-infiltrating IL-17A+ cells determine favorable prognosis and adjuvant chemotherapeutic response in muscle-invasive bladder cancerWang, Zewei / Zhou, Quan / Zeng, Han / Zhang, Hongyu / Liu, Zhaopei / Huang, Qiuren / Xiong, Ying / Wang, Jiajun / Chang, Yuan / Bai, Qi et al. | 2020
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FLT3LG - a biomarker reflecting clinical responses to the immunogenic cell death inducer oxaliplatinPol, Jonathan G. / Le Naour, Julie / Kroemer, Guido et al. | 2020
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Tumors escape immunosurveillance by overexpressing the proteasome activator PSME3Boulpicante, Mathilde / Darrigrand, Romain / Pierson, Alison / Salgues, Valérie / Rouillon, Marine / Gaudineau, Benoit / Khaled, Mehdi / Cattaneo, Angela / Bachi, Angela / Cascio, Paolo et al. | 2020
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A liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in miceSalomon, Nadja / Vascotto, Fulvia / Selmi, Abderaouf / Vormehr, Mathias / Quinkhardt, Juliane / Bukur, Thomas / Schrörs, Barbara / Löewer, Martin / Diken, Mustafa / Türeci, Özlem et al. | 2020
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Impact of pseudoprogression and treatment beyond progression on outcome in patients with non-small cell lung cancer treated with immune checkpoint inhibitorsWon, Sang Eun / Park, Hyo Jung / Byun, Sangil / Pyo, Junhee / Kim, Jwa Hoon / Choi, Chang-Min / Lee, Jae Cheol / Lee, Dae Ho / Kim, Sang-We / Yoon, Shinkyo et al. | 2020
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Modeling human pediatric and adult gliomas in immunocompetent mice through costimulatory blockadeLan, Xiaoyan / Kedziorek, Dorota A. / Chu, Chengyan / Jablonska, Anna / Li, Shen / Kai, Mihoko / Liang, Yajie / Janowski, Miroslaw / Walczak, Piotr et al. | 2020
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The role of circulating monocytes and JAK inhibition in the infectious-driven inflammatory response of myelofibrosisBarone, Martina / Catani, Lucia / Ricci, Francesca / Romano, Marco / Forte, Dorian / Auteri, Giuseppe / Bartoletti, Daniela / Ottaviani, Emanuela / Tazzari, Pier Luigi / Vianelli, Nicola et al. | 2020
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An unexpected link between immunogenic cell death and inhibition of gene transcriptionHumeau, Juliette / Sauvat, Allan / Kepp, Oliver / Kroemer, Guido et al. | 2020
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Robust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigenLopez-Bujanda, Zoila A. / Chaimowitz, Matthew G. / Armstrong, Todd D. / Foote, Jeremy B. / Emens, Leisha A. / Drake, Charles G. et al. | 2020
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Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockadeGreco, Rita / Qu, Hongjing / Qu, Hui / Theilhaber, Joachim / Shapiro, Gary / Gregory, Richard / Winter, Christopher / Malkova, Natalia / Sun, Frank / Jaworski, Julie et al. | 2020
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Identification and validation of an excellent prognosis subtype of muscle-invasive bladder cancer patients with intratumoral CXCR5+ CD8+ T cell abundanceHuang, Qiuren / Zhou, Quan / Zhang, Hongyu / Liu, Zhaopei / Zeng, Han / Chen, Yifan / Qu, Yang / Xiong, Ying / Wang, Jiajun / Chang, Yuan et al. | 2020
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Immunogenicity and antitumor efficacy of a novel human PD-1 B-cell vaccine (PD1-Vaxx) and combination immunotherapy with dual trastuzumab/pertuzumab-like HER-2 B-cell epitope vaccines (B-Vaxx) in a syngeneic mouse modelKaumaya, Pravin T. P. / Guo, Linlin / Overholser, Jay / Penichet, Manuel L. / Bekaii-Saab, Tanios et al. | 2020
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Association of baseline systemic corticosteroid use with overall survival and time to next treatment in patients receiving immune checkpoint inhibitor therapy in real-world US oncology practice for advanced non-small cell lung cancer, melanoma, or urothelial carcinomaDrakaki, Alexandra / Dhillon, Preet K / Wakelee, Heather / Chui, Stephen Y / Shim, Jinjoo / Kent, Matthew / Degaonkar, Viraj / Hoang, Tien / McNally, Virginia / Luhn, Patricia et al. | 2020
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Heterologous prime-boost immunization co-targeting dual antigens inhibit tumor growth and relapseGuo, Qianqian / Wang, Lizheng / Xu, Ping / Geng, Fei / Guo, Jie / Dong, Ling / Bao, Xin / Zhou, Yi / Feng, Mengfan / Wu, Jiaxin et al. | 2020
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Increased occurrence of status epilepticus in patients with brain metastases and checkpoint inhibitionUrban, Hans / Willems, Laurent M. / Ronellenfitsch, Michael W. / Rosenow, Felix / Steinbach, Joachim P. / Strzelczyk, Adam et al. | 2020
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Intratumoral interleukin-9 delineates a distinct immunogenic class of gastric cancer patients with better prognosis and adjuvant chemotherapeutic responseFang, H. / Li, R. / Gu, Y. / Fei, Yuchao / Jin, Kaifeng / Chen, Yifan / Cao, Yifan / Liu, Xin / Lv, Kunpeng / Wang, Jieti et al. | 2020
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Immune-focused multi-omics analysis of prostate cancer: leukocyte Ig-Like receptors are associated with disease progressionVittrant, Benjamin / Bergeron, Alain / Molina, Oscar Eduardo / Leclercq, Mickael / Légaré, Xavier-Philippe / Hovington, Hélène / Picard, Valérie / Martin-Magniette, Marie-Laure / Livingstone, Julie / Boutros, Paul C. et al. | 2020
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A classification based on tumor budding and immune score for patients with hepatocellular carcinomaWei, Li / Delin, Zhang / Kefei, Yuan / Hong, Wu / Jiwei, Huang / Yange, Zhang et al. | 2020
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Targeting ST2 expressing activated regulatory T cells in Kras-mutant lung cancerKim, Byung-Seok / Clinton, Jelita / Wang, Qing / Chang, Seon Hee et al. | 2020
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PD-L1 is overexpressed on breast cancer stem cells through notch3/mTOR axisMansour, Fatmah A. / Al-Mazrou, Amer / Al-Mohanna, Falah / Al-Alwan, Monther / Ghebeh, Hazem et al. | 2020
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Response and survival of metastatic melanoma patients treated with immune checkpoint inhibition for recurrent disease on adjuvant dendritic cell vaccinationvan Willigen, Wouter W. / Bloemendal, Martine / Boers-Sonderen, Marye J. / de Groot, Jan Willem B. / Koornstra, Rutger H.T. / van der Veldt, Astrid A.M. / Haanen, John B. A. G. / Boudewijns, Steve / Schreibelt, Gerty / Gerritsen, Winald R. et al. | 2020
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Heterogeneity of exhausted T cells in the tumor microenvironment is linked to patient survival following resection in hepatocellular carcinomaLiu, Fangming / Liu, Weiren / Sanin, David E. / Jia, Guangshuai / Tian, Mengxin / Wang, Han / Zhu, Bijun / Lu, Yan / Qiao, Tiankui / Wang, Xiangdong et al. | 2020
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Identification and validation of poor prognosis immunoevasive subtype of muscle-invasive bladder cancer with tumor-infiltrating podoplanin+ cell abundanceZhou, Quan / Wang, Zewei / Zeng, Han / Zhang, Hongyu / Liu, Zhaopei / Huang, Qiuren / Wang, Jiajun / Chang, Yuan / Bai, Qi / Liu, Li et al. | 2020
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B7-H3 inhibits the IFN-γ-dependent cytotoxicity of Vγ9Vδ2 T cells against colon cancer cellsLu, Huimin / Shi, Tongguo / Wang, Mingyuan / Li, Xiaomi / Gu, Yanzheng / Zhang, Xueguang / Zhang, Guangbo / Chen, Weichang et al. | 2020
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Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptideMirando, Adam C. / Patil, Akash / Rafie, Christine I. / Christmas, Brian J. / Pandey, Niranjan B. / Stearns, Vered / Jaffee, Elizabeth M. / Roussos Torres, Evanthia T. / Popel, Aleksander S. et al. | 2020
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Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancerLiang, Tingting / Tong, Weihua / Ma, Siyang / Chang, Pengyu et al. | 2020
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Trial watch: STING agonists in cancer therapyLe Naour, Julie / Zitvogel, Laurence / Galluzzi, Lorenzo / Vacchelli, Erika / Kroemer, Guido et al. | 2020
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Trial watch: IDO inhibitors in cancer therapyLe Naour, Julie / Galluzzi, Lorenzo / Zitvogel, Laurence / Kroemer, Guido / Vacchelli, Erika et al. | 2020
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Tumor mutational burden is not predictive of cytotoxic chemotherapy responseNikanjam, Mina / Riviere, Paul / Goodman, Aaron / Barkauskas, Donald A. / Frampton, Garrett / Kurzrock, Razelle et al. | 2020
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SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4Carmona-Rodríguez, Lorena / Martínez-Rey, Diego / Mira, Emilia / Mañes, Santos et al. | 2020
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Adjuvant MUC vaccination with tecemotide after resection of colorectal liver metastases: a randomized, double-blind, placebo-controlled, multicenter AIO phase II trial (LICC)Schimanski, Carl Christoph / Kasper, Stefan / Hegewisch-Becker, Susanna / Schröder, Jan / Overkamp, Friedrich / Kullmann, Frank / Bechstein, Wolf Otto / Vöhringer, Matthias / Öllinger, Robert / Lordick, Florian et al. | 2020
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Identification of novel autoantibodies based on the protein chip encoded by cancer-driving genes in detection of esophageal squamous cell carcinomaSun, Guiying / Ye, Hua / Wang, Xiao / Cheng, Lin / Ren, Pengfei / Shi, Jianxiang / Dai, Liping / Wang, Peng / Zhang, Jianying et al. | 2020
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Cancer testis antigens in myelodysplastic syndromes revisited: a targeted RNA-seq approachHurtado López, Ana María / Chen-Liang, Tzu Hua / Zurdo, María / Carrillo-Tornel, Salvador / Panadero, Joaquín / Salido, Eduardo José / Beltrán, Victor / Muiña, Begoña / Amigo, MariLuz / Navarro-Villamor, Noelia et al. | 2020
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Efficacy and biomarker analysis of CD133-directed CAR T cells in advanced hepatocellular carcinoma: a single-arm, open-label, phase II trialDai, Hanren / Tong, Chuan / Shi, Daiwei / Chen, Meixia / Guo, Yelei / Chen, Deyun / Han, Xiao / Wang, Hua / Wang, Yao / Shen, Pingping et al. | 2020
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Skin inflammatory response and efficacy of anti-epidermal growth factor receptor therapy in metastatic colorectal cancer (CUTACETUX)Tougeron, David / Emambux, Sheik / Favot, Laure / Lecomte, Thierry / Wierzbicka-Hainaut, Ewa / Samimi, Mahtab / Frouin, Eric / Azzopardi, Nicolas / Chevrier, Jocelyn / Serres, Laura et al. | 2020
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Calreticulin arms NK cells against leukemiaFucikova, Jitka / Kline, Justin P. / Galluzzi, Lorenzo / Spisek, Radek et al. | 2020
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Deciphering the transcriptomic landscape of tumor-infiltrating CD8 lymphocytes in B16 melanoma tumors with single-cell RNA-SeqCarmona, Santiago J. / Siddiqui, Imran / Bilous, Mariia / Held, Werner / Gfeller, David et al. | 2020
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Identification and characterization of M6903, an antagonistic anti–TIM-3 monoclonal antibodyZhang, Dong / Jiang, Feng / Zaynagetdinov, Rinat / Huang, Hui / Sood, Vanita D. / Wang, Hong / Zhao, Xinyan / Jenkins, Molly H. / Ji, Qingyong / Wang, Youbin et al. | 2020
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Development of CAR-T cell therapy for B-ALL using a point-of-care approachde Macedo Abdo, Luiza / Barros, Luciana Rodrigues Carvalho / Saldanha Viegas, Mariana / Vieira Codeço Marques, Luisa / de Sousa Ferreira, Priscila / Chicaybam, Leonardo / Bonamino, Martín Hernán et al. | 2020
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IL-17 suppresses the therapeutic activity of cancer vaccines through the inhibition of CD8+ T-cell responsesDadaglio, Gilles / Fayolle, Catherine / Oberkampf, Marine / Tang, Alexandre / Rudilla, Francesc / Couillin, Isabelle / Torheim, Eirik A. / Rosenbaum, Pierre / Leclerc, Claude et al. | 2020
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The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccinesWeis-Banke, Stine Emilie / Hübbe, Mie Linder / Holmström, Morten Orebo / Jørgensen, Mia Aaboe / Bendtsen, Simone Kloch / Martinenaite, Evelina / Carretta, Marco / Svane, Inge Marie / Ødum, Niels / Pedersen, Ayako Wakatsuki et al. | 2020
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Regulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanismsDas, Mrinmoy / Stephen-Victor, Emmanuel / Bayry, Jagadeesh et al. | 2020
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Trial watch : the gut microbiota as a tool to boost the clinical efficacy of anticancer immunotherapyDaillère, Romain / Derosa, Lisa / Bonvalet, Mélodie / Segata, Nicola / Routy, Bertrand / Gariboldi, Manuela / Budinská, Eva / De Vries, I. Jolanda M. / Naccarati, Alessio Gordon / Zitvogel, Valérie et al. | 2020
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IL15 synergizes with radiotherapy to reprogram the tumor immune contexture through a dendritic cell connectionPilones, Karsten A. / Charpentier, Maud / Garcia-Martinez, Elena / Demaria, Sandra et al. | 2020
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Specific immune landscapes and immune checkpoint expressions in histotypes and molecular subtypes of sarcomaDufresne, A. / Lesluyes, T. / Ménétrier-Caux, C. / Brahmi, M. / Darbo, E. / Toulmonde, M. / Italiano, A. / Mir, O. / Le Cesne, A. / Le Guellec, S. et al. | 2020
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RNA-electroporated T cells for cancer immunotherapyPohl-Guimarães, Fernanda / Hoang-Minh, Lan B. / Mitchell, Duane A. et al. | 2020
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Anti-tumor immunity influences cancer cell reliance upon ATG7Arensman, Michael D. / Yang, Xiaoran S. / Zhong, Wenyan / Bisulco, Stephanie / Upeslacis, Erik / Rosfjord, Edward C. / Deng, Shibing / Abraham, Robert T. / Eng, Christina H. et al. | 2020
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Recombinant viruses delivering the necroptosis mediator MLKL induce a potent antitumor immunity in miceVan Hoecke, Lien / Riederer, Stephanie / Saelens, Xavier / Sutter, Gerd / Rojas, Juan J. et al. | 2020
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Immune surveillance activation after neoadjuvant therapy for esophageal adenocarcinoma and complete responseKotsafti, Andromachi / Scarpa, Melania / Cavallin, Francesco / Fassan, Matteo / Salmaso, Roberta / Porzionato, Andrea / Saadeh, Luca / Cagol, Matteo / Alfieri, Rita / Castoro, Carlo et al. | 2020
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Metastasis immune-based scores predict patient survivalMlecnik, Bernhard / Bindea, Gabriela / Van den Eynde, Marc / Galon, Jérôme et al. | 2020
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Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspectiveHuang, Xing / Zhang, Gang / Bai, Xueli / Liang, Tingbo et al. | 2020
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No time to die: the consensus immunoscore for predicting survival and response to chemotherapy of locally advanced colon cancer patients in a multicenter international studyAscierto, Paolo A. / Marincola, Francesco M. / Fox, Bernard A. / Galon, Jérôme et al. | 2020
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Small-molecule PD-L1 inhibitor BMS1166 abrogates the function of PD-L1 by blocking its ER exportChen, Fang-Fang / Li, Zheng / Ma, Dawei / Yu, Qiang et al. | 2020
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Usefulness and robustness of Immunoscore for personalized management of cancer patientsMarliot, Florence / Pagès, Franck / Galon, Jérôme et al. | 2020
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Intratumoral CD103+CD4+ T cell infiltration defines immunoevasive contexture and poor clinical outcomes in gastric cancer patientsGu, Yun / Chen, Yifan / Jin, Kaifeng / Cao, Yifan / Liu, Xin / Lv, Kunpeng / He, Xudong / Lin, Chao / Liu, Hao / Li, He et al. | 2020
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PD-L1 expression in the microenvironment and the response to checkpoint inhibitors in head and neck squamous cell carcinomaEvrard, D. / Hourseau, M. / Couvelard, A. / Paradis, V. / Gauthier, H. / Raymond, E. / Halimi, C. / Barry, B. / Faivre, S. et al. | 2020
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Epstein–Barr virus-positive diffuse large B-cell lymphoma features disrupted antigen capture/presentation and hijacked T-cell suppressionJiang, Xiang-Nan / Yu, Bao-Hua / Yan, Wan-Hui / Lee, Jimmy / Zhou, Xiao-Yan / Li, Xiao-Qiu et al. | 2020
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PT-112 induces immunogenic cell death and synergizes with immune checkpoint blockers in mouse tumor modelsYamazaki, Takahiro / Buqué, Aitziber / Ames, Tyler D. / Galluzzi, Lorenzo et al. | 2020
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PD-1 blockade in neoadjuvant setting of DNA mismatch repair-deficient/microsatellite instability-high colorectal cancerLiu, Ding-Xin / Li, Dan-Dan / He, Wan / Ke, Chuan-Feng / Jiang, Wu / Tang, Jing-Hua / Kong, Ling-Heng / Li, Yuan / Sui, Qiao-Qi / Xiao, Bin-Yi et al. | 2020
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HLA class-I and class-II restricted neoantigen loads predict overall survival in breast cancerRen, Yingxue / Cherukuri, Yesesri / Wickland, Daniel P. / Sarangi, Vivekananda / Tian, Shulan / Carter, Jodi M. / Mansfield, Aaron S. / Block, Matthew S. / Sherman, Mark E. / Knutson, Keith L. et al. | 2020
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Liver metastases and the efficacy of the PD-1 or PD-L1 inhibitors in cancer: a meta-analysis of randomized controlled trialsLi, Shan / Sun, Shanquan / Xiang, Hui / Yang, Jing / Peng, Minyong / Gao, Qing et al. | 2020
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Tumor-associated tertiary lymphoid structure predicts postoperative outcomes in patients with primary gastrointestinal stromal tumorsLin, Qiaowei / Tao, Ping / Wang, Jiongyuan / Ma, Lijie / Jiang, Quan / Li, Jinglei / Zhang, Ge / Liu, Ju / Zhang, Yong / Hou, Yingyong et al. | 2020
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Results of the phase I open label clinical trial SAKK 06/14 assessing safety of intravesical instillation of VPM1002BC, a recombinant mycobacterium Bacillus Calmette Guérin (BCG), in patients with non-muscle invasive bladder cancer and previous failure of conventional BCG therapyRentsch, Cyrill A. / Bosshard, Piet / Mayor, Grégoire / Rieken, Malte / Püschel, Heike / Wirth, Grégory / Cathomas, Richard / Parzmair, Gerald P. / Grode, Leander / Eisele, Bernd et al. | 2020
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CD19-targeting fusion protein combined with PD1 antibody enhances anti-tumor immunity in mouse modelsLv, Zhuangwei / Zhang, Ping / Li, Dandan / Qin, Mengting / Nie, Longzhu / Wang, Xiaoqian / Ai, Li / Feng, Zhaozu / Odhiambo, Woodvine Otieno / Ma, Yunfeng et al. | 2020
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Dose dependence of treatment-related adverse events for immune checkpoint inhibitor therapies: a model-based meta-analysisShulgin, Boris / Kosinsky, Yuri / Omelchenko, Andrey / Chu, Lulu / Mugundu, Ganesh / Aksenov, Sergey / Pimentel, Rodrigo / DeYulia, Garrett / Kim, Geoffrey / Peskov, Kirill et al. | 2020
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Hypoxia increases mutational load of breast cancer cells through frameshift mutationsHassan Venkatesh, Goutham / Bravo, Pamela / Shaaban Moustafa Elsayed, Walid / Amirtharaj, Francis / Wojtas, Bartosz / Abou Khouzam, Raefa / Hussein Nawafleh, Husam / Mallya, Sandeep / Satyamoorthy, Kapaettu / Dessen, Philippe et al. | 2020
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Tumor stem cells fuse with monocytes to form highly invasive tumor-hybrid cellsAguirre, Luis Augusto / Montalbán-Hernández, Karla / Avendaño-Ortiz, José / Marín, Elvira / Lozano, Roberto / Toledano, Víctor / Sánchez-Maroto, Laura / Terrón, Verónica / Valentín, Jaime / Pulido, Elisa et al. | 2020
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Clinical and immune responses to anti-CD3 x anti-EGFR bispecific antibody armed activated T cells (EGFR BATs) in pancreatic cancer patientsLum, Lawrence G. / Thakur, Archana / Choi, Minsig / Deol, Abhinav / Kondadasula, Vidya / Schalk, Dana / Fields, Kristie / Dufrense, Melissa / Philip, Philip / Dyson, Gregory et al. | 2020
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Myeloid deletion of phosphoinositide-dependent kinase-1 enhances NK cell-mediated antitumor immunity by mediating macrophage polarizationHe, Yuexi / Du, Juan / Dong, Zhongjun et al. | 2020
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The role of trogocytosis in immune surveillance of Hodgkin lymphomaZeng, Qun / Schwarz, Herbert et al. | 2020
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Expression signature, prognosis value, and immune characteristics of Siglec-15 identified by pan-cancer analysisLi, Baihui / Zhang, Bailu / Wang, Xuezhou / Zeng, Ziqing / Huang, Ziqi / Zhang, Lin / Wei, Feng / Ren, Xiubao / Yang, Lili et al. | 2020
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Identification of a costimulatory molecule-based signature for predicting prognosis risk and immunotherapy response in patients with lung adenocarcinomaZhang, Chaoqi / Zhang, Zhihui / Sun, Nan / Zhang, Zhen / Zhang, Guochao / Wang, Feng / Luo, Yuejun / Che, Yun / He, Jie et al. | 2020
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Adapter chimeric antigen receptor (AdCAR)-engineered NK-92 cells: an off-the-shelf cellular therapeutic for universal tumor targetingGrote, Stefan / Mittelstaet, Joerg / Baden, Caroline / Chan, Kenneth Chun-Ho / Seitz, Christian / Schlegel, Patrick / Kaiser, Andrew / Handgretinger, Rupert / Schleicher, Sabine et al. | 2020
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Resveratrol exerts antitumor effects by downregulating CD8+CD122+ Tregs in murine hepatocellular carcinomaZhang, Qunfang / Huang, Haiding / Zheng, Fang / Liu, Huazhen / Qiu, Feifei / Chen, Yuchao / Liang, Chun-Ling / Dai, Zhenhua et al. | 2020
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Reduction of CD11b+ myeloid suppressive cells augments anti-neuroblastoma immune response induced by the anti-GD2 antibody ch14.18/CHOSiebert, Nikolai / Zumpe, Maxi / von Lojewski, Leon / Troschke-Meurer, Sascha / Marx, Madlen / Lode, Holger N. et al. | 2020
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Anti-cancer immunotherapy using cancer-derived multiple epitope-peptides cocktail vaccination clinical studies in patients with refractory/persistent disease of uterine cervical cancer and ovarian cancer [phase 2]Takeuchi, Satoshi / Kagabu, Masahiro / Shoji, Tadahiro / Nitta, Yukari / Sugiyama, Toru / Sato, Junya / Nakamura, Yusuke et al. | 2020
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Angiotensin-converting enzyme (ACE) inhibitor prescription affects non-small-cell lung cancer (NSCLC) patients response to PD-1/PD-L1 immune checkpoint blockersMedjebar, Soleine / Truntzer, Caroline / Perrichet, Anaïs / Limagne, Emeric / Fumet, Jean-David / Richard, Corentin / Elkrief, Arielle / Routy, Bertrand / Rébé, Cédric / Ghiringhelli, François et al. | 2020
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Soluble forms of PD-L1 and PD-1 as prognostic and predictive markers of sunitinib efficacy in patients with metastatic clear cell renal cell carcinomaMontemagno, Christopher / Hagege, Anais / Borchiellini, Delphine / Thamphya, Brice / Rastoin, Olivia / Ambrosetti, Damien / Iovanna, Juan / Rioux-Leclercq, Nathalie / Porta, Camillio / Negrier, Sylvie et al. | 2020
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Establishing a model system for evaluating CAR T cell therapy using dogs with spontaneous diffuse large B cell lymphomaPanjwani, M. Kazim / Atherton, Matthew J. / MaloneyHuss, Martha A. / Haran, Kumudhini P. / Xiong, Ailian / Gupta, Minnal / Kulikovsaya, Irina / Lacey, Simon F. / Mason, Nicola J. et al. | 2020
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Comedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancerHamy, Anne-Sophie / Derosa, Lisa / Valdelièvre, Constance / Yonekura, Satoru / Opolon, Paule / Priour, Maël / Guerin, Julien / Pierga, Jean-Yves / Asselain, Bernard / De Croze, Diane et al. | 2020
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Preclinical evaluation of an affinity-enhanced MAGE-A4-specific T-cell receptor for adoptive T-cell therapySanderson, Joseph P / Crowley, Darragh J / Wiedermann, Guy E / Quinn, Laura L / Crossland, Katherine L / Tunbridge, Helen M / Cornforth, Terri V / Barnes, Christopher S / Ahmed, Tina / Howe, Karen et al. | 2020
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Identification of a CD8+ T-cell response to a predicted neoantigen in malignant mesotheliomaSneddon, Sophie / Rive, Craig M. / Ma, Shaokang / Dick, Ian M. / Allcock, Richard J. N. / Brown, Scott D. / Holt, Robert A. / Watson, Mark / Leary, Shay / Lee, Y. C. Gary et al. | 2020
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Secreted calreticulin mutants subvert anticancer immunosurveillanceLiu, Peng / Zhao, Liwei / Kroemer, Guido / Kepp, Oliver et al. | 2020
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Durable tumor regression in highly refractory metastatic KIT/PDGFRA wild-type GIST following treatment with nivolumabSchroeder, Brett A. / Kohli, Karan / O’Malley, Ryan B. / Kim, Theresa S. / Jones, Robin L. / Pierce, Robert H. / Pollack, Seth M. et al. | 2020
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Deep neural network classification based on somatic mutations potentially predicts clinical benefit of immune checkpoint blockade in lung adenocarcinomaPeng, Jie / Zou, Dan / Gong, Wuxing / Kang, Shuai / Han, Lijie et al. | 2020
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Enhanced expression of CD39 and CD73 on T cells in the regulation of anti-tumor immune responsesShevchenko, Ivan / Mathes, Andreas / Groth, Christopher / Karakhanova, Svetlana / Müller, Verena / Utikal, Jochen / Werner, Jens / Bazhin, Alexandr V. / Umansky, Viktor et al. | 2020
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ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistanceOrme, Jacob J. / Jazieh, Khalid A. / Xie, Tiancheng / Harrington, Susan / Liu, Xin / Ball, Matthew / Madden, Benjamin / Charlesworth, M. Cristine / Azam, Tariq U. / Lucien, Fabrice et al. | 2020
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Prognostic value of CD73 expression in resected colorectal cancer liver metastasisMessaoudi, Nouredin / Cousineau, Isabelle / Arslanian, Elizabeth / Henault, David / Stephen, David / Vandenbroucke-Menu, Franck / Dagenais, Michel / Létourneau, Richard / Plasse, Marylène / Roy, André et al. | 2020
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CD200 and CD200R1 are differentially expressed and have differential prognostic roles in non-small cell lung cancerYoshimura, Katsuhiro / Suzuki, Yuzo / Inoue, Yusuke / Tsuchiya, Kazuo / Karayama, Masato / Iwashita, Yuji / Kahyo, Tomoaki / Kawase, Akikazu / Tanahashi, Masayuki / Ogawa, Hiroshi et al. | 2020
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The prognostic role of NK cells and their ligands in squamous cell carcinoma of the head and neck: a systematic review and meta-analysisBisheshar, Sangeeta K. / De Ruiter, Emma J. / Devriese, Lot A. / Willems, Stefan M. et al. | 2020
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Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustionBalkhi, Mumtaz Y. et al. | 2020
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Exosomal communication by metastatic osteosarcoma cells modulates alveolar macrophages to an M2 tumor-promoting phenotype and inhibits tumoricidal functionsWolf-Dennen, Kerri / Gordon, Nancy / Kleinerman, Eugenie S. et al. | 2020
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Heterogeneity of immune microenvironment in ovarian cancer and its clinical significance: a retrospective studyGao, Yue / Chen, Lingxi / Cai, Guangyao / Xiong, Xiaoming / Wu, Yuan / Ma, Ding / Li, Shuai Cheng / Gao, Qinglei et al. | 2020
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The ambiguous role of FPR1 in immunity and inflammationVacchelli, Erika / Le Naour, Julie / Kroemer, Guido et al. | 2020
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COVID-19: a challenge for oncology servicesRouty, Bertrand / Derosa, Lisa / Zitvogel, Laurence / Kroemer, Guido et al. | 2020
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Trial watch: TLR3 agonists in cancer therapyLe Naour, Julie / Galluzzi, Lorenzo / Zitvogel, Laurence / Kroemer, Guido / Vacchelli, Erika et al. | 2020
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Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitorsDaillère, Romain / Routy, Bertrand / Goubet, Anne-Gaëlle / Cogdill, Alexandria / Ferrere, Gladys / Alves-Costa Silva, Carolina / Fluckiger, Aurélie / Ly, Pierre / Haddad, Yacine / Pizzato, Eugenie et al. | 2020
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The consensus Immunoscore in phase 3 clinical trial (N0147) and impact on patient management decisionsLanzi, Anastasia / Sinicrope, F. A. / Benson, A. B. / Galon, Jérôme et al. | 2020
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Primary and metastatic breast tumors cross-talk to influence immunotherapy responsesOliver, Amanda J / Keam, Simon P / von Scheidt, Bianca / Zanker, Damien J / Harrison, Aaron J / Tantalo, Daniela GM / Darcy, Phillip K / Kershaw, Michael H / Slaney, Clare Y et al. | 2020
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Immune responses during COVID-19 infectionMelenotte, Cléa / Silvin, Aymeric / Goubet, Anne-Gaëlle / Lahmar, Imran / Dubuisson, Agathe / Zumla, Alimuddin / Raoult, Didier / Merad, Mansouria / Gachot, Bertrand / Hénon, Clémence et al. | 2020
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Firing up the cold tumors by targeting Vps34Janji, Bassam / Hasmim, Meriem / Parpal, Santiago / Berchem, Guy / Noman, Muhammad Zaeem et al. | 2020
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Generation of GM-CSF-producing antigen-presenting cells that induce a cytotoxic T cell-mediated antitumor responseMashima, Hiroaki / Zhang, Rong / Kobayashi, Tsuyoshi / Hagiya, Yuichiro / Tsukamoto, Hirotake / Liu, Tianyi / Iwama, Tatsuaki / Yamamoto, Masateru / Lin, Chiahsuan / Nakatsuka, Ryusuke et al. | 2020
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Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancerJimenez-Rodriguez, Rosa M. / Patil, Sujata / Keshinro, Ajaratu / Shia, Jinru / Vakiani, Efsevia / Stadler, Zsofia / Segal, Neil H. / Yaeger, Rona / Konishi, Tsuyoshi / Shimada, Yoshifumi et al. | 2020
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A Phase 1b Study Evaluating the Safety, Tolerability, and Immunogenicity of CMB305, a Lentiviral-Based Prime-Boost Vaccine Regimen, in Patients with Locally Advanced, Relapsed, or Metastatic Cancer Expressing NY-ESO-1Somaiah, Neeta / Chawla, Sant P. / Block, Matthew S. / Morris, John C. / Do, Khanh / Kim, Joseph W. / Druta, Mihaela / Sankhala, Kamalesh K. / Hwu, Patrick / Jones, Robin L. et al. | 2020
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Cancer Risks in Solid Organ Transplant Recipients: Results from a Comprehensive Analysis of 72 Cohort StudiesHuo, Zhenyu / Li, Caichen / Xu, Xin / Ge, Fan / Wang, Runchen / Wen, Yaokai / Peng, Haoxin / Wu, Xiangrong / Liang, Hengrui / Peng, Guilin et al. | 2020