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This report includes a comprehensive manual of the computer program PROSA which illustrates the handling and functioning of PROSA. The manual PROSA 4.0 desribes the PC Version of PROSA including its Program Moduls. The PROSA program package is a statistical tool to decide on the basis of statistical assumptions whether in a given sequence of material balance periods a loss of material might have occurred. The evaluation of the material balance data is based on statistical test procedures. In the present PROSA Version 4.0 the three tests CUMUF test, PAGE's test and GEMUF test are applied to a sequence of material balances. PROSA Version 4.0 supports a real sequential evaluation. That means, PROSA is not only able to evaluate a series of MUF values sequentially after the campaign has finished, but also real sequentially during the campaign. PROSA Version 4.0 is a menu-guided computer program. Data input can be performed either by diskette or by key-enter. Result output is primarily an information whether or not an alarm is indicated. This information can be displayed either numerically or graphically. Therefore, a comfortable either numerically or graphically. Therefore, a comfortable graphical output utility is attached to PROSA 4.0. PROSA Version 4.0 is written in FORTRAN 77 and the program moduls are compiled and linked with the Ryan Mc-Farland Compiler. The PROSA Graphical Utility uses the PLOT88 Library of Plotworks, Inc..