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The major limitation of peripheral nerve repair has been the matching of specific axon-to-axon connections to re-establish correct communication channels within the peripheral nervous system following the transection of a nerve. The purpose of this project is the development of a microelectronic silicon chip neuroprosthesis for nerve repair at the axon level that would enable specific axon-to-axon connection. This would require the development of an implantable silicon chip (1 by 1 millimeter in size) with a matrix of addressable axon tubes such that severed axons could regenerate through the tubes. Several of these chips stacked in sequence can act as a micro-switchboard to identify and control regeneration axon-to-axon communication. By electronically connecting the correct proximal and distal ends of the microchip axon tubes, input and output information in the repaired peripheral nerve can be directed to the proper channels, thus effecting a nervous system repair at the axon level.(TIB-TIB:08.88)