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$$L_p$$-Support vector machines for uplift modeling
Freier ZugriffOnline Contents | 2017|Schlagwörter: Control group, Support vector machine -
-Support vector machines for uplift modeling
Freier ZugriffSpringer Verlag | 2017|Schlagwörter: Control group, Support vector machine -
Study on the stress evolution law of surrounding rock and cooperative control technology in coal seam group mining
Freier ZugriffDOAJ | 2024|Schlagwörter: coal seam group, roadway support, collaborative control technology of “unloading-rotating-fixing” -
Emergency Service Provision Using a Novel Hybrid SOM-Spiral STC Model for Group Decision Support under Dynamic Uncertainty
Freier ZugriffDOAJ | 2019|Schlagwörter: group decision support, autonomous robot control -
Recovery of platinum group metals from spent automotive converters and their conversion into efficient recyclable nanocatalysts
Freier ZugriffSpringer Verlag | 2023|Schlagwörter: Platinum group metals (PGM), Titanium (IV) dioxide support, Atmospheric Protection/Air Quality Control/Air Pollution, Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution -
Pro-active meeting assistants: attention please!
Freier ZugriffSpringer Verlag | 2007|Schlagwörter: Group Support System, Control, Robotics, Mechatronics -
An Exploration of Information Systems Adoption
Freier ZugriffTools and Skills as Cultural Artefacts—The Case of a Management Information SystemSpringer Verlag | 2007|Schlagwörter: Support Group, Management Control -
Major scientific and technological innovation achievements and practices of CHN Shendong Coal Group
Freier ZugriffDOAJ | 2023|Schlagwörter: chn shendong coal group, ten million tons of mines group, centralized control center of hundred million tons mining area, pure water hydraulic support, “three phases and three circles” ecological control model -
Cultivating Recalcitrance in Information Systems Research
Freier ZugriffSpringer Verlag | 2001|Schlagwörter: Group Decision Support System, Systems Theory, Control -
Method and Technology of Green Coal Mining
Freier ZugriffTIBKAT | 2023|Schlagwörter: ground control, asymmetric control, surrounding rock control, main roadway group, cooperative control, support, surrounding rock control technology -
Probability, Stochastic Processes and Optimization
Freier ZugriffTIBKAT | 2023|Schlagwörter: relative group entropy, optimal control, full support for replication of results -
Structure, Function and Regulation of the Hsp90 Machinery
Freier ZugriffDOAJ | 2013|Schlagwörter: Hsp90 works together with a large group of cofactors, Hop/Sti1 is a member of the large group of TPR co-chaperones. They contain a specialized conserved TPR-clamp domain, belong to this group. The TPR-containing PPIases contain a PPIase domain, Aha1 plays a critical role in the inherited misfolding disease cystic fibrosis (CF) through participating in the quality control pathway of the cystic fibrosis transmembrane conductance regulator (CFTR). Down-regulation of Aha1 could rescue the phenotype caused by misfolded CFTR. [73] Recent research highlighted the function of Aha1 in the progression of the Hsp90 cycle. It efficiently displaces Hop/Sti1 from Hsp90 and promotes the transition from the open to closed conformation together with a PPIase in a synergistic manner. [74] Pp5/Ppt1 is a protein phosphatase which is involved in this cycle through regulating the phosphorylation states of Cdc37. It associates with Hsp90 through its N-terminal TPR domain. Binding to Hsp90 results in the abrogation of the intrinsic inhibition of Pp5/Ppt1. [75] Pp5/Ppt1 specifically dephosphorylates Hsp90 and Cdc37 in Hsp90 complexes. [76], and methylation tightly control the function of Hsp90 and thus influence the maturation of client proteins. [93] Phosphorylation Phosphorylation is the most frequently detected posttranslational modification of Hsp90. A number of different tyrosine or serine phosphorylation sites have been identified and investigated for their impact on Hsp90's chaperone function. [94] For example, p300 was reported to be the acetyltransferase and HDAC6 acts as a deacetylase which removes the acetyl group from the protein. [105], Hsp90 fails to support the activation of the client protein. [108] Nitrosylation S-nitrosylation is a reversible covalent modification of reactive cysteine thiols in proteins by nitric oxide (NO). [109], such as the location of the client-binding sites on Hsp90. Current evidence suggests that binding sites could be localized in each of the domains of Hsp90. [8] Another intriguing question unsolved so far is how Hsp90 recognizes its clients. Hsp90 clients belong to different families and do not share common sequences or structural motifs. Although some regions were identified which are important for the recognition of certain group of clients
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