Antitumor Polycyclic Acridines. 8. Synthesis and Telomerase-Inhibitory Activity of Methylated Pentacyclic Acridinium Salts (Englisch)
- Neue Suche nach: Heald, R. A.
- Neue Suche nach: Modi, C.
- Neue Suche nach: Cookson, J. C.
- Neue Suche nach: Hutchinson, I.
- Neue Suche nach: Laughton, C. A.
- Neue Suche nach: Gowan, S. M.
- Neue Suche nach: Kelland, L. R.
- Neue Suche nach: Stevens, M. F. G.
- Neue Suche nach: Heald, R. A.
- Neue Suche nach: Modi, C.
- Neue Suche nach: Cookson, J. C.
- Neue Suche nach: Hutchinson, I.
- Neue Suche nach: Laughton, C. A.
- Neue Suche nach: Gowan, S. M.
- Neue Suche nach: Kelland, L. R.
- Neue Suche nach: Stevens, M. F. G.
In:
JOURNAL OF MEDICINAL CHEMISTRY
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45
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590-597
;
2002
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ISSN:
- Aufsatz (Zeitschrift) / Print
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Titel:Antitumor Polycyclic Acridines. 8. Synthesis and Telomerase-Inhibitory Activity of Methylated Pentacyclic Acridinium Salts
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Beteiligte:Heald, R. A. ( Autor:in ) / Modi, C. ( Autor:in ) / Cookson, J. C. ( Autor:in ) / Hutchinson, I. ( Autor:in ) / Laughton, C. A. ( Autor:in ) / Gowan, S. M. ( Autor:in ) / Kelland, L. R. ( Autor:in ) / Stevens, M. F. G. ( Autor:in )
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Erschienen in:JOURNAL OF MEDICINAL CHEMISTRY ; 45 ; 590-597
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Verlag:
- Neue Suche nach: ACS AMERICAN CHEMICAL SOCIETY
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Erscheinungsdatum:01.01.2002
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Format / Umfang:8 pages
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ISSN:
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Medientyp:Aufsatz (Zeitschrift)
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Format:Print
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Sprache:Englisch
- Neue Suche nach: 615
- Weitere Informationen zu Dewey Decimal Classification
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Klassifikation:
DDC: 615 -
Datenquelle:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Inhaltsverzeichnis – Band 45
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- 567
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Synthesis and Evaluation of Potent and Selective b3 Adrenergic Receptor Agonists Containing Acylsulfonamide, Sulfonylsulfonamide, and Sulfonylurea Carboxylic Acid IsosteresUehling, D.E. et al. | 2002
- 567
-
Synthesis and Evaluation of Potent and Selective β3 Adrenergic Receptor Agonists Containing Acylsulfonamide, Sulfonylsulfonamide, and Sulfonylurea Carboxylic Acid Isosteres †Uehling, David E. / Donaldson, Kelly H. / Deaton, David N. / Hyman, Clifton E. / Sugg, Elizabeth E. / Barrett, David G. / Hughes, Robert G. / Reitter, Barbara / Adkison, Kim K. / Lancaster, Mary E. et al. | 2002
- 584
-
Identification of a Second Binding Site in the Estrogen Receptorvan Hoorn, Willem P. et al. | 2002
- 590
-
Antitumor Polycyclic Acridines. 8.1 Synthesis and Telomerase-Inhibitory Activity of Methylated Pentacyclic Acridinium SaltsHeald, R.A. et al. | 2002
- 590
-
Antitumor Polycyclic Acridines. 8. Synthesis and Telomerase-Inhibitory Activity of Methylated Pentacyclic Acridinium SaltsHeald, Robert A. / Modi, Chetna / Cookson, Jenny C. / Hutchinson, Ian / Laughton, Charles A. / Gowan, Sharon M. / Kelland, Lloyd R. / Stevens, Malcolm F. G. et al. | 2002
- 598
-
Synthesis and Biological Activity of a Novel Class of Small Molecular Weight Peptidomimetic Competitive Inhibitors of Protein Tyrosine Phosphatase 1BLarsen, Scott D. / Barf, Tjeerd / Liljebris, Charlotta / May, Paul D. / Ogg, Derek / O'Sullivan, Theresa J. / Palazuk, Barbara J. / Schostarez, Heinrich J. / Stevens, F. Craig / Bleasdale, John E. et al. | 2002
- 623
-
Synthesis and Preliminary Characterization of a Novel Antiarrhythmic Compound (KB130015) with an Improved Toxicity Profile Compared with AmiodaroneCarlsson, Bo / Singh, B. N. / Temciuc, Marcel / Nilsson, Stefan / Li, Yi-Lin / Mellin, Charlotta / Malm, Johan et al. | 2002
- 631
-
Design, Synthesis, and Evaluation of Novel 2-Substituted 3-Hydroxypyridin-4-ones: Structure−Activity Investigation of Metalloenzyme Inhibition by Iron Chelators §Liu, Zu D. / Kayyali, Reem / Hider, Robert C. / Porter, John B. / Theobald, Anthony E. et al. | 2002
- 640
-
Synthesis and Optimization of a New Family of Type 3 17β-Hydroxysteroid Dehydrogenase Inhibitors by Parallel Liquid-Phase ChemistryMaltais, René / Luu-The, Van / Poirier, Donald et al. | 2002
- 640
-
Synthesis and Optimization of a New Family of Type 3 17beta-Hydroxysteroid Dehydrogenase Inhibitors by Parallel Liquid-Phase ChemistryMaltais, R. / Luu-The, V. / Poirier, D. et al. | 2002
- 640
-
Synthesis and Optimization of a New Family of Type 3 17b-Hydroxysteroid Dehydrogenase Inhibitors by Parallel Liquid-Phase ChemistryMaltais, R. et al. | 2002
- 654
-
Expansion of Structure−Activity Studies of Piperidine Analogues of 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) Compounds by Altering Substitutions in the N-Benzyl Moiety and Behavioral Pharmacology of Selected MoleculesDutta, Aloke K. / Davis, Matthew C. / Fei, Xiang-Shu / Beardsley, Patrick M. / Cook, Charles D. / Reith, Maarten. E. A. et al. | 2002
- 663
-
Correlation of the Antibacterial Activities of Cationic Peptide Antibiotics and Cationic Steroid AntibioticsDing, Bangwei / Guan, Qunying / Walsh, Joshua P. / Boswell, J. Scott / Winter, Tim W. / Winter, Erica S. / Boyd, Stephanie S. / Li, Chunhong / Savage, Paul B. et al. | 2002
- 663
-
Correlation of the Antibacterial Activities of Cationic Peptide Antibiotics and Cationic Steroid Antibiotics1Ding, B. et al. | 2002
- 670
-
Design and Synthesis of Motilin Antagonists Derived from the [1−4] Fragment of Porcine MotilinHaramura, Masayuki / Okamachi, Akira / Tsuzuki, Kouichi / Yogo, Kenji / Ikuta, Makoto / Kozono, Toshiro / Takanashi, Hisanori / Murayama, Eigoro et al. | 2002
- 676
-
Identification of Potent and Selective Mechanism-Based Inhibitors of the Cysteine Protease Cruzain Using Solid-Phase Parallel SynthesisHuang, Lily / Lee, Alice / Ellman, Jonathan A. et al. | 2002
- 685
-
Synthesis of 1-(3,4-Dihydroxy-5-nitrophenyl)-2-phenyl-ethanone and Derivatives as Potent and Long-Acting Peripheral Inhibitors of Catechol-O-methyltransferaseLearmonth, David A. / Vieira-Coelho, Maria A. / Benes, Jan / Alves, Paula C. / Borges, Nuno / Freitas, Ana P. / Soares-da-Silva, Patrício et al. | 2002
- 696
-
2,6-Di(ω-aminoalkyl)-2,5,6,7-tetrahydropyrazolo[3,4,5-mn]pyrimido[5,6,1-de]acridine-5,7-diones: Novel, Potent, Cytotoxic, and DNA-Binding AgentsAntonini, Ippolito / Polucci, Paolo / Magnano, Amelia / Gatto, Barbara / Palumbo, Manlio / Menta, Ernesto / Pescalli, Nicoletta / Martelli, Sante et al. | 2002
- 696
-
2,6-Di(w-aminoalkyl)-2,5,6,7-tetrahydropyrazolo(3,4,5-mn)pyrimido(5- ,6,1-de)acridine-5,7-diones: Novel, Potent, Cytotoxic, and DNA-Binding AgentsAntonini, I. et al. | 2002
- 696
-
2,6-Di(omega-aminoalkyl)-2,5,6,7-tetrahydropyrazolo-[3,4,5-mn]pyrimi do[5,6,1-de]acridine-5,7-diones: Novel, Potent, Cytotoxic, and DNA-Binding AgentsAntonini, I. / Polucci, P. / Magnano, A. / Gatto, B. / Palumbo, M. / Menta, E. / Pescalli, N. / Martelli, S. et al. | 2002
- 703
-
Novel Mycophenolic Adenine Bis(phosphonate) Analogues As Potential Differentiation Agents against Human LeukemiaPankiewicz, Krzysztof W. / Lesiak-Watanabe, Krystyna B. / Watanabe, Kyoichi A. / Patterson, Steven E. / Jayaram, Hiremagalur N. / Yalowitz, Joel A. / Miller, Michael D. / Seidman, Michael / Majumdar, Alokes / Prehna, Gerd et al. | 2002
- 703
-
Novel Mycophenolic Adenine Bis(phosphonate) Analogues As Potential Differentiation Agents against Human Leukemia1Pankiewicz, K.W. et al. | 2002
- 713
-
Evaluation of the Dmt−Tic Pharmacophore: Conversion of a Potent δ-Opioid Receptor Antagonist into a Potent δ Agonist and Ligands with Mixed PropertiesBalboni, Gianfranco / Guerrini, Remo / Salvadori, Severo / Bianchi, Clementina / Rizzi, Daniela / Bryant, Sharon D. / Lazarus, Lawrence H. et al. | 2002
- 713
-
Evaluation of the Dmt-Tic Pharmacophore: Conversion of a Potent d-Opioid Receptor Antagonist into a Potent d Agonist and Ligands with Mixed PropertiesBalboni, G. et al. | 2002
- 713
-
Evaluation of the Dmt-Tic Pharmacophore: Conversion of a Potent delta-Opioid Receptor Antagonist into a Potent delta Agonist and Ligands with Mixed PropertiesBalboni, G. / Guerrini, R. / Salvadori, S. / Bianchi, C. / Rizzi, D. / Bryant, S. D. / Lazarus, L. H. et al. | 2002
- 721
-
Novel Angular Benzophenazines: Dual Topoisomerase I and Topoisomerase II Inhibitors as Potential Anticancer AgentsVicker, Nigel / Burgess, Luke / Chuckowree, Irina S. / Dodd, Rory / Folkes, Adrian J. / Hardick, David J. / Hancox, Timothy C. / Miller, Warren / Milton, John / Sohal, Sukhjit et al. | 2002
- 740
-
Structure−Activity Relationships for Pyrido-, Imidazo-, Pyrazolo-, Pyrazino-, and Pyrrolophenazinecarboxamides as Topoisomerase-Targeted Anticancer AgentsGamage, Swarna A. / Spicer, Julie A. / Rewcastle, Gordon W. / Milton, John / Sohal, Sukhjit / Dangerfield, Wendy / Mistry, Prakash / Vicker, Nigel / Charlton, Peter A. / Denny, William A. et al. | 2002
- 744
-
Antitumor Benzothiazoles. 16.1 Synthesis and Pharmaceutical Properties of Antitumor 2-(4-Aminophenyl)benzothiazole Amino Acid ProdrugsHutchinson, I. et al. | 2002
- 744
-
Antitumor Benzothiazoles. 16. Synthesis and Pharmaceutical Properties of Antitumor 2-(4-Aminophenyl)benzothiazole Amino Acid ProdrugsHutchinson, Ian / Jennings, Sharon A. / Vishnuvajjala, B. Rao / Westwell, Andrew D. / Stevens, Malcolm F. G. et al. | 2002
- 748
-
New Neplanocin Analogues. 12. Alternative Synthesis and Antimalarial Effect of (6'R)-6'-C-Methylneplanocin A, a Potent AdoHcy Hydrolase Inhibitor1Shuto, S. et al. | 2002
- 748
-
New Neplanocin Analogues. 12. Alternative Synthesis and Antimalarial Effect of (6‘R)-6‘-C-Methylneplanocin A, a Potent AdoHcy Hydrolase InhibitorShuto, Satoshi / Minakawa, Noriaki / Niizuma, Satoshi / Kim, Hye-Sook / Wataya, Yusuke / Matsuda, Akira et al. | 2002
- 752
-
Synthesis and Comparative Molecular Field Analysis (CoMFA) of Symmetric and Nonsymmetric Cyclic Sulfamide HIV-1 Protease Inhibitors.Schaal, Wesley / Karlsson, Anna / Ahlsén, Göran / Lindberg, Jimmy / Andersson, Hans O. / Danielson, U. Helena / Classon, Björn / Unge, Torsten / Samuelsson, Bertil / Hultén, Johan et al. | 2002
- 753
-
Inhibitors of Human Histone Deacetylase: Synthesis and Enzyme and Cellular Activity of Straight Chain HydroxamatesRemiszewski, Stacy W. / Sambucetti, Lidia C. / Atadja, Peter / Bair, Kenneth W. / Cornell, Wendy D. / Green, Michael A. / Howell, Kobporn Lulu / Jung, Manfred / Kwon, Paul / Trogani, Nancy et al. | 2002
- 758
-
DNA Cleavage Potency, Cytotoxicity, and Mechanism of Action of a Novel Class of Enediyne ProdrugsDai, Wei-Min / Lai, Kwong Wah / Wu, Anxin / Hamaguchi, Wataru / Lee, Mavis Yuk Ha / Zhou, Ling / Ishii, Atsushi / Nishimoto, Sei-ichi et al. | 2002
- 762
-
Environmental Mimic of Receptor Interaction: Conformational Analysis of CCK-15 in SolutionAlbrizio, Stefania / Carotenuto, Alfonso / Fattorusso, Caterina / Moroder, Luis / Picone, Delia / Temussi, Piero A. / D'Ursi, Annamaria et al. | 2002
- 770
-
Synthesis, Biological Activity, and Molecular Modeling Investigation of New Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine Derivatives as Human A3 Adenosine Receptor AntagonistsBaraldi, Pier Giovanni / Cacciari, Barbara / Moro, Stefano / Spalluto, Giampiero / Pastorin, Giorgia / Da Ros, Tatiana / Klotz, Karl-Norbert / Varani, Katia / Gessi, Stefania / Borea, Pier Andrea et al. | 2002
- 781
-
A Three-Dimensional Quantitative Structure−Activity Relationship Study of Heparin-Binding Epidermal Growth Factor Shedding Inhibitors Using Comparative Molecular Field AnalysisBursi, Roberta / Sawa, Masaaki / Hiramatsu, Yasuyuki / Kondo, Hirosato et al. | 2002
- 789
-
Novel Tricyclic-a-alkyloxyphenylpropionic Acids: Dual PPARa-g Agonists with Hypolipidemic and Antidiabetic ActivitySauerberg, P. et al. | 2002
- 789
-
Novel Tricyclic-α-alkyloxyphenylpropionic Acids: Dual PPARα/γ Agonists with Hypolipidemic and Antidiabetic ActivitySauerberg, Per / Pettersson, Ingrid / Jeppesen, Lone / Bury, Paul S. / Mogensen, John P. / Wassermann, Karsten / Brand, Christian L. / Sturis, Jeppe / Wöldike, Helle F. / Fleckner, Jan et al. | 2002
- 789
-
Novel Tricyclic-alpha-alkyloxyphenylpropionic Acids: Dual PPARalpha/gamma Agonists with Hypolipidemic and Antidiabetic ActivitySauerberg, P. / Pettersson, I. / Jeppesen, L. / Bury, P. S. / Mogensen, J. P. / Wassermann, K. / Brand, C. L. / Sturis, J. / Woldike, H. F. / Fleckner, J. et al. | 2002
- 805
-
Minor Groove DNA Binders as Antimicrobial Agents. 1. Pyrrole Tetraamides Are Potent Antibacterials against Vancomycin Resistant Enteroccoci and Methicillin Resistant Staphylococcus aureusDyatkina, Natalia B. / Roberts, Christopher D. / Keicher, Jesse D. / Dai, Yuqin / Nadherny, Joshua P. / Zhang, Wentao / Schmitz, Uli / Kongpachith, Ana / Fung, Kevin / Novikov, Alexander A. et al. | 2002
- 818
-
Mining the National Cancer Institute's Tumor-Screening Database: Identification of Compounds with Similar Cellular ActivitiesRabow, Alfred A. / Shoemaker, Robert H. / Sausville, Edward A. / Covell, David G. et al. | 2002
- 841
-
CoMFA and CoMSIA 3D QSAR and Docking Studies on Conformationally-Restrained Cinnamoyl HIV-1 Integrase Inhibitors: Exploration of a Binding Mode at the Active SiteBuolamwini, John K. / Assefa, Haregewein et al. | 2002
- 853
-
Structural Basis of RasGRP Binding to High-Affinity PKC LigandsRong, Suo-Bao / Enyedy, Istvan J. / Qiao, Lixin / Zhao, Lianyun / Ma, Dawei / Pearce, Larry L. / Lorenzo, Patricia S. / Stone, James C. / Blumberg, Peter M. / Wang, Shaomeng et al. | 2002
- 861
-
DNA Cross-Linking by Azinomycin B: Monte Carlo Simulations in the Evaluation of Sequence SelectivityAlcaro, Stefano / Ortuso, Francesco / Coleman, Robert S. et al. | 2002
- 871
-
A 3·(ET743)-DNA Complex That Both Resembles an RNA-DNA Hybrid and Mimicks Zinc Finger-Induced DNA Structural DistortionsMarco, Esther / García-Nieto, Raquel / Mendieta, Jesús / Manzanares, Ignacio / Cuevas, Carmen / Gago, Federico et al. | 2002
- 881
-
Designing Analogues of Mini Atrial Natriuretic Peptide Based on Structural Analysis by NMR and Restrained Molecular DynamicsSugase, Kenji / Oyama, Yoshiaki / Kitano, Katsuhiko / Iwashita, Takashi / Fujiwara, Toshimichi / Akutsu, Hideo / Ishiguro, Masaji et al. | 2002
- 888
-
Structural Aspects of Isozyme Selectivity in the Binding of Inhibitors to Carbonic Anhydrases II and IVKim, Chu-Young / Whittington, Douglas A. / Chang, Jeanne S. / Liao, John / May, Jesse A. / Christianson, David W. et al. | 2002
- 894
-
Kinetic Studies of the Binding of Acridinecarboxamide Topoisomerase Poisons to DNA: Implications for Mode of Binding of Ligands with Uncharged ChromophoresWakelin, Laurence P. G. / Adams, Adrienne / Denny, William A. et al. | 2002
- 902
-
Pyridophens: Binary Pyridostigmine−Aprophen Prodrugs with Differential Inhibition of Acetylcholinesterase, Butyrylcholinesterase, and Muscarinic ReceptorsLeader, Haim / Wolfe, Alan David / Chiang, Peter K. / Gordon, Richard K. et al. | 2002
- 911
-
Cysteine Derivatives as Inhibitors for Carboxypeptidase A: Synthesis and Structure−Activity RelationshipsPark, Jung Dae / Kim, Dong H. et al. | 2002
- 919
-
New Type of Metalloproteinase Inhibitor: Design and Synthesis of New Phosphonamide-Based Hydroxamic AcidsSawa, Masaaki / Kiyoi, Takao / Kurokawa, Kiriko / Kumihara, Hiroshi / Yamamoto, Minoru / Miyasaka, Tomohiro / Ito, Yasuko / Hirayama, Ryoichi / Inoue, Tomomi / Kirii, Yasuyuki et al. | 2002
- 930
-
New Strategy for Antedrug Application: Development of Metalloproteinase Inhibitors as Antipsoriatic DrugsSawa, Masaaki / Tsukamoto, Takako / Kiyoi, Takao / Kurokawa, Kiriko / Nakajima, Fumio / Nakada, Yuichiro / Yokota, Koichi / Inoue, Yoshimasa / Kondo, Hirosato / Yoshino, Kohichiro et al. | 2002
- 937
-
Synthesis and Biological Activity of the Prodrug of Class I Major Histocompatibility Peptide GILGFVFTL Activated by beta-GlucuronidaseRawale, S. / Hrihorczuk, L. M. / Wei, W.-Z. / Zemlicka, J. et al. | 2002
- 937
-
Synthesis and Biological Activity of the Prodrug of Class I Major Histocompatibility Peptide GILGFVFTL Activated by β-GlucuronidaseRawale, Sharad / Hrihorczuk, Lew M. / Wei / Zemlicka, Jiri et al. | 2002
- 937
-
Synthesis and Biological Activity of the Prodrug of Class I Major Histocompatibility Peptide GILGFVFTL Activated by b-Glucuronidase1Rawale, S. et al. | 2002
- 944
-
N-Aryl N‘-Hydroxyguanidines, A New Class of NO-Donors after Selective Oxidation by Nitric Oxide Synthases: Structure−Activity RelationshipRenodon-Cornière, Axelle / Dijols, Sylvie / Perollier, Céline / Lefevre-Groboillot, David / Boucher, Jean-Luc / Attias, Roger / Sari, Marie-Agnes / Stuehr, Dennis / Mansuy, Daniel et al. | 2002
- 955
-
Syntheses, Calcium Channel Agonist−Antagonist Modulation Activities, Nitric Oxide Release, and Voltage-Clamp Studies of 2-Nitrooxyethyl 1,4-Dihydro- 2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate EnantiomersShan, Rudong / Howlett, Susan E. / Knaus, Edward E. et al. | 2002
- 962
-
Novel Antagonists Acting at the P2Y1 Purinergic Receptor: Synthesis and Conformational Analysis Using Potentiometric and Nuclear Magnetic Resonance Titration TechniquesRaboisson, Pierre / Baurand, Anthony / Cazenave, Jean-Pierre / Gachet, Christian / Retat, Myriam / Spiess, Bernard / Bourguignon, Jean-Jacques et al. | 2002
- 973
-
Computational Studies on Tetrahydropyrimidine-2-one HIV-1 Protease Inhibitors: Improving Three-Dimensional Quantitative Structure−Activity Relationship Comparative Molecular Field Analysis Models by Inclusion of Calculated Inhibitor- and Receptor-Based PropertiesNair, Anil C. / Jayatilleke, Philippa / Wang, Xia / Miertus, Stanislav / Welsh, William J. et al. | 2002
- 984
-
Cyclohexylmethylpiperidinyltriphenylpropioamide: A Selective Muscarinic M3 Antagonist Discriminating against the Other Receptor SubtypesSagara, Yufu / Sagara, Takeshi / Mase, Toshiaki / Kimura, Toshifumi / Numazawa, Tomoshige / Fujikawa, Toru / Noguchi, Kazuhito / Ohtake, Norikazu et al. | 2002
- 988
-
Selective Antagonists at Group I Metabotropic Glutamate Receptors: Synthesis and Molecular Pharmacology of 4-Aryl-3-isoxazolol Amino AcidsKromann, Hasse / Sløk, Frank A. / Stensbøl, Tine B. / Bräuner-Osborne, Hans / Madsen, Ulf / Krogsgaard-Larsen, Povl et al. | 2002
- 992
-
Medicinal Chemistry into the Millennium Edited by M. M. Campbell and I. S. Blagbrough. The Royal Society of Chemistry, Cambridge, U.K. 2001. x + 398 pp. 16 × 24 cm. ISBN 0-854-04-769-7. £69.50.Wolff, Manfred E. et al. | 2002
- 992
-
Medicinal Chemistry into the Millennium Edited by M. M. Campbell and I. S. Blagbrough. The Royal Society of Chemistry, Cambridge, U.K. 2001. x + 398 pp. 16 x 24 cm. ISBN 0-854-04-769-7. (GBP)69.50.Wolff, M.E. et al. | 2002
- 992
-
The Sigma-RBI Handbook of Receptor Classification and Signal Transduction. Fourth Edition Edited by Keith J. Watling. Sigma-RBI, Natick, MA. 2001. viii + 231 pp. 28 x 23 cm. ISBN 0-9640548-3-3. 55.00.Cannon, J.G. et al. | 2002
- 992
-
The Sigma-RBI Handbook of Receptor Classification and Signal Transduction. Fourth Edition Edited by Keith J. Watling. Sigma-RBI, Natick, MA. 2001. viii + 231 pp. 28 × 23 cm. ISBN 0-9640548-3-3. $55.00.Cannon, Joseph G. et al. | 2002
- 993
-
Quantitative Chromatographic Analysis. Volume 85 By Thomas Beesley, Benjamin Buglio, and P. W. Scott. Marcel Dekker, New York, 2001. xx + 378 pp. 15 x 23 cm. ISBN 0-8247-0503-3. 150.00.Born, J.L. et al. | 2002
- 993
-
Advances in Chromatography. Volume 41 Edited by Phyllis R. Brown and Eli Grushka. Marcel Dekker, New York. 2001. xx + 425 pp. 15 × 23 cm. ISBN 0-8247-0509-2. $195.00.Born, Jerry L. et al. | 2002
- 993
-
The Handbook of Nucleoside Synthesis By Helmut Vorbrüggen and Carmen Ruh-Pohlenz. John Wiley & Sons, New York. 2001. xii + 631 pp. 15.5 x 23 cm. ISBN 0-471-09383-1 (paper). 79.95.Bergstrom, D.E. et al. | 2002
- 993
-
The Handbook of Nucleoside Synthesis By Helmut Vorbrüggen and Carmen Ruh-Pohlenz. John Wiley & Sons, New York. 2001. xii + 631 pp. 15.5 × 23 cm. ISBN 0-471-09383-1 (paper). $79.95.Bergstrom, Donald E. et al. | 2002
- 993
-
Quantitative Chromatographic Analysis. Volume 85 By Thomas Beesley, Benjamin Buglio, and P. W. Scott. Marcel Dekker, New York, 2001. xx + 378 pp. 15 × 23 cm. ISBN 0-8247-0503-3. $150.00.Born, Jerry L. et al. | 2002
- 993
-
Advances in Chromatography. Volume 41 Edited by Phyllis R. Brown and Eli Grushka. Marcel Dekker, New York. 2001. xx + 425 pp. 15 x 23 cm. ISBN 0-8247-0509-2. 195.00.Born, J.L. et al. | 2002
- 995
-
Rhodacyanine Dyes as Antimalarials. 1. Preliminary Evaluation of Their Activity and ToxicityTakasu, Kiyosei / Inoue, Hiroshi / Kim, Hye-Sook / Suzuki, Makoto / Shishido, Tadao / Wataya, Yusuke / Ihara, Masataka et al. | 2002
- 999
-
Identification of Novel Inhibitors of the Transforming Growth Factor beta1 (TGF-beta1) Type 1 Receptor (ALK5)Callahan, J. F. / Burgess, J. L. / Fornwald, J. A. / Gaster, L. M. / Harling, J. D. / Harrington, F. P. / Heer, J. / Kwon, C. / Lehr, R. / Mathur, A. et al. | 2002
- 999
-
Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)Callahan, James F. / Burgess, Joelle L. / Fornwald, James A. / Gaster, Laramie M. / Harling, John D. / Harrington, Frank P. / Heer, Jag / Kwon, Chet / Lehr, Ruth / Mathur, A. et al. | 2002
- 999
-
Identification of Novel Inhibitors of the Transforming Growth Factor b1 (TGF-b1) Type 1 Receptor (ALK5)Callahan, J.F. et al. | 2002
- 1002
-
Bis(1H-2-indolyl)methanones as a Novel Class of Inhibitors of the Platelet-Derived Growth Factor Receptor KinaseMahboobi, Siavosh / Teller, Steffen / Pongratz, Herwig / Hufsky, Harald / Sellmer, Andreas / Botzki, Alexander / Uecker, Andrea / Beckers, Thomas / Baasner, Silke / Schächtele, Christoph et al. | 2002
- 1019
-
Solution Structure of a Putative HIV1 Immunogenic Peptide: Computer Simulation of the Principal CD4 Binding Domain of gp120Mihailescu, Dan / Smith, Jeremy C. / Reed, Jennifer et al. | 2002
- 1026
-
Secondary Structure of the Third Extracellular Loop Responsible for Ligand Selectivity of a Mammalian Gonadotropin-Releasing Hormone ReceptorPetry, Renate / Craik, David / Haaima, Gerald / Fromme, Bernhard / Klump, Horst / Kiefer, Wolfgang / Palm, Dieter / Millar, Robert et al. | 2002
- 1035
-
Synthesis and Biological Evaluation of a New Set of Pyrazolo[1,5-c]quinazoline-2-carboxylates as Novel Excitatory Amino Acid AntagonistsVarano, Flavia / Catarzi, Daniela / Colotta, Vittoria / Filacchioni, Guido / Galli, Alessandro / Costagli, Chiara / Carlà, Vincenzo et al. | 2002
- 1045
-
Nanomolar Small Molecule Inhibitors for avb6, avb5, and avb3 IntegrinsGoodman, S.L. et al. | 2002
- 1045
-
Nanomolar Small Molecule Inhibitors for αvβ6, αvβ5, and αvβ3 IntegrinsGoodman, Simon L. / Hölzemann, Günter / Sulyok, Gábor A. G. / Kessler, Horst et al. | 2002
- 1045
-
Nanomolar Small Molecule Inhibitors for alphavbeta6, alphavbeta5, and alphavbeta3 IntegrinsGoodman, S. L. / Holzemann, G. / Sulyok, G. A. G. / Kessler, H. et al. | 2002
- 1052
-
Mechanism-Based Design of Parasite-Targeted Artemisinin Derivatives: Synthesis and Antimalarial Activity of New Diamine Containing AnaloguesHindley, Stephen / Ward, Stephen A. / Storr, Richard C. / Searle, Natalie L. / Bray, Patrick G. / Park, B. Kevin / Davies, Jill / O'Neill, Paul M. et al. | 2002
- 1064
-
Synthesis and Nicotinic Binding Studies on Enantiopure Diazine Analogues of the Novel (2-Chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165Gohlke, Holger / Gündisch, Daniela / Schwarz, Simone / Seitz, Gunther / Tilotta, Maria Cristina / Wegge, Thomas et al. | 2002
- 1073
-
Synthesis and Biolocalization of Water-Soluble SapphyrinsKrál, Vladimir / Davis, Julian / Andrievsky, Andrei / Kralová, Jarmila / Synytsya, Alla / Poucková, Pavla / Sessler, Jonathan L. et al. | 2002
- 1079
-
Synthesis and Antitumor Activity of Several New Analogues of Penclomedine and Its MetabolitesTiwari, Anita / Riordan, James M. / Waud, William R. / Struck, Robert F. et al. | 2002
- 1086
-
6-Sulfonylchromenes as Highly Potent KATP-Channel OpenersSalamon, Ekkehart / Mannhold, Raimund / Weber, Horst / Lemoine, Horst / Frank, Walter et al. | 2002
- 1098
-
Feature Selection for Structure−Activity Correlation Using Binary Particle SwarmsAgrafiotis, Dimitris K. / Cedeño, Walter et al. | 2002
- 1108
-
Side-Chain Lactam-Bridge Conformational Constraints Differentiate the Activities of Salmon and Human Calcitonins and Reveal a New Design Concept for Potent Calcitonin AnaloguesTaylor, John W. / Jin, Qian K. / Sbacchi, Massimo / Wang, Lu / Belfiore, Piero / Garnier, Martine / Kazantzis, Athanasios / Kapurniotu, Aphrodite / Zaratin, Paola F. / Scheideler, Mark A. et al. | 2002
- 1122
-
Synthesis, Pharmacokinetics, Efficacy, and Rat Retinal Toxicity of a Novel Mitomycin C-Triamcinolone Acetonide ConjugateMacky, Tamer A. / Oelkers, Carsten / Rix, Uwe / Heredia, Martin L. / Künzel, Eva / Wimberly, Mark / Rohrer, Baerbel / Crosson, Craig E. / Rohr, Jürgen et al. | 2002
- 1128
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Development of a New Class of Nonimidazole Histamine H3 Receptor Ligands with Combined Inhibitory Histamine N-Methyltransferase ActivityApelt, Joachim / Ligneau, Xavier / Pertz, Heinz H. / Arrang, Jean-Michel / Ganellin, C. Robin / Schwartz, Jean-Charles / Schunack, Walter / Stark, Holger et al. | 2002
- 1142
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New Stereocontrolled Synthesis and Biological Evaluation of 5-(1‘-Hydroxyalkyl)-3-methylidenetetrahydro-2-furanones as Potential Cytotoxic AgentsJanecki, Tomasz / Błaszczyk, Edyta / Studzian, Kazimierz / Różalski, Marek / Krajewska, Urszula / Janecka, Anna et al. | 2002
- 1146
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Synthesis and Biological Evaluation of a New Furo[2,3-h]quinolin-2(1H)-oneChilin, Adriana / Marzano, Christine / Guiotto, Adriano / Baccichetti, Francarosa / Carlassare, Francesco / Bordin, Franco et al. | 2002
- 1150
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Reduction in Glucose Levels in STZ Diabetic Rats by 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid: A Prodrug Approach for Targeting the Liver.Bebernitz, Gregory R. / Dain, Jeremy G. / Deems, Rhonda O. / Otero, Dario A. / Simpson, W. Ronald / Strohschein, Robert J. et al. | 2002
- 1151
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Serine−Threonine Protein Phosphatase Inhibitors: Development of Potential Therapeutic StrategiesMcCluskey, Adam / Sim, Alistair T. R. / Sakoff, Jennette A. et al. | 2002
- 1176
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6,7-Dihydro-2-benzothiophen-4(5H)-ones: A Novel Class of GABA-A a5 Receptor Inverse AgonistsChambers, M.S. et al. | 2002
- 1176
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6,7-Dihydro-2-benzothiophen-4(5H)-ones: A Novel Class of GABA-A alpha5 Receptor Inverse AgonistsChambers, M. S. / Atack, J. R. / Bromidge, F. A. / Broughton, H. B. / Cook, S. / Dawson, G. R. / Hobbs, S. C. / Maubach, K. A. / Reeve, A. J. / Seabrook, G. R. et al. | 2002
- 1176
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6,7-Dihydro-2-benzothiophen-4(5H)-ones: A Novel Class of GABA-A α5 Receptor Inverse AgonistsChambers, Mark S. / Atack, John R. / Bromidge, Frances A. / Broughton, Howard B. / Cook, Susan / Dawson, Gerard R. / Hobbs, Sarah C. / Maubach, Karen A. / Reeve, Austin J. / Seabrook, Guy R. et al. | 2002
- 1180
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3-(1H-Pyrrol-1-yl)-2-oxazolidinones as Reversible, Highly Potent, and Selective Inhibitors of Monoamine Oxidase Type AMai, Antonello / Artico, Marino / Esposito, Monica / Sbardella, Gianluca / Massa, Silvio / Befani, Olivia / Turini, Paola / Giovannini, Valentina / Mondovì, Bruno et al. | 2002
- 1184
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Synthesis and X-ray Studies of Chiral Allosteric Modifiers of HemoglobinYoussef, Amal Mamdouh / Safo, Martin K. / Danso-Danquah, Richmond / Joshi, Gajanan S. / Kister, Jean / Marden, Michael C. / Abraham, Donald J. et al. | 2002
- 1196
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Ribose-Modified Nucleosides as Ligands for Adenosine Receptors: Synthesis, Conformational Analysis, and Biological Evaluation of 1‘-C-Methyl Adenosine AnaloguesCappellacci, Loredana / Barboni, Grazia / Palmieri, Micaela / Pasqualini, Michela / Grifantini, Mario / Costa, Barbara / Martini, Claudia / Franchetti, Palmarisa et al. | 2002
- 1203
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Synthesis and Biological Evaluation of 2-Substituted 3beta-Tolyltropane Derivatives at Dopamine, Serotonin, and Norepinephrine TransportersXu, L. / Izenwasser, S. / Katz, J. L. / Kopajtic, T. / Klein-Stevens, C. / Zhu, N. / Lomenzo, S. A. / Winfield, L. / Trudell, M. L. et al. | 2002
- 1203
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Synthesis and Biological Evaluation of 2-Substituted 3b-Tolyltropane Derivatives at Dopamine, Serotonin, and Norepinephrine TransportersXu, L. et al. | 2002
- 1203
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Synthesis and Biological Evaluation of 2-Substituted 3β-Tolyltropane Derivatives at Dopamine, Serotonin, and Norepinephrine TransportersXu, Lifen / Izenwasser, Sari / Katz, Jonathan L. / Kopajtic, Theresa / Klein-Stevens, Cheryl / Zhu, Naiju / Lomenzo, Stacey A. / Winfield, Leyte / Trudell, Mark L. et al. | 2002
- 1211
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A Comprehensive Study of the Active Site Residues of DT-Diaphorase: Rational Design of Benzimidazolediones as DT-Diaphorase Substrates †Suleman, Ali / Skibo, Edward B. et al. | 2002
- 1221
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PRO_SELECT: Combining Structure-Based Drug Design and Array-Based Chemistry for Rapid Lead Discovery. 2. The Development of a Series of Highly Potent and Selective Factor Xa InhibitorsLiebeschuetz, John W. / Jones, Stuart D. / Morgan, Phillip J. / Murray, Chris W. / Rimmer, Andrew D. / Roscoe, Jonathan M. E. / Waszkowycz, Bohdan / Welsh, Pauline M. / Wylie, William A. / Young, Stephen C. et al. | 2002
- 1233
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Designing Small, Nonsugar Activators of Antithrombin Using Hydropathic Interaction Analyses †Gunnarsson, Gunnar T. / Desai, Umesh R. et al. | 2002
- 1244
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Development of 2,4-Diaminopyrimidines as Antimalarials Based on Inhibition of the S108N and C59R+S108N Mutants of Dihydrofolate Reductase from Pyrimethamine-Resistant Plasmodium f alciparumTarnchompoo, Bongkoch / Sirichaiwat, Chawanee / Phupong, Worrapong / Intaraudom, Chakapong / Sirawaraporn, Worachart / Kamchonwongpaisan, Sumalee / Vanichtanankul, Jarunee / Thebtaranonth, Yodhathai / Yuthavong, Yongyuth et al. | 2002
- 1253
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Substituted Diphenyl Sulfides as Selective Serotonin Transporter Ligands: Synthesis and In Vitro EvaluationEmond, Patrick / Vercouillie, Johnny / Innis, Robert / Chalon, Sylvie / Mavel, Sylvie / Frangin, Yves / Halldin, Christer / Besnard, Jean-Claude / Guilloteau, Denis et al. | 2002
- 1259
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Substituted Pentacyclic Carbazolones as Novel Muscarinic Allosteric Agents: Synthesis and Structure−Affinity and Cooperativity RelationshipsGharagozloo, Parviz / Lazareno, Sebastian / Miyauchi, Masao / Popham, Angela / Birdsall, Nigel J. M. et al. | 2002
- 1275
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Synthesis of New Covalently Bound k-Carrageenan-AZT Conjugates with Improved Anti-HIV ActivitiesVlieghe, P. et al. | 2002
- 1275
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Synthesis of New Covalently Bound κ-Carrageenan−AZT Conjugates with Improved Anti-HIV ActivitiesVlieghe, Patrick / Clerc, Thierry / Pannecouque, Christophe / Witvrouw, Myriam / De Clercq, Erik / Salles, Jean-Pierre / Kraus, Jean-Louis et al. | 2002
- 1275
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Synthesis of New Covalently Bound kappa-Carrageenan-AZT Conjugates with Improved Anti-HIV ActivitiesVlieghe, P. / Clerc, T. / Pannecouque, C. / Witvrouw, M. / De Clercq, E. / Salles, J.-P. / Kraus, J.-L. et al. | 2002
- 1284
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Carbocyclic Dinucleoside Polyphosphonates: Interaction with HIV Reverse Transcriptase and Antiviral Activity †Khandazhinskaya, Anastasya L. / Shirokova, Elena A. / Skoblov, Yurii S. / Victorova, Lyubov S. / Goryunova, Ludmila Ye. / Beabealashvilli, Robert S. / Pronyaeva, Tatyana R. / Fedyuk, Nina V. / Zolin, Vladimir V. / Pokrovsky, Andrey G. et al. | 2002
- 1292
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First Non-ATP Competitive Glycogen Synthase Kinase 3 β (GSK-3β) Inhibitors: Thiadiazolidinones (TDZD) as Potential Drugs for the Treatment of Alzheimer's DiseaseMartinez, Ana / Alonso, Mercedes / Castro, Ana / Pérez, Concepción / Moreno, Francisco J. et al. | 2002
- 1292
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First Non-ATP Competitive Glycogen Synthase Kinase 3 b (GSK-3b) Inhibitors: Thiadiazolidinones (TDZD) as Potential Drugs for the Treatment of Alzheimer's DiseaseMartinez, A. et al. | 2002
- 1292
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First Non-ATP Competitive Glycogen Synthase Kinase 3 beta (GSK-3beta) Inhibitors: Thiadiazolidinones (TDZD) as Potential Drugs for the Treatment of Alzheimer's DiseaseMartinez, A. / Alonso, M. / Castro, A. / Perez, C. / Moreno, F. J. et al. | 2002
- 1300
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Novel 4-Anilinoquinazolines with C-7 Basic Side Chains: Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase InhibitorsHennequin, Laurent F. / Stokes, Elaine S. E. / Thomas, Andrew P. / Johnstone, Craig / Plé, Patrick A. / Ogilvie, Donald J. / Dukes, Michael / Wedge, Stephen R. / Kendrew, Jane / Curwen, Jon O. et al. | 2002
- 1313
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Structure−Activity Relationships of 2‘-Fluoro-2‘,3‘-unsaturated d-Nucleosides as Anti-HIV-1 AgentsLee, Kyeong / Choi, Yongseok / Gumina, Giuseppe / Zhou, Wen / Schinazi, Raymond F. / Chu, Chung K. et al. | 2002
- 1321
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Development of Long-Acting Dopamine Transporter Ligands as Potential Cocaine-Abuse Therapeutic Agents: Chiral Hydroxyl-Containing Derivatives of 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazineHsin, Ling-Wei / Dersch, Christina M. / Baumann, Michael H. / Stafford, David / Glowa, John R. / Rothman, Richard B. / Jacobson, Arthur E. / Rice, Kenner C. et al. | 2002
- 1330
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Syntheses and Antiproliferative Activities of New Rebeccamycin Derivatives with the Sugar Unit Linked to Both Indole NitrogensMarminon, Christelle / Anizon, Fabrice / Moreau, Pascale / Léonce, Stéphane / Pierré, Alain / Pfeiffer, Bruno / Renard, Pierre / Prudhomme, Michelle et al. | 2002
- 1340
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Synthesis and Mode of Action of Hydrophobic Derivatives of the Glycopeptide Antibiotic Eremomycin and Des-(N-methyl-d-leucyl)eremomycin against Glycopeptide-Sensitive and -Resistant BacteriaPrintsevskaya, Svetlana S. / Pavlov, Andrey Y. / Olsufyeva, Evgenia N. / Mirchink, Elena P. / Isakova, Elena B. / Reznikova, Marina I. / Goldman, Robert C. / Branstrom, Arthur A. / Baizman, Eugene R. / Longley, Clifford B. et al. | 2002
- 1348
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Design and Synthesis of a Novel and Potent Series of Inhibitors of Cytosolic Phospholipase A2 Based on a 1,3-Disubstituted Propan-2-one SkeletonConnolly, Stephen / Bennion, Colin / Botterell, Sarah / Croshaw, Pamela J. / Hallam, Catherine / Hardy, Kim / Hartopp, Paul / Jackson, Clive G. / King, Sarah J. / Lawrence, Louise et al. | 2002
- 1363
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Stereochemistry at Phosphorus of the Reaction Catalyzed by m yo-Inositol MonophosphataseFauroux, Christine M.-J. / Lee, Michael / Cullis, Paul M. / Douglas, Kenneth T. / Gore, Michael G. / Freeman, Sally et al. | 2002
- 1374
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Synthesis and Notable Antimalarial Activity of Acyclic Peroxides, 1-(Alkyldioxy)-1-(methyldioxy)cyclododecanesHamada, Yoshiaki / Tokuhara, Hidekazu / Masuyama, Araki / Nojima, Masatomo / Kim, Hye-Sook / Ono, Kanako / Ogura, Naoki / Wataya, Yusuke et al. | 2002
- 1379
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Design and Synthesis of a Novel L-Dopa−Entacapone CodrugLeppänen, Jukka / Huuskonen, Juhani / Nevalainen, Tapio / Gynther, Jukka / Taipale, Hannu / Järvinen, Tomi et al. | 2002
- 1383
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Synthesis and Antimycobacterial Activity of 6-Arylpurines: The Requirements for the N-9 Substituent in Active Antimycobacterial PurinesGundersen, Lise-Lotte / Nissen-Meyer, Jon / Spilsberg, Bjørn et al. | 2002
- 1387
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Lipoamino Acid-Based Adjuvant Carrier System: Enhanced Immunogenicity of Group A Streptococcal Peptide EpitopesHorváth, Anikó / Olive, Colleen / Wong, Allan / Clair, Timothy / Yarwood, Penny / Good, Michael / Toth, Istvan et al. | 2002
- 1391
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Combinatorial Library Design and Evaluation Edited by Arup K. Ghose and Vellarkad N. Viswanadhan. Marcel Dekker Inc., New York. 2001. xv + 631 pp. 16 x 23.5 cm. ISBN 0-8247-0487-8. 195.00.Wasley, J.W.F. et al. | 2002
- 1391
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The Nitro Group in Organic Synthesis By Noboru Ono. Wiley-VCH, New York. 2001. xvi + 372 pp. 16 x 24 cm. ISBN 0-471-31611-3. 130.00.Currie, B.L. et al. | 2002
- 1391
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Combinatorial Library Design and Evaluation Edited by Arup K. Ghose and Vellarkad N. Viswanadhan. Marcel Dekker Inc., New York. 2001. xv + 631 pp. 16 × 23.5 cm. ISBN 0-8247-0487-8. $195.00.Wasley, Jan W. F. et al. | 2002
- 1391
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The Nitro Group in Organic Synthesis By Noboru Ono. Wiley-VCH, New York. 2001. xvi + 372 pp. 16 × 24 cm. ISBN 0-471-31611-3. $130.00.Currie, Bruce L. et al. | 2002
- 1391
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Combinatorial Library Design and EvaluationWasley, J. W. F. et al. | 2002
- 1391
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The Nitro Group in Organic SynthesisCurrie, B. L. et al. | 2002
- 1392
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Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th Edition Edited by J. G. Hardman, L. E. Limbird, and A. G. Gilman. McGraw Hill, New York. 2001. xxvii + 2148 pp. 21 × 26 cm. ISBN 0-07-1354469-7. $125.00.Patrick, Kennerly S. et al. | 2002
- 1392
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Chiral Intermediates Edited by Cynthia A. Challener. Ashgate Publishing, Burlington, VT. 2001. xxiii + 804 pp. 18 × 25 cm. ISBN 0-5660-8412-0. $295.00.Dussault, Patrick et al. | 2002
- 1392
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Methods in Enzymology. Volume 340. Drug-Nucleic Acid Interactions Edited by Jonathan B. Chaires and Michael J. Waring. Academic Press, New York. 2001. xxxiv + 705 pp. 16 x 23.5 cm. ISBN 0-12-182241-9. 129.95.Walters, D.E. et al. | 2002
- 1392
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Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th EditionPatrick, K. S. et al. | 2002
- 1392
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Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th Edition Edited by J. G. Hardman, L. E. Limbird, and A. G. Gilman. McGraw Hill, New York. 2001. xxvii + 2148 pp. 21 x 26 cm. ISBN 0-07-1354469-7. 125.00.Patrick, K.S. et al. | 2002
- 1392
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Chiral Intermediates Edited by Cynthia A. Challener. Ashgate Publishing, Burlington, VT. 2001. xxiii + 804 pp. 18 x 25 cm. ISBN 0-5660-8412-0. 295.00.Dussault, P. et al. | 2002
- 1392
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Methods in Enzymology. Volume 340. Drug−Nucleic Acid Interactions Edited by Jonathan B. Chaires and Michael J. Waring. Academic Press, New York. 2001. xxxiv + 705 pp. 16 × 23.5 cm. ISBN 0-12-182241-9. $129.95.Walters, D. Eric et al. | 2002
- 1392
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Methods in Enzymology. Volume 340. Drug-Nucleic Acid InteractionsWalters, D. E. et al. | 2002
- 1392
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Chiral IntermediatesDussault, P. et al. | 2002
- 1394
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Books of Interest| 2002
- 1394
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Book Review| 2002
- 1395
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Design, Synthesis, and Evaluation of Opioid Analogues with Non-Peptidic β-Turn Scaffold: Enkephalin and Endomorphin MimeticsEguchi, Masakatsu / Shen, Richard Y. W. / Shea, J. Paul / Lee, Min S. / Kahn, Michael et al. | 2002
- 1395
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Design, Synthesis, and Evaluation of Opioid Analogues with Non-Peptidic b-Turn Scaffold: Enkephalin and Endomorphin MimeticsEguchi, M. et al. | 2002
- 1395
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Design, Synthesis, and Evaluation of Opioid Analogues with Non-Peptidic beta-Turn Scaffold: Enkephalin and Endomorphin MimeticsEguchi, M. / Shen, R. Y. W. / Shea, J. P. / Lee, M. S. / Kahn, M. et al. | 2002
- 1399
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Toward Selective ERβ Agonists for Central Nervous System Disorders: Synthesis and Characterization of Aryl BenzthiophenesSchopfer, Ulrich / Schoeffter, Philippe / Bischoff, Serge F. / Nozulak, Joachim / Feuerbach, Dominik / Floersheim, Philipp et al. | 2002
- 1399
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Toward Selective ERb Agonists for Central Nervous System Disorders: Synthesis and Characterization of Aryl BenzthiophenesSchopfer, U. et al. | 2002
- 1399
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Toward Selective ERbeta Agonists for Central Nervous System Disorders: Synthesis and Characterization of Aryl BenzthiophenesSchopfer, U. / Schoeffter, P. / Bischoff, S. F. / Nozulak, J. / Feuerbach, D. / Floersheim, P. et al. | 2002
- 1402
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Identification of Novel Cyclooxygenase-2 Selective Inhibitors Using Pharmacophore ModelsPalomer, Albert / Cabré, Francesc / Pascual, Jaume / Campos, Joaquín / Trujillo, María A. / Entrena, Antonio / Gallo, Miguel A. / García, Lluïsa / Mauleón, David / Espinosa, Antonio et al. | 2002
- 1412
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Molecular Dynamics and Free Energy Analyses of Cathepsin D−Inhibitor Interactions: Insight into Structure-Based Ligand DesignHuo, Shuanghong / Wang, Junmei / Cieplak, Piotr / Kollman, Peter A. / Kuntz, Irwin D. et al. | 2002
- 1420
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Studies on the Mechanism of Hypoxic Selectivity in Copper Bis(Thiosemicarbazone) RadiopharmaceuticalsMaurer, Richard I. / Blower, Philip J. / Dilworth, Jonathan R. / Reynolds, Christopher A. / Zheng, Yifan / Mullen, Gregory E. D. et al. | 2002
- 1432
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Hydroxyethylamine Isostere of an HIV-1 Protease Inhibitor Prefers Its Amine to the Hydroxy Group in Binding to Catalytic Aspartates. A Synchrotron Study of HIV-1 Protease in Complex with a Peptidomimetic InhibitorDohnálek, Jan / Hašek, Jindřich / Dušková, Jarmila / Petroková, Hana / Hradilek, Martin / Souček, Milan / Konvalinka, Jan / Brynda, Jiří / Sedláček, Juraj / Fábry, Milan et al. | 2002
- 1439
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Structural Basis for the Glucocorticoid Response in a Mutant Human Androgen Receptor (ARccr) Derived from an Androgen-Independent Prostate CancerMatias, Pedro M. / Carrondo, Maria Arménia / Coelho, Ricardo / Thomaz, Monica / Zhao, Xiao-Yan / Wegg, Anja / Crusius, Kerstin / Egner, Ursula / Donner, Peter et al. | 2002
- 1447
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Molecular Interaction of the Antagonist N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 Cannabinoid ReceptorShim, Joong-Youn / Welsh, William J. / Cartier, Etienne / Edwards, James L. / Howlett, Allyn C. et al. | 2002
- 1460
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Modeling of Binding Modes and Inhibition Mechanism of Some Natural Ligands of Farnesyl Transferase Using Molecular DockingPedretti, Alessandro / Villa, Luigi / Vistoli, Giulio et al. | 2002
- 1466
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Carbonic Anhydrase Inhibitors. A General Approach for the Preparation of Water-Soluble Sulfonamides Incorporating Polyamino−Polycarboxylate Tails and of Their Metal Complexes Possessing Long-Lasting, Topical Intraocular Pressure-Lowering PropertiesScozzafava, Andrea / Menabuoni, Luca / Mincione, Francesco / Supuran, Claudiu T. et al. | 2002
- 1477
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Toward an Optimal Joint Recognition of the S1‘ Subsites of Endothelin Converting Enzyme-1 (ECE-1), Angiotensin Converting Enzyme (ACE), and Neutral Endopeptidase (NEP)Inguimbert, Nicolas / Coric, Pascale / Poras, Hervé / Meudal, Hervé / Teffot, Franck / Fournié-Zaluski, Marie-Claude / Roques, Bernard P. et al. | 2002
- 1487
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Synthesis and Structure−Activity Relationships of 3-Aryloxindoles: A New Class of Calcium-Dependent, Large Conductance Potassium (Maxi-K) Channel Openers with Neuroprotective PropertiesHewawasam, Piyasena / Erway, Matthew / Moon, Sandra L. / Knipe, Jay / Weiner, Harvey / Boissard, Christopher G. / Post-Munson, Debra J. / Gao, Qi / Huang, Stella / Gribkoff, Valentin K. et al. | 2002