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Medical in vivo applications like catheters or permanent implants do have blood contact with the body-strange material resulting in reactions and disturbances in the blood circulation. Blood compatible materials can be used in contact with circulating blood and are able to keep coagulation processes under control at its interface with normal blood. A way to make bodystrange materials blood compatible is to coat a blood compatible layer on the surface. With the right density the intermolecular interaction between the molecules results in stretching of the grafted polymers and a brush coating arises. We have applied brush coatings successfully onto substrates with a good anchoring mechanism resulting in stable brushes in contact with blood. Thrombin analyse as well as the platelets aggregation suggest that the coating improves the blood compatibility.