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Cyclodextrin-based nano- and microgels are multifunctional polymeric colloidal networks which adsorb easily and homogeneously onto surfaces, where they should be bound physically. The embedded cyclodextrin container consists of six, seven or eight D-glucose units which form cyclic oligomers with a hydrophilic outer surface. The hydrophobic interior cavity has a diameter of 5-8 Angstroem and enables the formation of complexes with suitable hydrophobic guest molecules. The incorporation of cyclodextrins into the polymer network promotes improved uptake and release properties of micro- and nanogels and especially of low molecular weight guest molecules. A potential application of cyclodextrins is the complexation of antimicrobial agents. Chlorhexidine is an antiseptic and bacteriostatic agent that shows activity against enveloped viruses. The uptake of chlorhexidine in cyclodextrin microgels based on poly(methylmethacrylate) (PMMA) is described and the application of chlorhexidine-loaded microgels on textiles and other surfaces is investigated. Furthermore, biological tests of the efficiencies of chlorhexidine microgels and of the textiles are performed.