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This paper aims to present the simulation of technological process of components made by plastic injection using a computer within a orthotic device for human knee. Also, the aim of the work is to improve the final product quality and operating properties in different types of design and minimize material requirements for different anthropometric data quality in optimal conditions. The orthotic device addresses to people with walking disabilities, and aims to rehabilitate and ameliorate the pain caused by osteoarthritis disease. For the geometric modeling of components in order to obtain virtual mathematical model study we used ProEngineer application, which allows a detailed design and a high accurate technical approach. The model was imported into the Moldex3D application, being integrated within a XYZ coordinate system. To simulate the injection process we used only the component from the upper part of orthotic device. This paper presents advanced modeling elements, geometric mesh model into an advanced form of nodes and elements, plastic injection process analysis settings. It highlights the tensions, deformations and displacements in these parts during the injection process.