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Clostridium difficile drug pipeline: challenges in discovery and development of new agents
Online Contents | 2015| -
Water-Soluble and Cleavable Quercetin-Amino Acid Conjugates as Safe Modulators for P-Glycoprotein-Based Multidrug Resistance
British Library Online Contents | 2014| -
Optimization of Sphingosine-1-phosphate-1 Receptor Agonists: Effects of Acidic, Basic, and Zwitterionic Chemotypes on Pharmacokinetic and Pharmacodynamic Profiles
British Library Online Contents | 2014| -
In Vitro and in Vivo Evaluation of Water-Soluble Iminophosphorane Ruthenium(II) Compounds. A Potential Chemotherapeutic Agent for Triple Negative Breast Cancer
British Library Online Contents | 2014| -
Structure-Guided Development of Deoxycytidine Kinase Inhibitors with Nanomolar Affinity and Improved Metabolic Stability
British Library Online Contents | 2014| -
Absolute Quantitative ^1H NMR Spectroscopy for Compound Purity Determination
British Library Online Contents | 2014| -
Noncovalent Fluorescent Probes of Human Immuno- and Constitutive Proteasomes
British Library Online Contents | 2014| -
Targeting Nucleus DNA with a Cyclometalated Dipyridophenazineruthenium(II) Complex
British Library Online Contents | 2014| -
Nonpeptide Small Molecule Agonist and Antagonist Original Leads for Neuropeptide FF1 and FF2 Receptors
British Library Online Contents | 2014| -
Discovery, Synthesis, and Optimization of Antimalarial 4(1H)-Quinolone-3-Diarylethers
British Library Online Contents | 2014| -
Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?
British Library Online Contents | 2014| -
Synthesis and Evaluation of Three Structurally Related ^1^8F-Labeled Orvinols of Different Intrinsic Activities: 6-O-[^1^8F] Fluoroethyl-diprenorphine ([^1^8F]FDPN), 6-O-[^1^8F]Fluoroethyl-buprenorphine ([^1^8F]FBPN), and 6-O-[^1^8F]Fluoroethyl-phenethyl-orvinol ([^1^8F]FPEO)
British Library Online Contents | 2014| -
Structure Guided Design and Kinetic Analysis of Highly Potent Benzimidazole Inhibitors Targeting the PDE delta Prenyl Binding Site
British Library Online Contents | 2014| -
Molecular Systems Pharmacology: Isoelectric Focusing Signature of Protein Kinase C delta Provides an Integrated Measure of Its Modulation in Response to Ligands
British Library Online Contents | 2014| -
Cinnamic Anilides as New Mitochondrial Permeability Transition Pore Inhibitors Endowed with Ischemia-Reperfusion Injury Protective Effect in Vivo
British Library Online Contents | 2014| -
Discovery, Optimization, and Biological Evaluation of 5-(2-Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists
British Library Online Contents | 2014| -
Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors
British Library Online Contents | 2014| -
Synthesis and Biological Evaluation of N,N'-Squaramides with High in Vivo Efficacy and Low Toxicity: Toward a Low-Cost Drug against Chagas Disease
British Library Online Contents | 2014| -
Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 2'-Fluoro-3'-(substituted pyridinyl)-7-deschloroepibatidine Analogues
British Library Online Contents | 2014| -
Design, Synthesis, and Biological Activity of Pyridopyrimidine Scaffolds as Novel PI3K/mTOR Dual Inhibitors
British Library Online Contents | 2014| -
Discovery of (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations
British Library Online Contents | 2014| -
Efficacious Inhaled PDE4 Inhibitors with Low Emetic Potential and Long Duration of Action for the Treatment of COPD
British Library Online Contents | 2014| -
New Pyrazolobenzothiazine Derivatives as Hepatitis C Virus NS5B Polymerase Palm Site I Inhibitors
British Library Online Contents | 2014| -
Structure-Activity Relationship Studies and Discovery of a Potent Transient Receptor Potential Vanilloid (TRPV1) Antagonist 4-[3-Chloro-5-[(1S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxamide (V116517) as a Clinical Candidate for Pain Management
British Library Online Contents | 2014| -
Diarylthiazole: An Antimycobacterial Scaffold Potentially Targeting PrrB-PrrA Two-Component System
British Library Online Contents | 2014| -
Functional Probes of Drug-Receptor Interactions Implicated by Structural Studies: Cys-Loop Receptors Provides a Fertile Testing Ground
British Library Online Contents | 2014| -
Exploring the Determinants of Trace Amine-Associated Receptor 1's Functional Selectivity for the Stereosiomers of Amphetamine and Methamphetamine
British Library Online Contents | 2014| -
Structure-Based Design of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors
British Library Online Contents | 2014| -
Molecular Simulations with Solvent Competition Quantify Water Displaceability and Provide Accurate Interaction Maps of Protein Binding Sites
British Library Online Contents | 2014| -
Discovery of N-Substituted Oseltamivir Derivatives as Potent and Selective Inhibitors of H5N1 Influenza Neuraminidase
British Library Online Contents | 2014| -
Phenyl Substituted 4-Hydroxypyridazin-3-(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease
British Library Online Contents | 2014| -
Thioaryl Naphthylmethanone Oxime Ether Analogs as Novel Anticancer Agents
British Library Online Contents | 2014| -
In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs
British Library Online Contents | 2014|
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