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Approaches for calculating an appropriate safety-stock level are supposed to ensure a designated service level with preferably low inventory. This paper analyses established mathematical methods for calculating safety-stock. Initially, these methods will be described and their specifics pointed out. With the aid of an extensive simulation study the performance of the methods is then mapped in regards to the resulting service and safety-stock level against the background of different articles with variant logistical behaviour. Overall, the simulation study shows, among the various methods of safety stock calculation no superior approach. Depending on the particular conditions different approaches each have their respective strengthen. An overview of the gained results of the presented simulation study is provided. It shows the application areas divided by the main influencing factors (variation of demand and replenishment time) and the methods which should be preferably used for each area. Using this overview in practice the areas low, medium and high should be determined according to the variation coefficients of the replenishment time and the demand rate calculated here.