The role of NKT cells in gastrointestinal cancers (Unbekannt)
Freier Zugriff
- Neue Suche nach: Burks, Julian
- Neue Suche nach: Olkhanud, Purevdorj B.
- Neue Suche nach: Berzofsky, Jay A.
- Neue Suche nach: Burks, Julian
- Neue Suche nach: Olkhanud, Purevdorj B.
- Neue Suche nach: Berzofsky, Jay A.
In:
OncoImmunology
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11
, 1
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2022
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ISSN:
- Aufsatz (Zeitschrift) / Elektronische Ressource
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Titel:The role of NKT cells in gastrointestinal cancers
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Beteiligte:
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Erschienen in:OncoImmunology ; 11, 1
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Verlag:
- Neue Suche nach: Taylor & Francis
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Erscheinungsdatum:31.12.2022
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ISSN:
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DOI:
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Medientyp:Aufsatz (Zeitschrift)
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Format:Elektronische Ressource
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Sprache:Unbekannt
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Schlagwörter:
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Datenquelle:
Inhaltsverzeichnis – Band 11, Ausgabe 1
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Cell-directed aptamer therapeutic targeting for cancers including those within the central nervous systemWei, Jun / Song, Renduo / Sabbagh, Aria / Marisetty, Anantha / Shukla, Neal / Fang, Dexing / Najem, Hinda / Ott, Martina / Long, James / Zhai, Lijie et al. | 2022
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Clostridium butyricum therapy restores the decreased efficacy of immune checkpoint blockade in lung cancer patients receiving proton pump inhibitorsTomita, Yusuke / Goto, Yoshihiko / Sakata, Shinya / Imamura, Kosuke / Minemura, Ayaka / Oka, Kentaro / Hayashi, Atsushi / Jodai, Takayuki / Akaike, Kimitaka / Anai, Moriyasu et al. | 2022
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Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activationHe, Teng / Hao, Zhixing / Lin, Mingjie / Xin, Zhongwei / Chen, Yongyuan / Ouyang, Wei / Yang, Qi / Chen, Xiaoke / Zhou, Hui / Zhang, Wanying et al. | 2022
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Oncolytic adenovirus with MUC16-BiTE shows enhanced antitumor immune response by reversing the tumor microenvironment in PDX model of ovarian cancerWang, Qiuman / Ma, Xinyue / Wu, Huan / Zhao, Chen / Chen, Jingying / Li, Rongrong / Yan, Shi / Li, Yingwei / Zhang, Qing / Song, Kun et al. | 2022
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Enhancement of tumor immunogenicity by the introduction of non- proteinogenic amino acid azetidine-2-carboxylic acidLi, Siyu / Wang, Shiqing / Tian, Baorui / Li, Na / Chen, Yanan / Liu, Yanhua / Su, Weijun / Fan, Yan / Piao, Yongjun / Li, Jia et al. | 2022
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One cisplatin dose provides durable stimulation of anti-tumor immunity and alleviates anti-PD-1 resistance in an intraductal model for triple-negative breast cancerSteenbrugge, Jonas / Bellemans, Julie / Vander Elst, Niels / Demeyere, Kristel / De Vliegher, Josephine / Perera, Timothy / De Wever, Olivier / Van Den Broeck, Wim / De Spiegelaere, Ward / Sanders, Niek N. et al. | 2022
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A T-cell engaging bispecific antibody with a tumor-selective bivalent folate receptor alpha binding arm for the treatment of ovarian cancerAvanzino, Brian C. / Prabhakar, Kirthana / Dalvi, Pranjali / Hartstein, Sharon / Kehm, Hannes / Balasubramani, Aarti / Boudreau, Andrew A. / Buelow, Ben / Chang, Karen / Davison, Laura M. et al. | 2022
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Immune response to SARS-CoV-2 mRNA vaccination and booster dose in patients with multiple myeloma and monoclonal gammopathies: impact of Omicron variant on the humoral responseStorti, Paola / Marchica, Valentina / Vescovini, Rosanna / Franceschi, Valentina / Russo, Luca / Notarfranchi, Laura / Raimondi, Vincenzo / Toscani, Denise / Burroughs Garcia, Jessica / Costa, Federica et al. | 2022
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Therapeutic Targeting of MYC in Head and Neck Squamous Cell CarcinomaLiu, Shuo / Qin, Zhen / Mao, Yaqing / Zhang, Wenbo / Wang, Yujia / Jia, Lingfei / Peng, Xin et al. | 2022
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Combined targeting of soluble latent TGF-ß and a solid tumor-associated antigen with adapter CAR T cellsWerchau, Niels / Kotter, Bettina / Criado-Moronati, Elvira / Gosselink, Andre / Cordes, Nicole / Lock, Dominik / Lennartz, Simon / Kolbe, Carolin / Winter, Nora / Teppert, Karin et al. | 2022
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Mesenchymal stem cells shuttling miR-503 via extracellular vesicles enhance glioma immune escapeWang, Xiao-Song / Yu, Xiao-Jun / Wei, Kang / Wang, Shan-Xi / Liu, Qi-Kun / Wang, Ying-Guang / Li, Han / Huang, Cheng et al. | 2022
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Generation and functional characterization of a multigene-modified NK101 cell line exerting diverse mechanisms of antitumor actionHwang, Injung / Jin, Hyun Tak / Kang, Moon Cheol / Kim, Tae Yoon / Sung, Young Chul / Kim, Sae Won et al. | 2022
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Mice transgenic for human CTLA4-CD28 fusion gene show proliferation and transformation of ATLL-like and AITL-like T cellsLee, Gyu Jin / Jun, Yukyung / Jeon, Yoon Kyung / Lee, Daekee / Lee, Sanghyuk / Kim, Jaesang et al. | 2022
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Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patientsLipp, Jesse J. / Wang, Limei / Yang, Haitang / Yao, Feng / Harrer, Nathalie / Müller, Stefan / Berezowska, Sabina / Dorn, Patrick / Marti, Thomas M. / Schmid, Ralph A. et al. | 2022
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Potential of Mycobacterium tuberculosis chorismate mutase (Rv1885c) as a novel TLR4-mediated adjuvant for dendritic cell-based cancer immunotherapyJeong, Hyein / Lee, So-Young / Seo, Hyejun / Kim, Dong Hyun / Lee, Duhyung / Kim, Bum-Joon et al. | 2022
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Identification of a unique tumor cell subset employing myeloid transcriptional circuits to create an immunomodulatory microenvironment in glioblastomaYang, Kaidi / Shi, Yu / Luo, Min / Mao, Min / Zhang, Xiaoning / Chen, Cong / Liu, Yuqi / He, Zhicheng / Liu, Qing / Wang, Wenying et al. | 2022
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Coupling the immunomodulatory properties of the HDAC6 inhibitor ACY241 with Oxaliplatin promotes robust anti-tumor response in non-small cell lung cancerBag, Arup / Schultz, Andrew / Bhimani, Saloni / Stringfield, Olya / Dominguez, William / Mo, Qianxing / Cen, Ling / Adeegbe, Dennis et al. | 2022
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Correction| 2022
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Immune suppressive microenvironment in brain metastatic non-small cell lung cancer: comprehensive immune microenvironment profiling of brain metastases versus paired primary lung tumors (GASTO 1060)Li, Meichen / Hou, Xue / Sai, Ke / Wu, Lihong / Chen, Jing / Zhang, Baishen / Wang, Na / Wu, Lijia / Zheng, Hongbo / Zhang, Jiao et al. | 2022
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A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitorsHackett, Justin B. / Glassbrook, James E. / Muñiz, Maria C. / Bross, Madeline / Fielder, Abigail / Dyson, Gregory / Movahhedin, Nasrin / McCasland, Jennifer / McCarthy-Leo, Claire / Gibson, Heather M. et al. | 2022
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A nanoparticle-based tour de force for enhancing immunogenic cell death elicited by photodynamic therapyKepp, Oliver / Kroemer, Guido et al. | 2022
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Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regressionKudling, Tatiana V. / Clubb, James H.A. / Quixabeira, Dafne C.A. / Santos, Joao M. / Havunen, Riikka / Kononov, Alexander / Heiniö, Camilla / Cervera-Carrascon, Victor / Pakola, Santeri / Basnet, Saru et al. | 2022
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Synergistic effect of combining sunitinib with a peptide-based vaccine in cancer treatment after microenvironment remodelingMougel, Alice / Méjean, Fanny / Tran, Thi / Adimi, Yasmine / Galy-Fauroux, Isabelle / Kaboré, Christelle / Mercier, Erwan / Urquia, Pauline / Terme, Magali / Tartour, Eric et al. | 2022
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An adjuvant-containing cDC1-targeted recombinant fusion vaccine conveys strong protection against murine melanoma growth and metastasisArabpour, Mohammad / Paul, Sanchari / Grauers Wiktorin, Hanna / Kaya, Mustafa / Kiffin, Roberta / Lycke, Nils / Hellstrand, Kristoffer / Martner, Anna et al. | 2022
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CXCL10-armed oncolytic adenovirus promotes tumor-infiltrating T-cell chemotaxis to enhance anti-PD-1 therapyLi, Xiaofei / Lu, Mingjie / Yuan, Manman / Ye, Jing / Zhang, Wei / Xu, Lingyan / Wu, Xiaohan / Hui, Bingqing / Yang, Yuchen / Wei, Bin et al. | 2022
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Immunosuppressive tumor microenvironment modulation by chemotherapies and targeted therapies to enhance immunotherapy effectivenessBarnestein, Robby / Galland, Loïck / Kalfeist, Laura / Ghiringhelli, François / Ladoire, Sylvain / Limagne, Emeric et al. | 2022
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Human allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligandsChoi, Haeyoun / Lee, Yunkyung / Park, Soon A / Lee, Ji Hyeon / Park, Junseong / Park, Jang Hyun / Lee, Heung Kyu / Kim, Tai-Gyu / Jeun, Sin-Soo / Ahn, Stephen et al. | 2022
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Personalized therapy with peptide-based neoantigen vaccine (EVX-01) including a novel adjuvant, CAF®09b, in patients with metastatic melanomaMørk, Sofie Kirial / Kadivar, Mohammad / Bol, Kalijn Fredrike / Draghi, Arianna / Westergaard, Marie Christine Wulff / Skadborg, Signe Koggersbøl / Overgaard, Nana / Sørensen, Anders Bundgård / Rasmussen, Ida Svahn / Andreasen, Lars Vibe et al. | 2022
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LCVM infection generates tumor antigen-specific immunity and inhibits growth of nonviral tumorsJacqueline, Camille / Dracz, Matthew / Xue, Jia / Binder, Robert J. / Minden, Jonathan / Finn, Olivera et al. | 2022
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Stimulatory and inhibitory activity of STING ligands on tumor-reactive human gamma/delta T cellsSerrano, Ruben / Lettau, Marcus / Zarobkiewicz, Michal / Wesch, Daniela / Peters, Christian / Kabelitz, Dieter et al. | 2022
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An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulationMuik, Alexander / Altintas, Isil / Gieseke, Friederike / Schoedel, Kristina B / Burm, Saskia M / Toker, Aras / Salcedo, Theodora W. / Verzijl, Dennis / Eisel, David / Grunwitz, Christian et al. | 2022
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What’s next in cancer immunotherapy? - The promise and challenges of neoantigen vaccinationRedwood, Alec J. / Dick, Ian M. / Creaney, Jenette / Robinson, Bruce W. S. et al. | 2022
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STING agonist cGAMP enhances anti-tumor activity of CAR-NK cells against pancreatic cancerDa, Yanyan / Liu, Yuxia / Hu, Yuan / Liu, Wenzeng / Ma, Junpeng / Lu, Nan / Zhang, Chengsheng / Zhang, Cai et al. | 2022
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Combination with Toll-like receptor 4 (TLR4) agonist reverses GITR agonism mediated M2 polarization of macrophage in Hepatocellular carcinomaPan, Caixu / Wu, Qinchuan / Wang, Shuai / Mei, Zhibin / Zhang, Lele / Gao, Xingxing / Qian, Junjie / Xu, Zhentian / Zhang, Ke / Su, Rong et al. | 2022
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MHC class II molecules on pancreatic cancer cells indicate a potential for neo-antigen-based immunotherapyBaleeiro, Renato B. / Bouwens, Christian J. / Liu, Peng / Di Gioia, Carmela / Dunmall, Louisa S. Chard / Nagano, Ai / Gangeswaran, Rathistevy / Chelala, Claude / Kocher, Hemant M. / Lemoine, Nicholas R. et al. | 2022
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Urinary T cells are detected in patients with immune checkpoint inhibitor-associated immune nephritis that are clonotypically identical to kidney T cell infiltratesSingh, Shailbala / Clemente, Leticia C. / Parra, Edwin R. / Tchakarov, Amanda / Yang, Chao / Li, Yisheng / Long, James P. / Yee, Cassian / Lin, Jamie S. et al. | 2022
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A novel membrane-bound interleukin-2 promotes NK-92 cell persistence and anti-tumor activityXiong, Qi / Zhang, Hantao / Ji, Xuanle / Zhang, Yong / Shi, Gang / Dai, Lei / Cheng, Fuyi / Wang, Huiling / Luo, Jieyan / Xu, Jia et al. | 2022
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A newly discovered PD-L1 B-cell epitope peptide vaccine (PDL1-Vaxx) exhibits potent immune responses and effective anti-tumor immunity in multiple syngeneic mice models and (synergizes) in combination with a dual HER-2 B-cell vaccine (B-Vaxx)Guo, Linlin / Overholser, Jay / Darby, Heather / Ede, Nicholas J. / Kaumaya, Pravin T.P et al. | 2022
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Ecto-calreticulin expression in multiple myeloma correlates with a failed anti-tumoral immune response and bad prognosisSerrano Del Valle, Alfonso / Beltrán-Visiedo, Manuel / de Poo-Rodríguez, Victoria / Jiménez-Alduán, Nelia / Azaceta, Gemma / Díez, Rosana / Martínez-Lázaro, Beatriz / Izquierdo, Isabel / Palomera, Luis / Naval, Javier et al. | 2022
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Enhancing anti-tumor efficacy and immune memory by combining 3p-GPC-3 siRNA treatment with PD-1 blockade in hepatocellular carcinomaShao, Liwei / Yu, Xin / Han, Qiuju / Zhang, Xinke / Lu, Nan / Zhang, Cai et al. | 2022
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CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor developmentMelese, Etienne S. / Franks, Elizabeth / Cederberg, Rachel A. / Harbourne, Bryant T. / Shi, Rocky / Wadsworth, Brennan J. / Collier, Jenna L. / Halvorsen, Elizabeth C. / Johnson, Fraser / Luu, Jennifer et al. | 2022
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Association between immune-related adverse event timing and treatment outcomesHsiehchen, David / Naqash, Abdul Rafeh / Espinoza, Magdalena / Von Itzstein, Mitchell S. / Cortellini, Alessio / Ricciuti, Biagio / Owen, Dwight H. / Laharwal, Mehak / Toi, Yukihiro / Burke, Michael et al. | 2022
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A first-in-class, non-invasive, immunodynamic biomarker approach for precision immuno-oncologySprooten, Jenny / Coosemans, An / Garg, Abhishek D. et al. | 2022
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Dissecting the mechanism of cytokine release induced by T-cell engagers highlights the contribution of neutrophilsLeclercq, Gabrielle / Servera, Llucia Alberti / Danilin, Sabrina / Challier, John / Steinhoff, Nathalie / Bossen, Claudia / Odermatt, Alex / Nicolini, Valeria / Umaña, Pablo / Klein, Christian et al. | 2022
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Single-cell analysis by mass cytometry reveals CD19 CAR T cell spatiotemporal plasticity in patientsGoldberg, Lior / Haas, Eric R. / Vyas, Vibhuti / Urak, Ryan / Forman, Stephen J. / Wang, Xiuli et al. | 2022
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Serial changes in liquid biopsy-derived variant allele frequency predict immune checkpoint inhibitor responsiveness in the pan-cancer settingKato, Shumei / Li, Bing / Adashek, Jacob J. / Cha, Seong Won / Bianchi-Frias, Daniella / Qian, Dajun / Kim, Lisa / so, Tiffany W / Mitchell, Marcus / Kamei, Naoki et al. | 2022
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Synapse topology and downmodulation events determine the functional outcome of anti-CD19 T cell-redirecting strategiesRamírez-Fernández, Ángel / Aguilar-Sopeña, Óscar / Díez-Alonso, Laura / Segura-Tudela, Alejandro / Domínguez-Alonso, Carmen / Roda-Navarro, Pedro / Álvarez-Vallina, Luis / Blanco, Belén et al. | 2022
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Evaluation of radio-immunotherapy sequence on immunological responses and clinical outcomes in patients with melanoma brain metastases (ELEKTRA)Hassel, Jessica C. / Schank, Timo E. / Smetak, Heiko / Mühlbauer, Jasmin / Salzmann, Martin / Machiraju, Devayani / Menzer, Christian / Lang, Kristin / König, Laila / Haefner, Matthias F. et al. | 2022
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Neoadjuvant chemoradiation alters the immune microenvironment in pancreatic ductal adenocarcinomaGartrell, Robyn D. / Enzler, Thomas / Kim, Pan S. / Fullerton, Benjamin T. / Fazlollahi, Ladan / Chen, Andrew X. / Minns, Hanna E. / Perni, Subha / Weisberg, Stuart P. / Rizk, Emanuelle M. et al. | 2022
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Novel approach to identify putative Epstein–Barr–virus microRNAs regulating host cell genes with relevance in tumor biology and immunologyJasinski-Bergner, Simon / Blümke, Juliane / Bauer, Marcus / Skiebe, Saskia Luise / Mandelboim, Ofer / Wickenhauser, Claudia / Seliger, Barbara et al. | 2022
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Novel strategies for the mitigation of cytokine release syndrome induced by T cell engaging therapies with a focus on the use of kinase inhibitorsLeclercq, Gabrielle / Steinhoff, Nathalie / Haegel, Hélène / De Marco, Donata / Bacac, Marina / Klein, Christian et al. | 2022
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Trial watch: Dendritic cell (DC)-based immunotherapy for cancerLaureano, Raquel S / Sprooten, Jenny / Vanmeerbeerk, Isaure / Borras, Daniel M / Govaerts, Jannes / Naulaerts, Stefan / Berneman, Zwi N / Beuselinck, Benoit / Bol, Kalijn F / Borst, Jannie et al. | 2022
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Targeting 3D chromosomal architecture at the RANK loci to suppress myeloma-driven osteoclastogenesisThümmler, Katja / Williams, Mark TS / Kitson, Susan / Sood, Shatakshi / Akbar, Moeed / Cole, John J / Hunter, Ewan / Soutar, Richard / Goodyear, Carl S et al. | 2022
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Tbc1d10c is a selective, constitutive suppressor of the CD8 T-cell anti-tumor responseCohen, Adrienne O. / Woo, Seung-Hyun / Zhang, Junya / Cho, Jiyoon / Ruiz, Marlon E. / Gong, Jianli / Du, Rong / Yarygina, Olga / Jafri, Danya Z. / Bachelor, Michael A. et al. | 2022
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Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibodyWeaver, Jessica D. / Stack, Edward C. / Buggé, Joshua A. / Hu, Changyun / McGrath, Lara / Mueller, Amy / Wong, Masie / Klebanov, Boris / Rahman, Tanzila / Kaufman, Rosemary et al. | 2022
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Chemokine switch regulated by TGF-β1 in cancer-associated fibroblast subsets determines the efficacy of chemo-immunotherapyVienot, Angélique / Pallandre, Jean-René / Renaude, Elodie / Viot, Julien / Bouard, Adeline / Spehner, Laurie / Kroemer, Marie / Abdeljaoued, Syrine / van der Woning, Bas / de Haard, Hans et al. | 2022
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BCL11B depletion induces the development of highly cytotoxic innate T cells out of IL-15 stimulated peripheral blood αβ CD8+ T cellsForkel, Hannes / Grabarczyk, Piotr / Depke, Maren / Troschke-Meurer, Sascha / Simm, Stefan / Hammer, Elke / Michalik, Stephan / Hentschker, Christian / Corleis, Björn / Loyal, Lucie et al. | 2022
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Spatial immune heterogeneity of hypoxia-induced exhausted features in high-grade gliomaKim, A-Reum / Choi, Seong Jin / Park, Junsik / Kwon, Minsuk / Chowdhury, Tamrin / Yu, Hyeon Jong / Kim, Sojin / Kang, Ho / Kim, Kyung-Min / Park, Su-Hyung et al. | 2022
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MUC1-C integrates type II interferon and chromatin remodeling pathways in immunosuppression of prostate cancerHagiwara, Masayuki / Fushimi, Atsushi / Bhattacharya, Atrayee / Yamashita, Nami / Morimoto, Yoshihiro / Oya, Mototsugu / Withers, Henry G. / Hu, Qiang / Liu, Tao / Liu, Song et al. | 2022
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Vasculogenic mimicry structures in melanoma support the recruitment of monocytesTan, Lih Y. / Cockshell, Michaelia P. / Moore, Eli / Myo Min, Kay K. / Ortiz, Michael / Johan, M. Zahied / Ebert, Brenton / Ruszkiewicz, Andrew / Brown, Michael P. / Ebert, Lisa M. et al. | 2022
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Neutrophil extracellular traps induce tumor metastasis through dual effects on cancer and endothelial cellsJiang, Ze-Zhou / Peng, Zhi-Peng / Liu, Xing-Chen / Guo, Hao-Fan / Zhou, Meng-Meng / Jiang, Da / Ning, Wan-Ru / Huang, Yu-Fan / Zheng, Limin / Wu, Yan et al. | 2022
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A loss-of-function polymorphism in ATG16L1 compromises therapeutic outcome in head and neck carcinoma patientsLe Naour, Julie / Sztupinszki, Zsofia / Carbonnier, Vincent / Casiraghi, Odile / Marty, Virginie / Galluzzi, Lorenzo / Szallasi, Zoltan / Kroemer, Guido / Vacchelli, Erika et al. | 2022
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OX40 and 4-1BB delineate distinct immune profiles in sarcomaMelake, MJ / Smith, HG / Mansfield, D / Davies, E / Dillon, MT / Wilkins, AC / Patin, EC / Pedersen, M / Buus, R / Melcher, AA et al. | 2022
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Biglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cellsSubbarayan, Karthikeyan / Massa, Chiara / Leisz, Sandra / Steven, André / Bethmann, Daniel / Biehl, Katharina / Wickenhauser, Claudia / Seliger, Barbara et al. | 2022
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Intratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effectPrasit, Kef K / Ferrer-Font, Laura / Burn, Olivia K / Anderson, Regan J / Compton, Benjamin J / Schmidt, Alfonso J / Mayer, Johannes U / Chen, Chun-Jen J / Dasyam, Nathaniel / Ritchie, David S et al. | 2022
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Immunoreactivity against fibroblast growth factor 8 in alveolar rhabdomyosarcoma patients and its involvement in tumor aggressivenessPoli, Elena / Barbon, Vanessa / Lucchetta, Silvia / Cattelan, Manuela / Santoro, Luisa / Zin, Angelica / Milano, Giuseppe Maria / Zanetti, Ilaria / Bisogno, Gianni / Bonvini, Paolo et al. | 2022
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CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumorsSalewski, Inken / Henne, Julia / Engster, Leonie / Krone, Paula / Schneider, Bjoern / Redwanz, Caterina / Lemcke, Heiko / Henze, Larissa / Junghanss, Christian / Maletzki, Claudia et al. | 2022
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Helicobacter pylori serology is associated with worse overall survival in patients with melanoma treated with immune checkpoint inhibitorsTonneau, Marion / Nolin-Lapalme, Alexis / Kazandjian, Suzanne / Auclin, Edouard / Panasci, Justin / Benlaifaoui, Myriam / Ponce, Mayra / Al-Saleh, Afnan / Belkaid, Wiam / Naimi, Sabrine et al. | 2022
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The MICA-NKG2D axis in clear cell renal cell carcinoma bolsters MICA as target in immuno-oncologySecchiari, Florencia / Nuñez, Sol Yanel / Sierra, Jessica Mariel / Ziblat, Andrea / Regge, María Victoria / Raffo Iraolagoitia, Ximena Lucía / Rovegno, Agustín / Ameri, Carlos / Secin, Fernando Pablo / Richards, Nicolás et al. | 2022
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CAR-T Engager proteins optimize anti-CD19 CAR-T cell therapies for lymphomaSu, Lihe / Wu, Lan / Lobb, Roy R. / Rennert, Paul D. / Ambrose, Christine et al. | 2022
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Immune targeting of three independent suppressive pathways (TIGIT, PD-L1, TGFβ) provides significant antitumor efficacy in immune checkpoint resistant modelsFranks, S. Elizabeth / Fabian, Kellsye P. / Santiago-Sánchez, Ginette / Wolfson, Benjamin / Hodge, James W. et al. | 2022
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The efficacy and safety of first-line treatment in cisplatin-ineligible advanced upper tract urothelial carcinoma patients: a comparison of PD-1 inhibitor and carboplatin plus gemcitabine chemotherapyHuang, Jiwei / Su, Ruopeng / Chen, Zeyu / Jiang, Shuai / Chen, Minfeng / Yuan, Yichu / Hu, Hailong / Fu, Changde / Huang, Zhiyang / Wang, Zhenyu et al. | 2022
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Comprehensive evaluation of the tumor immune microenvironment and its dynamic changes in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy: From the phase II ADORE studyCho, Hyungwoo / Kim, Jeong Eun / Hong, Yong Sang / Kim, Sun Young / Kim, Jihun / Ryu, Yeon-Mi / Kim, Sang-Yeob / Kim, Tae Won et al. | 2022
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Selective depletion of polymorphonuclear myeloid derived suppressor cells in tumor beds with near infrared photoimmunotherapy enhances host immune responseKato, Takuya / Fukushima, Hiroshi / Furusawa, Aki / Okada, Ryuhei / Wakiyama, Hiroaki / Furumoto, Hideyuki / Okuyama, Shuhei / Takao, Seiichiro / Choyke, Peter L. / Kobayashi, Hisataka et al. | 2022
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Impaired CXCL12 signaling contributes to resistance of pancreatic cancer subpopulations to T cell-mediated cytotoxicityLin, Yuan-Na / Schmidt, Marcel O. / Sharif, Ghada M. / Vietsch, Eveline E. / Kiliti, Amber J. / Barefoot, Megan E. / Riegel, Anna T. / Wellstein, Anton et al. | 2022
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T-SIGn tumor reengineering therapy and CAR T cells synergize in combination therapy to clear human lung tumor xenografts and lung metastases in NSG miceSonzogni, Olmo / Zak, Daniel E. / Sasso, Maria Stella / Lear, Rochelle / Muntzer, Alice / Zonca, Manuela / West, Katy / Champion, Brian R. / Rottman, James B. et al. | 2022
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CD4+ T cells in classical Hodgkin lymphoma express exhaustion associated transcription factors TOX and TOX2Veldman, Johanna / Rodrigues Plaça, Jessica / Chong, Lauren / Terpstra, Miente Martijn / Mastik, Mirjam / van Kempen, Léon C. / Kok, Klaas / Aoki, Tomohiro / Steidl, Christian / van den Berg, Anke et al. | 2022
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IFN-γ activates the tumor cell-intrinsic STING pathway through the induction of DNA damage and cytosolic dsDNA formationXiong, Hui / Xi, Yu / Yuan, Zhiwei / Wang, Boyu / Hu, Shaojie / Fang, Can / Cai, Yixin / Fu, Xiangning / Li, Lequn et al. | 2022
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Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockadeLiu, Jiao / Kang, Rui / Kroemer, Guido / Tang, Daolin et al. | 2022
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The endoplasmic reticulum chaperone BiP: a target for immunogenic cell death inducers?Kepp, Oliver / Bezu, Lucillia / Kroemer, Guido et al. | 2022
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Homologous recombination repair deficient prostate cancer represents an immunologically distinct subtypevan Wilpe, Sandra / Simnica, Donjetë / Slootbeek, Peter / van Ee, Thomas / Pamidimarri Naga, Samhita / Gorris, Mark A. J. / van der Woude, Lieke L. / Sultan, Shabaz / Koornstra, Rutger H. T. / van Oort, Inge M. et al. | 2022
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Enriched circulating and tumor-resident TGF-β+ regulatory B cells in patients with melanoma promote FOXP3+ TregsHarris, Robert J / Willsmore, Zena / Laddach, Roman / Crescioli, Silvia / Chauhan, Jitesh / Cheung, Anthony / Black, Anna / Geh, Jenny L. C. / MacKenzie Ross, Alastair D / Healy, Ciaran et al. | 2022
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Schweinfurthin induces ICD without ER stress and caspase activationZhang, Ruoheng / Neighbors, J.D. / Schell, T.D. / Hohl, R.J. et al. | 2022
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CCL22-based peptide vaccines induce anti-cancer immunity by modulating tumor microenvironmentLecoq, Inés / Kopp, Katharina L. / Chapellier, Marion / Mantas, Panagiotis / Martinenaite, Evelina / Perez-Penco, Maria / Rønn Olsen, Lars / Zocca, Mai-Britt / Wakatsuki Pedersen, Ayako / Andersen, Mads Hald et al. | 2022
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IRE1α overexpression in malignant cells limits tumor progression by inducing an anti-cancer immune responseMartinez-Turtos, Adriana / Paul, Rachel / Grima-Reyes, Manuel / Issaoui, Hussein / Krug, Adrien / Mhaidly, Rana / Bossowski, Jozef P. / Chiche, Johanna / Marchetti, Sandrine / Verhoeyen, Els et al. | 2022
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Type I interferon induces cancer stem cells-mediated chemotherapy resistanceDe Martino, Mara / Vanpouille-Box, Claire et al. | 2022
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AAV-mediated gene transfer of a checkpoint inhibitor in combination with HER2-targeted CAR-NK cells as experimental therapy for glioblastomaStrecker, M.I. / Wlotzka, K. / Strassheimer, F. / Roller, B. / Ludmirski, G. / König, S. / Röder, J. / Opitz, C. / Alekseeva, T. / Reul, J. et al. | 2022
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Fibroblasts and macrophages cooperate to create a pro-tumorigenic and immune resistant environment via activation of TGF-β/IL-6 pathway in neuroblastomaLouault, Kevin / Porras, Tania / Lee, Meng-Hua / Muthugounder, Sakunthala / Kennedy, Rebekah J. / Blavier, Laurence / Sarte, Emily / Fernandez, G. Esteban / Yang, Fusheng / Pawel, Bruce R. et al. | 2022
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Uric acid accumulation in DNA-damaged tumor cells induces NKG2D ligand expression and antitumor immunity by activating TGF-β-activated kinase 1Wang, Jingxiang / Liu, Kai / Xiao, Tianxiang / Liu, Penggang / Prinz, Richard A. / Xu, Xiulong et al. | 2022
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Tertiary lymphoid structures and their association to immune phenotypes and circulatory IL2 levels in pancreatic ductal adenocarcinomaAhmed, Azaz / Köhler, Sophia / Klotz, Rosa / Giese, Nathalia / Hackert, Thilo / Springfeld, Christoph / Zörnig, Inka / Jäger, Dirk / Halama, Niels et al. | 2022
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Fc-based Duokines: dual-acting costimulatory molecules comprising TNFSF ligands in the single-chain format fused to a heterodimerizing Fc (scDk-Fc)Aschmoneit, Nadine / Kocher, Katharina / Siegemund, Martin / Lutz, Martina S. / Kühl, Lennart / Seifert, Oliver / Kontermann, Roland E. et al. | 2022
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Beneficial autoimmunity and maladaptive inflammation shape epidemiological links between cancer and immune-inflammatory diseasesPol, Jonathan / Paillet, Juliette / Plantureux, Céleste / Kroemer, Guido et al. | 2022
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Immunostimulatory effects of vitamin B5 improve anticancer immunotherapyBourgin, Melanie / Kepp, Oliver / Kroemer, Guido et al. | 2022
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Tumor-associated macrophages promote intratumoral conversion of conventional CD4+ T cells into regulatory T cells via PD-1 signallingKos, Kevin / Salvagno, Camilla / Wellenstein, Max D. / Aslam, Muhammad A. / Meijer, Denize A. / Hau, Cheei-Sing / Vrijland, Kim / Kaldenbach, Daphne / Raeven, Elisabeth A.M. / Schmittnaegel, Martina et al. | 2022
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Overcoming T cell dysfunction in acidic pH to enhance adoptive T cell transfer immunotherapyNavarro, Flor / Casares, Noelia / Martín-Otal, Celia / Lasarte-Cía, Aritz / Gorraiz, Marta / Sarrión, Patricia / Llopiz, Diana / Reparaz, David / Varo, Nerea / Rodriguez-Madoz, Juan Roberto et al. | 2022
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Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in miceNath, Pulak R. / Pal-Nath, Dipasmita / Kaur, Sukhbir / Gangaplara, Arunkumar / Meyer, Thomas J. / Cam, Margaret C / Roberts, David D. et al. | 2022
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Nivolumab plus ipilimumab in metastatic uveal melanoma: a real-life, retrospective cohort of 47 patientsSalaün, Hélène / de Koning, Leanne / Saint-Ghislain, Mathilde / Servois, Vincent / Ramtohul, Toulsie / Garcia, Agathe / Matet, Alexandre / Cassoux, Nathalie / Mariani, Pascale / Piperno-Neumann, Sophie et al. | 2022
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Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activationLopez-Pelaez, Marta / Young, Lucy / Vazquez-Chantada, Mercedes / Nelson, Nadine / Durant, Steve / Wilkinson, Robert W. / Poon, Edmund / Gaspar, Miguel / Valge-Archer, Viia / Smith, Paul et al. | 2022
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Is ferroptosis immunogenic? The devil is in the details!Kepp, Oliver / Kroemer, Guido et al. | 2022
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Influencing tumor-associated macrophages in malignant melanoma with monoclonal antibodiesAdams, Rebecca / Osborn, Gabriel / Mukhia, Bipashna / Laddach, Roman / Willsmore, Zena / Chenoweth, Alicia / Geh, Jenny L C / MacKenzie Ross, Alastair D / Healy, Ciaran / Barber, Linda et al. | 2022
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SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade responseIbáñez-Molero, Sofía / van Vliet, Alex / Pozniak, Joanna / Hummelink, Karlijn / Terry, Alexandra M. / Monkhorst, Kim / Sanders, Joyce / Hofland, Ingrid / Landeloos, Ewout / Van Herck, Yannick et al. | 2022
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Neoadjuvant PD-1 blockade plus chemotherapy induces a high pathological complete response rate and anti-tumor immune subsets in clinical stage III gastric cancerTang, Xiaohuan / Li, Mengyuan / Wu, Xiaolong / Guo, Ting / Zhang, Li / Tang, Lei / Jia, Fangzhou / Hu, Ying / Zhang, Yan / Xing, Xiaofang et al. | 2022
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A role for EMT in CD73 regulation in breast cancerHasmim, Meriem / Berchem, Guy / Janji, Bassam et al. | 2022