Phenytoin stimulates chondrogenic differentiation in mouse clonal chondrogenic EC cells, ATDC5 (Englisch)
- Neue Suche nach: Okada, A.
- Neue Suche nach: Shiomi, T.
- Neue Suche nach: Aoki, Y.
- Neue Suche nach: Fujiwara, M.
- Neue Suche nach: Okada, A.
- Neue Suche nach: Shiomi, T.
- Neue Suche nach: Aoki, Y.
- Neue Suche nach: Fujiwara, M.
In:
JOURNAL OF TOXICOLOGICAL SCIENCES
;
30
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145-156
;
2005
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ISSN:
- Aufsatz (Zeitschrift) / Print
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Titel:Phenytoin stimulates chondrogenic differentiation in mouse clonal chondrogenic EC cells, ATDC5
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Beteiligte:Okada, A. ( Autor:in ) / Shiomi, T. ( Autor:in ) / Aoki, Y. ( Autor:in ) / Fujiwara, M. ( Autor:in )
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Erschienen in:JOURNAL OF TOXICOLOGICAL SCIENCES ; 30 ; 145-156
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Verlag:
- Neue Suche nach: JAPANESE SOCIETY OF TOXICOOGICAL SCIENCES
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Erscheinungsdatum:01.01.2005
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Format / Umfang:12 pages
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ISSN:
-
Medientyp:Aufsatz (Zeitschrift)
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Format:Print
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Sprache:Englisch
- Neue Suche nach: 571.95
- Weitere Informationen zu Dewey Decimal Classification
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Klassifikation:
DDC: 571.95 -
Datenquelle:
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P-21 Recovery of cardiovascular parameters in beagle dogs after excitement induced by human contactAbe, J. / Harada, T. / Shiotani, M. / Hamada, Y. et al. | 2005
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P-32 Structure-phototoxicity relationship in Balb/c mice treated with fluoroquinolone derivatives, followed by ultraviolet-A irradiationYabe, K. / Goto, K. / Yamamoto, Y. / Jindo, T. / Sekiguchi, M. / Furuhama, K. et al. | 2005
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P-33 Depressive effects of immunosuppressant and anti-inflammatory drugs on HgCl~2-induced inflammatory lesions in Brown Norway ratKanabayashi, T. / Suzuki, K. / Imaoka, K. / Uetsuka, K. / Nakayama, H. / Doi, K. et al. | 2005
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P-38 Placental-transfer of tetrabromobisphenol A in miceFujitani, T. / Tada, Y. / Ogata, A. / Takahashi, H. / Yano, N. / Yuzawa, K. / Nagasawa, A. / Ando, H. / Kubo, Y. / Kamimura, H. et al. | 2005
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P-37 Effects of in utero propylthiouracil exposure on the monoamine content of the rat fetus brainOhtake, S. / Ikeda, T. / Araki, S. / Shibata, S. / Isobe, M. / Hisada, S. et al. | 2005
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P-49 Effect of Crassocephalum crepidioides on inducible nitric oxide synthaseTakamatsu, R. / Aniya, Y. / Yoshimi, N. et al. | 2005
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P-53 Comparison of the early gene responses of Ahr-activating chemicals using the Percellome systemNakatsu, N. / Kitajima, S. / Aisaki, K.-i. / Igarashi, K. / Ono, A. / Kodama, Y. / Kanno, J. et al. | 2005
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P-63 Effects of various chemicals on transporter genes in rat liver and primary cultured hepatocytesUeda, H. / Kasahara, T. / Ono, A. / Miyagishima, T. / Urushidani, T. / Nagao, T. et al. | 2005
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P-64 Evaluation of preservation methods for rat liver: (2) Condition of preservation for rat liver tissue dissolved in RLT bufferNitta, H. / Kasahara, T. / Ono, A. / Miyagishima, T. / Urushidani, T. / Nagao, T. et al. | 2005
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P-91 Respiratory effects upon inhalation of bitumen fumes - Results of a subchronic and design of a chronic study in Wistar (WU) ratsCreutzenberg, O. et al. | 2005
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SY1-3 Molecular targets of organotin compounds in endocrine disruption: Do organotin compounds function as aromatase inhibitors in human?Nakanishi, T. / Nishikawa, J.-i. / Tanaka, K. et al. | 2005
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SY1-4 Protective effects of metallothionein against cadmium-induced toxicity and polymorphisms of its geneKita, K. et al. | 2005
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WS1-3 The screening test to evaluate QT prolongationHombo, T. / Tokoro, K. / Kasai, C. et al. | 2005
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WS2-3 Drug research and development in consideration of Gender-specific PharmacotherapyNegishi, E. et al. | 2005
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SS-1 Toxicological bases for micro-dose studyArato, T. / Fueki, O. / Hirose, A. / Kamata, E. / Nomura, M. / Ohno, Y. et al. | 2005
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Y-7 Validation of immortalized human hepatocytes for in vitro screening of hepatotoxicityHorie, H. / Koseki, N. / Oi, S. / Miyawaki, I. / Okamura, H. / Funabashi, H. / Tanaka, K. / Yasuba, M. et al. | 2005
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Y-19 Species difference among mice, hamsters, rats, and guinea pigs in phenobarbital-induced alteration of serum thyroxine levelTakiguchi, R. / Suzuki, H. / Onishi, M. / Yamada, S. / Kato, Y. et al. | 2005
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O-11 Report of current activities of the IUTOX (2004-2007)Inoue, T. et al. | 2005
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O-14 Abnormality of glucose tolerance in obese cynomolgus monkeysKusumoto, S. / Horai, N. / Mochimasu, R. / Kadokura, H. / Haruyama, E. / Funato, M. / Izumi, H. / Tokado, H. / Fukusaki, K. et al. | 2005
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O-18 Protection from liver toxicity induced by lithocholic acid-feeding. -Involvement of cyp3a and hydroxysteroid sulfotransferase-Watase, H. / Hori, W. / Miyata, M. / Nagata, K. / Gonzalez, F. J. / Yamazoe, Y. et al. | 2005
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O-24 Perinatal exposure to low dose diethylstilbestrol (DES) alters uterine response to prepubertal estrogen stimulation and induces multioocyte follicles in prepubescent CD-1 miceMatsushima, Y. / Kanno, J. et al. | 2005
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O-64 Hepatotoxicity of T-2 toxin in miceMiwa, S. / Shinozuka, J. / Murakami, N. / Aruga, C. / Fujimura, H. / Toriumi, W. et al. | 2005
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O-62 Glutathione-S-transferase and dialdehyde reductase activities toward aflatoxin B~1 in livers of experimental and farm animalsTulayakul, P. / Sakuda, S. / Dong, K.-S. / Kumagai, S. et al. | 2005
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O-73 cDNA microarray analysis on mechanism of serum alpha 2u-globulin depression by diethylstilbestrol (DES) administration in male ratTakeyoshi, M. / Miyaura, H. et al. | 2005
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P-17 Analysis by lectin histochemistry of kidney in Gottingen origin miniature pigsFukuoka, A. / Fujii, E. / Karasawa, Y. / Tsutsumi, H. / Ito, T. / Suzuki, M. / Sugimoto, T. et al. | 2005
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P-40 Effects of aflatoxin B~1 in pregnant mice and ratsHossain, M. M. / Nakayama, H. / Ueno, M. / Yamauchi, H. / Uetsuka, K. / Doi, K. et al. | 2005
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P-69 Evaluation of genotoxicity with various crude drugsZheng, M.-S. / Lee, M.-Y. / Kim, S.-H. / Lee, H.-Y. / Park, C.-B. / Lee, J.-S. / Lee, B.-K. / Kang, J.-K. et al. | 2005
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P-72 Dose dependent promoting effects of hexachlorobenzene on hepatocarcinogenesis in a rat medium-term liver bioassayImai, N. / Ichihara, T. / Nabae, K. / Hagiwara, A. / Tamano, S. / Shirai, T. et al. | 2005
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P-73 Gingival carcinogenicity in female Harlan Sprague-Dawley rats following two-year oral treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compoundsYoshizawa, K. / Walker, N. J. / Jokinen, M. P. / Brix, A. E. / Sells, D. M. / Marsh, T. / Wyde, M. E. / Orzech, D. / Haseman, J. K. / Nyska, A. et al. | 2005
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P-80 Development of an assay system for canine albumin and measurements of canine albumin in urineNasu, M. / Tayama, M. / Kamiya, K. / Kawashita, R. / Seki, T. / Yamamoto, K. et al. | 2005
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P-83 Introduction of the in vivo Mini-tox study as an effective tool to improve confidence in safety in the early stage of drug development (2) Effects of atypical antipsychotics XSato, Y. / Fujikawa, M. / Shirai, M. / Iidaka, T. / Yamada, H. / Horii, I. et al. | 2005
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P-82 Conducting a comprehensive toxicological evaluation of nanomaterialsHolsapple, M. / Thomas, K. et al. | 2005
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P-87 Influence of locomotor activity on rat respiratory function using whole body plethysmographyTakatani, H. / Hashimoto, Y. / Yano, K. / Nishida, A. / Kitamura, K. et al. | 2005
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P-92 The Relationships between sex difference of the incidence of diabetes and histopathological changes of the pancreas in new Spontaneously Diabetic Torii (SDT) ratShoda, T. / Shinohara, M. / Takahashi, T. / Masuyama, T. / Miyajima, K. / Koizumi, H. / Sugai, S. / Miyakawa, Y. et al. | 2005
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P-99 Circadian variation in feeding behaviour of rodents receiving powdered diet on regulatory toxicity studies - The ratEverett, D. / Jones, R. / Haleema, F. et al. | 2005
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SL-2 Epigenetics in toxicology research: Application of genome-wide DNA methylation profilesShiota, K. et al. | 2005
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EL-1 Current status and future aspects of toxicological biomarkers in safety evaluationHorii, I. et al. | 2005
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SY1 Molecular mechanism for toxicity of metalsTohyama, C. / Naganuma, A. et al. | 2005
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Y-6 Relationship between hepatocellular apoptosis and Kupffer cell activation in the livers of rats treated with cycloheximideKumagai, K. / Kiyosawa, N. / Kawai, R. / Ishikawa, K. / Hakamata, S. / Ito, K. / Yamoto, T. / Manabe, S. / Teranishi, M. et al. | 2005
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Y-11 Charastalistics of delayed rectiire K^+ current in in vivo model of rabbi heartNishina, T. / Kuwahara, M. / Tsubone, H. et al. | 2005
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Y-13 Comparison of the effects of Ca^2^+ blockers on cardiovascular system in cynomolgus monkeys and beagle dogs using telemetry systemShigeyama, T. / Torikai, Y. / Magotani, H. / Suzuki, A. / Hijioka, M. / Kuwano, K. / Fukuzaki, K. / Nagata, R. / Kito, G. et al. | 2005
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Y-21 Assessment of T cell dependent antibody response, hematology, pathology and immunophenotyping in the identical rat on immunotoxicology studies. -Immunotoxicology study with cyclophosphamide-Kurogi, K. / Naohara, K. / Kouchi, M. / Aoki, Y. / Tanaka, K. / Yasuba, M. et al. | 2005
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Y-28 Mechanistic study on hepatocarcinogenesis induced by dicyclanil in mice: Possible involvement of oxidative stressMoto, M. / Umemura, T. / Okamura, M. / Muguruma, M. / Kashida, Y. / Mitsumori, K. et al. | 2005
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Y-33 Screening for determinant proteins of adriamycin sensitivity in Saccharomyces cerevisiaeTakahashi, T. / Hirose, K. / Naganuma, A. et al. | 2005
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O-8 Recent situation and future perspectives of accrediting toxicologists in JapanTsuda, S. et al. | 2005
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O-10 Toxicologist Certification and IART (International Assembly for the Recognition of Toxicologists)Horii, I. et al. | 2005
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O-28 Enigma of oxidative stress in benzene induced hematotoxicity answered by thioredoxin-overexpression mouseHirabayashi, Y. / Kawasaki, Y. / Yodoi, J. / Li, G.-X. / Yoon, B.-I. / Kaneko, T. / Kurokawa, Y. / Nagao, T. / Kanno, J. / Inoue, T. et al. | 2005
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P-4 90-day repeated dose toxicity study of gum arabicDoi, Y. / Ichihara, T. / Yoshino, H. / Hagiwara, A. / Ogasawara, T. / Sasaki, Y. / Nakamura, M. / Asamoto, M. / Shirai, T. et al. | 2005
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P-19 Chemical-induced atrial thrombosis in rodent NTP studies: Morphological aspects and potential mechanismsYoshizawa, K. / Kissling, G. E. / Johnson, J. A. / Nyska, A. et al. | 2005
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P-29 Tissue distribution of rat plasma released enzymesIsobe, M. / Ikeda, T. / Araki, S.-i. / Shibata, S. / Ootake, S. / Hisada, S. et al. | 2005
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P-57 Gene expression analysis on rat livers treated with L-buthionine (S,R)-sulfoximine - investigation of data compatibility between RG U34A and RAE 230A GeneChips -Kiyosawa, N. / Ito, K. / Watanabe, K. / Niino, N. / Kanbori, M. / Yamoto, T. / Manabe, S. / Matsunuma, N. et al. | 2005
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P-90 Development of in vitro 3T3 cell neutral red uptake phototoxicity screening systemZhou, Y. / Sakimura, M. / Fujikawa, M. / Aoyama, H. / Yamada, H. / Horii, I. et al. | 2005
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P-93 Advanced techniques in regulatory toxicologySpringall, C. / Kelly, J. et al. | 2005
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P-97 Advancing the State-of-the-Science of immunotoxicology: Risk assessment and regulatory guidelinesHolsapple, M. / Faherty, C. et al. | 2005
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SY2-3 Transporter-mediated toxicity in the nephrotoxicity of organic compoundsKanai, Y. / Endou, H. et al. | 2005
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WS1-1 Current status of computational toxicologyNaeshiro, I. et al. | 2005
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Y-1 Screening of proteins that degradated by ubiquitin-proteasome system and involved in enhancement of metylmercury toxicityOgiwara, Y. / Hwang, G.-W. / Naganuma, A. et al. | 2005
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Y-27 Protective effect of metallothionein on benzo[a]pyrene-caused DNA damageTakaishi, M. / Kurita, H. / Suzuki, J. S. / Tohyama, C. / Satoh, M. / Nagase, H. et al. | 2005
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Y-29 N-methyl-N-nitrosourea induced rat prostate carcinogenesis is modulated by prenatal 3,3',4,4',5-pentachlorobiphenyl exposureSanuka, N. / Yokoo, K. / Takahashi, H. / Muto, T. / Suzuki, Y. / Kanai, Y. / Hano, H. / Furusato, M. / Endou, H. / Wakui, S. et al. | 2005
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O-2 The protective effect of Proheparum in a rat model of thioacetamide-induced hepatic fibrosisMa, C. / Maeda, N. / Nakaoka, K. / Sun, Z. / Ishii, M. / Oshikata, T. / Mizumachi, R. / Imaizumi, M. / Atai, H. / Nishi, K. et al. | 2005
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O-39 Effects of insulin-sensitizing agent on autonomic nervous function in Zucker-fatty ratsTowa, S. / Toriumi, W. / Kuwahara, M. / Tsubone, H. et al. | 2005
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O-55 Evaluation of radiation-induced brain developmental effect by neuronal apoptosis in mouse fetusIshida, Y. / Ohmachi, Y. / Hiraoka, T. / Fushiki, S. / Shimada, Y. / Ogiu, T. et al. | 2005
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P-1 Effects of single or 10-day repeated intratracheal administration of bleomycin to ratsGoto, H. / Senba, T. / Shimomura, Y. / Ishiharada, N. / Tahara, T. / Morishita, K. et al. | 2005
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P-14 Liver injury; Differences in hepatic ischemia reperfusion between juvenile and adult ratsFujishima, K. / Nakano, Y. / Shibazaki, Y. / Kurosawa, T. et al. | 2005
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P-18 Determination of cardiovascular and respiratory parameters by an integrated telemetry system (ITS) in monkeysNiehoff, M. / Nowak, P. / Zuhlke, U. / Weinbauer, G. F. / Muller, W. / Vogel, F. et al. | 2005
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P-43 Effects of in utero and lactational exposure to flutamide in SD rats: Comparison of the effects of administration periodsNoda, S. / Muroi, T. / Takakura, S. / Takatsuki, M. / Yamasaki, K. et al. | 2005
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P-55 Gene expression profiling of a gene-targeted mouse embryo using the "Percellome" system as a model for molecular developmental toxicityKitajima, S. / Aisaki, K.-i. / Igarashi, K. / Nakatsu, N. / Saga, Y. / Kanno, J. et al. | 2005
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P-56 Current status of pharmaceutical industries in Japan on pharmacogenomics and toxicogenomics in 2005Kawahara, J.-i. / Inoue, A. / Ohkura, T. / Matsumoto, S. / Kohira, T. / Nomoto, S. / Kotosai, K. / Unno, T. / Naito, S. / Sagami, F. et al. | 2005
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P-66 Development of exposure system of intermediate frequency magnetic fields for in vitro research and evaluation of mutagenisity of the magnetic fields by bacterial mutation testNakasono, S. / Ikehata, M. / Nishimura, I. / Negishi, T. / Shigemitsu, T. et al. | 2005
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P-67 Data characteristic of in vitro micronucleus test in CHL cellsTakase, J. / Enjo, H. / Matsuzaki, H. / Kobayashi, T. / Ota, M. / Yamanaka, Y. / Kasahara, Y. et al. | 2005
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P-68 Comparison of sensitivity between the miniscreen and standard Ames assays using Ames-positive compounds from in-house dataMiyata, N. / Aoki, T. / Shimada, C. / Koguchi, A. / Imahie, H. / Kitamura, K. et al. | 2005
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P-79 Evaluation of measurement and differentiation of nucleated cell in bone marrow using hematology analyzer XT-2000iV for laboratory animalsOda, Y. / Miyamoto, K. / Koeda, N. / Ooe, M. / Hanaka, N. / Toyota, N. / Sakata, T. et al. | 2005
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P-89 Effects of angiogenesis inhibitors on human prostate cancer cell line PC-3Taniguchi, K. / Sun, Z. / Morikawa, T. / Watanabe, N. / Imaizumi, M. / Atai, H. / Nishi, K. et al. | 2005
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P-95 Cryo Tissue Micro Arrays - A novel approach to high throughput therapeutic biopharmaceutical screeningSpringall, C. / Postoyalko, A. et al. | 2005
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P-96 Comparison of hybridization and wash procedures for Agilent 60mer oligonucleotide microarraysXiao, J. / Lucas, A. / Delenstarr, G. / Argonza-Barrett, R. / Bjeldanes, E. / Welebob, L. / Minoura, K. / Wolber, P. et al. | 2005
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SY2 Analysis of toxicological mechanisms: A toxicogenomics approachNagao, T. / Doi, K. / Nakayama, H. et al. | 2005
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Y-20 Time-course changes of hematology and clinical chemistry values in pregnant ratsHonda, T. / Honda, K. / Yamaguchi, C. / Nishimura, T. / Hasegawa, M. / Nishida, A. / Inui, T. / Kitamura, K. et al. | 2005
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Y-23 Effects of D-calnitin on cultred rat embryosYokoyama, A. / Yokoyama, H. et al. | 2005
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Y-25 Strain differences in phenobarbital metabolism between SD and Wistar ratsKishida, T. / Takashima, K. / Muto, S.-i. / Souma, S. / Kasahara, H. / Kobayashi, S. / Motokawa, Y. / Tanaka, S. / Tsutsui, M. / Hayashi, M. et al. | 2005
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Y-26 Relationship between liver weight change and gene expression of hepatic cytochrome P450 isoforms in clobazam-treated ratsMiyawaki, I. / Horie, H. / Kouchi, M. / Mise, I. / Funabashi, H. / Tanaka, K. / Yasuba, M. et al. | 2005
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Y-36 Transport of methylmercury through the epithelial type amino acid transport system B^0Islam, R. / Jutabha, P. / Chairoungdua, A. / Hirata, T. / Anzai, N. / Kanai, Y. / Endou, H. et al. | 2005
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O-6 Expression profiles of cytochrome P450 enzymes in the uterus and liver of female rats treated with indole-3-carbinolYoshida, M. / Nakae, D. / Maekawa, A. et al. | 2005
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O-13 Investigation of the use of oil-based vehicle for reproductive and developmental toxicity studies in rabbits. -In use of olive oil-Tateishi, T. / Nakano, Y. / Imai, N. / Yonemori, Y. / Oneda, S. / Fukunishi, K. et al. | 2005
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O-20 Bile acid sulfates as a possible early marker of liver toxicityHori, W. / Mizuki, T. / Miyata, M. / Nagata, K. / Gonzalez, F. J. / Yamazoe, Y. et al. | 2005
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O-33 Comparison of four types of rate-correcting methods for QT interval: Which methods can better reflect the delayed rectifier K^+ channel-inhibition in the halothane-anesthetized guinea pigs?Takahara, A. / Sugiyama, A. / Sakaguchi, Y. / Nakamura, Y. / Hashimoto, K. et al. | 2005
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O-41 Detection and characterization of mitomycin C-induced gene mutations and micronuclei in the gpt delta L1 cellTakeiri, A. / Mishima, M. / Tanaka, K. / Harada, A. / Shinkura, H. / Masumura, K.-i. / Nohmi, T. et al. | 2005
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O-44 Difference between tamoxifen and toremifene in hepatocarcinogenic activity toward female rats: Study on the gene expression of hepatic proteins responsible for DNA repair and cell proliferationHashiba, M. / Kasahara, T. / Degawa, M. et al. | 2005
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O-50 In vitro two-stage short-term assay for carcinogensTanaka, N. / Umeda, M. / Asada, S. / Ono, H. et al. | 2005
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O-56 Serum-free culture of murine embryonic stem (ES) cells for the analysis of developmental toxicityTakagi, A. / Kanno, J. et al. | 2005
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O-59 Effects of heavy metal exposure on the phosphorylation of p53 proteinMatsuoka, M. et al. | 2005
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O-60 Effect of metallothionein on cadmium accumulation in fetusHonda, A. / Satoh, M. / Hasegawa, T. / Seko, Y. / Suzuki, J. S. / Tohyama, C. / Nagase, H. et al. | 2005
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O-61 Effects of methylmercury on the intercellular trafficking in Saccharomyces cerevisiaeMurai, Y. / Hwang, G.-W. / Naganuma, A. et al. | 2005
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O-65 T-2 toxin induced apoptosis in rat keratinocyte primary culturesAlbarenque, S. M. / Suzuki, K. / Doi, K. et al. | 2005
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O-72 Development of gene and protein expression screening-based toxicogenomics system using human primary normal neuronal cellsKanemura, Y. / Yamazaki, T. / Kobayashi, S. / Yamada, T. / Shofuda, T. / Mori, H. / Yamasaki, M. / Tsunoda, T. / Miya, F. / Okano, H. et al. | 2005
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P-36 A study to investigate the incidence of headless sperm in rat urineShimomura, K. / Shimada, M. / Hagiwara, M. / Kato, M. / Furuhama, K. et al. | 2005
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P-44 Effect of Phenobarbital on hepatic enzyme induction in juvenile ratsAsaoka, Y. / Itamura, R. / Horimoto, M. / Horii, I. et al. | 2005
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P-75 Two-year study of carcinogenicity and chronic toxicity of p-nitroanisole in rats and miceKano, H. / Yamazaki, K. / Matsumoto, M. / Yamamoto, S. / Matsushima, T. et al. | 2005
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SS-3 Aspects from industrial chemicals safety asssessmentHirose, A. / Kamata, E. et al. | 2005
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Y-2 Nitrofurazone-induced changes in the rat liverIto, K. / Kajikawa, S. / Nii, A. / Hanada, T. / Doi, K. et al. | 2005
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Y-24 Recovery from pregnancy-induced down-regulation of cytochrome P450 isozymes (CYPs) protein levels in postpartum rat liverHe, X. J. / Ejiri, N. / Nakayama, H. / Doi, K. et al. | 2005
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Y-31 Molecular mechanisms of prostate enlargement induced with perinatal exposure of MXC in ratsOhtsuka, R. / Takeda, M. / Yamaguchi, S. / Hayashi, K. / Takeuchi, Y. / Kuwahara, M. / Takahashi, N. / Chiba, Y. / Kosaka, T. / Harada, T. et al. | 2005
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Y-34 Evaluation of testicular toxicology in puberty to adult rats with prenatal exposure for 3,3',4,4',5-pentachlorobiphenylAkagi, Y. / Yokoo, K. / Takahashi, H. / Muto, T. / Suzuki, Y. / Kanai, Y. / Hano, H. / Furusato, M. / Endou, H. / Wakui, S. et al. | 2005
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O-12 Investigation of histamine release after single intravenous administration of polysorbate 80 to beagles, cynomolgus monkeys, and ratsHaruyama, E. / Kodama, R. / Sakamoto, K. / Koyama, S. / Nakama, K. / Izumi, T. / Wakamatsu, S. / Kusumoto, S. / Izumi, H. / Tokado, H. et al. | 2005
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O-25 Effect of perinatal exposure to diethylstilbestrol (DES) on mammary differentiation and tumorigenesis in female ratsMiyajima, K. / Takekoshi, S. / Kakimoto, K. / Koizumi, H. / Shoda, T. / Iwasaka, T. / Takahashi, A. / Naito, M. / Masuzaki, Y. / Miyakawa, Y. et al. | 2005
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O-32 Usefulness of monophasic action potential as a measurement parameter of QT prolongation in anesthetized guinea pigs in early drug development stageBeppu, N. / Sasaki, A. / Obo, M. / Katayama, S. / Ando, K. et al. | 2005
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O-58 Granulosa cell is type II apoptosis-cell and regulates follicular atresia in mammalian ovariesManabe, N. / Minehata, F. / Goto, Y. / Inoue, N. / Maeda, A. / Cheng, Y. / Anann, S. / Sai, T. / Li, J. et al. | 2005
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P-11 Toxicity study of Garcinia cambogia extract (3): Testicular toxicity of hydroxycitric acid in miceOgawa, Y. / Sekita, K. / Kitajima, S. / Saitoh, M. / Matsushima, Y. / Yamamoto, M. / Kodama, Y. / Inoue, T. / Kanno, J. et al. | 2005
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P-25 A basic research of regional variation of cholinesterase activity in the rat brainShutou, Y. / Kojima, S. / Sasaki, A. / Fujie, H. / Hayashi, K. / Matsumoto, T. / Hayashi, Y. / Kimura, T. / Tajima, Y. / Fukuyama, T. et al. | 2005
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P-26 Effects of ethynyl estradiol on the expression of Wnt-related genes in the uterus of immature female ratsKatayama, S. / Ashizawa, K. / Fukuhara, T. / Hiroyasu, M. / Nagai, K. / Andou, K. et al. | 2005
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P-30 Measurement of bone marrow cells in dogsKojima, S. / Sasaki, J. / Kuwahara, M. / Nakashima, N. / Harada, T. et al. | 2005
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P-45 Induction of rat hepatic CYP 1A1, 1B1, and AhR by 7,12-dimethylbenz[a]anthracene on prenatal 3,3',4,4',5-pentachlorobiphenyl exposureWakui, S. / Yokoo, K. / Takahashi, H. / Muto, T. / Suzuki, Y. / Kanai, Y. / Hano, H. / Furusato, M. / Endou, H. et al. | 2005
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P-74 Two-year study of carcinogenicity and chronic toxicity of cyclohexene in rats and miceKasai, T. / Ohsawa, M. / Saito, A. / Nisizawa, T. / Yamamoto, S. / Matsushima, T. et al. | 2005
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P-77 Evaluation of physical dependence of diazepam by oral gavage administration in ratsNakagawa, Y. / Katsumata, S. / Ohtsui, T. / Shiozaki, Y. / Komeno, M. / Katsube, N. et al. | 2005
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P-78 The characteristics of ovariectomized rats as an obese modelYamashita, K. / Ishii, H. / Otake, S. / Toyota, N. / Iida, M. et al. | 2005
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P-81 Hormonal changes in estrous cycle and circadian rhythm in beagle dogsNakashima, Y. / Hangai, J. / Seki, T. / Takagi, T. / Uchida, H. / Nasu, M. et al. | 2005
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P-84 Method for RNA extraction from formalin-fixed, paraffin-embedded tissuesSakimura, M. / Hamada, Y. / Horii, I. et al. | 2005
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P-85 Relationship between estrus cycles and plasma hormone in ratsIwamoto, A. / Ohta, T. / Nakashima, Y. / Nasu, M. / Kawashima, K. et al. | 2005
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P-86 Efficiency of toxicological screening at drug-discovery stage (2) Establishment of high-throughput screening system for detection of phospholipidosisKasahara, T. / Tomita, K. / Ozawa, M. / Murano, H. / Harada, T. / Ogihara, T. / Kakinuma, C. / Ohnishi, S. et al. | 2005
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WS2-2-1 Preclinical safety studies of anticancer agents. -Cytotoxic agents-Onodera, H. et al. | 2005
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O-15 Comparison of the sensitivity of various in vivo animal models for detecting the drug-induced QT interval prolongationAkie, Y. / Sakaguchi, Y. / Tate, Y. / Ishiyama, Y. / Sugiyama, M. / Fujino, A. / Sugiyama, A. et al. | 2005
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O-22 Induction of Cytochrome P450 isozymes by phenobarbital in pregnant rat and fetal livers and placentaEjiri, N. / Kiyosawa, N. / Katayama, K.-i. / Uetsuka, K. / Nakayama, H. / Doi, K. et al. | 2005
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O-23 Effects of restricted feeding on daily rhythm of hepatic P450 monooxygenase activities in male ratsHirao, J. / Arakawa, S. / Watanabe, K. / Ito, K. / Furukawa, T. et al. | 2005
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O-27 Uterotropic assay in immature and ovariectomized female rats - A comparison between oral and subcutaneous administrationFukuyama, T. / Hayashi, K. / Tajima, Y. / Fujie, H. / Matsumoto, T. / Hayashi, Y. / Kuwahara, M. / Enomoto, A. / Ueda, H. / Shutou, Y. et al. | 2005
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O-47 MMP/TIMP activities in DMBA-induced rat mammary gland tumorsKawai, K. / Uetsuka, K. / Nakayama, H. / Doi, K. et al. | 2005
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O-48 Follow-up studies on assessment of QT interval prolongation. -Carlson's model in rabbits-Ikeda, H. / Nagao, T. / Tsutsumi, H. / Kimura, A. / Kimura, I. / Nishimori, T. et al. | 2005
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O-57 Changes of sperm functions and epididymal gene expression in the rats treated with sulfasalazine for several daysFukushima, T. / Komiyama, M. / Mori, C. / Hamada, Y. / Horii, I. et al. | 2005
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P-16 Cisplatin-induced rat renal interstitial fibrosis, with special references to participation of different macrophage populations and epithelial-myofibroblastic transitionYamate, J. / Kuwamura, M. / Kotani, T. et al. | 2005
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P-22 Effects of cholesterol diet on vasculopathy and nephropathy in salt-loaded Dahl-S ratsIchikawa, A. / Jiang, J. / Kawai, S. / Kanda, M. / Kunishiro, K. / Shirahase, H. / Uehara, Y. et al. | 2005
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P-20 Availability of miniature pigs for the evaluation of cardiovascular system affected by drugsShin, M. / Ito, M. / Tabo, M. / Asanuma, K. / Tsutsumi, H. / Katagiri, K. / Kawarada, S. / Tsubone, H. / Kuwahara, M. / Kimura, K. et al. | 2005
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P-27 Application of jugular vein technique for blood sampling on studies of adrenal-related hormones in ratsIto, K. / Kawasaki, K. / Tsukamono, T. / Hamashima, T. et al. | 2005
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P-41 Effects on embryo-fetal development in rats treated with MMS at the preimplantation stagesYokoi, R. / Suda, S. / Terashima, Y. / Yasue, K. / Nagate, T. / Kobayashi, K. / Kuroda, J. / Shibata, N. et al. | 2005
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P-46 Kinetics of quinidine in plasmaHojo, T. / Saitoh, T. et al. | 2005
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P-60 Evaluation of preservation methods for rat liver: (3) Influence of time to preservation of liver tissue on RNA qualityKasahara, T. / Miyazaki, T. / Ono, A. / Miyagishima, T. / Urushidani, T. / Nagao, T. et al. | 2005
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P-102 Intravenous administration of rhASA in juvenile ratsOshodi, T. / Ratcliffe, K. / Eistrup, C. et al. | 2005
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SY2-4 Toxicogenomic approach to the prediction of carcinogenic potentials of heterocyclic amines in rat colonNakagama, H. / Nakanishi, M. / Fujiwara, K. / Nagao, M. / Sugimura, T. / Ochiai, M. et al. | 2005
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Y-4 Genomic biomarker for cholestasisYamamoto, T. / Utsumi, H. / Matsuoka, N. / Tsutsui, N. et al. | 2005
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Y-12 Effect of beta3 adrenoceptor agonist on hemodynamics in anesthetized cynomolgus monkeysMagotani, H. / Torikai, Y. / Shigeyama, T. / Suzuki, A. / Hijioka, M. / Kuwano, K. / Fukuzaki, K. / Nagata, R. / Kito, G. et al. | 2005
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Y-15 Development of neurological examination in beagle dogsOnishi, Y. / Hirota, R. / Kajikawa, S. / Takeda, N. / Kasuga, T. et al. | 2005
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Y-30 A toxicogenomic approach to drug-induced phospholipidosis: Analysis of its induction mechanism and establishment of a novel in vitro screening systemSawada, H. / Taniguchi, K. / Takami, K. / Asahi, S. et al. | 2005
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O-29 Point mutation in PU.1 in radiation-induced mouse myeloidleukemiaOhmachi, Y. / Kuwahara, Y. / Tsuji, S. / Tsuji, H. / Ban, N. / Kakinuma, S. / Nishimura, M. / Ishida, Y. / Aizawa, S. / Shimada, Y. et al. | 2005
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O-35 Evaluation of drug-induced QT prolongation in conscious marmosetsHara, T. / Sone, S. / Shishido, N. / Kuramoto, S. / Nakano, K. / Onodera, H. / Tabo, M. / Kimura, K. / Kobayashi, K. et al. | 2005
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O-40 In vivo mutagenicity and oxidative DNA damage in the livers of gpt delta mice treated with flumequineKuroiwa, Y. / Umemura, T. / Masumura, K.-i. / Kanki, K. / Ishii, Y. / Kodama, Y. / Nohmi, T. / Nishikawa, A. / Hirose, M. et al. | 2005
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O-66 Juvenile safety assessment and toxicity testing; Capability at central toxicology laboratoryLewis, R. W. et al. | 2005
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O-67 Effects of hepatic drug-metabolizing enzyme induction on blood coagulation in rats (2)Okamura, T. / Mochizuki, M. / Shimizu, S. / Itayagoshi, S. / Ohishi, T. / Hatayama, K. / Yamamoto, S. / Warita, K. / Edamoto, H. / Okazaki, S. et al. | 2005
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O-71 Development of novel safety test for vaccines using DNA microarray technologyNaito, S. / Imai, J. / Kato, H. / Kawamura, M. / Hamaguchi, H. / Mizukami, T. / Maeyama, J. / Ochiai, M. / Yamamoto, A. / Horiuchi, Y. et al. | 2005
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P-24 beta-amyloid and tau pathology in the cynomolgus monkeyBuse, E. / Niggemann, K. / Friderichs-Gromoll, S. / Habermann, G. / Kaspareit, J. / Nowak, P. / Weinbauer, G. F. et al. | 2005
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P-42 Reproductive toxicity testing and control background data in the cynomolgus monkeyOneda, S. / Makori, N. / Congdon, W. C. / Mori, Y. / Okasaki, K. / Steven, M. et al. | 2005
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P-61 Evaluation of preservation methods for rat liver: (1) Evaluation of tissue preservation by using RNAlaterMiyazaki, T. / Kasahara, T. / Ono, A. / Miyagishima, T. / Urushidani, T. / Nagao, T. et al. | 2005
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P-62 Gene expression profiling in rat and human primary cultured hepatocytes treated with ethionineMatsushita, T. / Ono, A. / Urushidani, T. / Miyagishima, T. / Nagao, T. et al. | 2005
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P-76 Comparison of sensitivity between pulsed and continuous administration on uterotrophic assayUsuda, K. / Abe, M. / Ogawa, I. / Furukawa, S. et al. | 2005
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SY2-2 DNA damage-induced toxicity and repair system in the developing fetal brainUeno, M. / Katayama, K.-i. / Yamauchi, H. / Nakayama, H. / Doi, K. et al. | 2005
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WS2-2-2 Preclinical safety studies of anticancer agents. -Non-cytotoxic agents-Kai, S. et al. | 2005
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Y-16 Histopathological changes in the brain of mouse fetuses by etoposide-administrationNam, C. / Woo, G. H. / Uetsuka, K. / Nakayama, H. / Doi, K. et al. | 2005
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O-3 ^1H-NMR based metabonomics study of galactosamine, methylene dianiline, and clofibrate in ratsKatsutani, N. / Aoki, T. et al. | 2005
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O-17 Gene expression profiling of rat kidneys following dose of edaravone in combination with cefalotin and glycerolShimizu, T. / Masutomi, N. / Ishii, S.-i. / Ohyama, N. / Okada, M. / Sugimoto, J. / Nakayama, K. / Sekijima, M. / Mutai, M. et al. | 2005
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O-19 Expression of hydroxysteroid sulfotransferase involved in protection against bile acid-induced hepatotoxicityMiyata, M. / Matsuda, Y. / Tsuchiya, H. / Nagata, K. / Gonzalez, F. J. / Yamazoe, Y. et al. | 2005
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O-45 Difference of molecular alteration between radiation-induced and N-ethyl-N-nitrosourea-induced thymic lymphomas in B6C3F1 miceKakinuma, S. / Nishimura, M. / Amasaki, Y. / Imaoka, T. / Ohmachi, Y. / Shimada, Y. et al. | 2005
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O-46 Expression of a system L amino acid transporter at testis of rats after prenatal exposure to di(n-butyl)phateMuto, T. / Kanai, Y. / Wakui, S. / Endou, H. et al. | 2005
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P-6 Changes of 1,25(OH)~2D~3-induced calcium action in the total parenteral nutrition feeding rat (examination of dose-dependent action)Asanuma, K. / Komatsu, S.-i. / Sakurai, T. / Takai, R. / Chiba, S. et al. | 2005
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P-28 Glycyrrhizin induced hypokaliemia in laboratory animalKido, A. / Kubota, K. / Tsuchiya, N. / Kanitani, M. / Yanagisawa, T. / Kase, Y. / Takeda, S. / Aburada, M. et al. | 2005
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P-54 Analysis of the effect of dietary phytoestrogens on the gene expression profiles of endocrine disruptors using the "Percellome" systemIgarashi, K. / Nakatsu, N. / Matsushima, Y. / Aisaki, K.-i. / Kitajima, S. / Kanno, J. et al. | 2005
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P-70 Use of IC tags in short-term carcinogenicity studies on CB6F1-TgrasH2 miceUrano, K. / Machida, K. / Nishinaka, E. / Eguchi, N. / Yoshimura, M. / Sawa, N. / Kikuchi, K. / Tanabe, A. / Hattori, Y. / Suzuki, S. et al. | 2005
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P-98 Determination of zearalenone and aflatoxins in maizePoapolathep, A. / Poapolathep, S. / Noonpugdee, C. / Klangkaew, N. / Kumagai, S. / Doi, K. et al. | 2005
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SL-1 Association between the genetic polymorphism of CYP2A6 and tobacco-related cancer riskKamataki, T. et al. | 2005
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EL-2 Metabolic nuclear receptor and chemical-induced liver toxicityYamazoe, Y. / Miyata, M. / Matsubara, T. / Nagata, K. et al. | 2005
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SY2-1 Toxicological analysis of hepatotoxicants in the toxicogenomics project databaseUrushidani, T. et al. | 2005
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WS1-4 Toxicogenomics, Proteomics and MetabonomicsYamoto, T. / Maeda, N. / Manabe, S. et al. | 2005
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Y-8 Participation of NADPH oxidase and ERK activation in zinc-induced renal cell injury in LLC-PK1 cellsKohda, Y. / Matsunaga, Y. / Kawai, Y. / Gemba, M. et al. | 2005
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Y-32 Urinary metabonomics analysis in amiodarone-induced phospholipidosis of rat by FT-ICR-MSHasegawa, M. / Hasegawa, Y. / Takenaka, S. / Kuwamura, M. / Tsuyama, S. et al. | 2005
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O-16 Effect of dosing interval between edaravone and cefalotin/glycerol on the nephrotoxicity in ratsOhyama, N. / Ishii, S.-i. / Shibata, H. / Okada, M. / Inoue, Y. / Sugimoto, J. / Shintaku, Y. / Sugiyama, A. / Mutai, M. et al. | 2005
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O-21 The role of CYP1 family in metabolic activation of benzo[a]pyreneUno, S. / Makishima, M. / Dalton, T. P. / Daniel, W. et al. | 2005
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O-43 In vitro genotoxic potential and liver initiation activity of ciprofloxacinItoh, T. / Sasaki, Y. F. / Kumatani, K. / Sakai, H. / Kashida, Y. / Mitsumori, K. et al. | 2005
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O-53 DNA damage in mouse fetal liver and genital ridge cells induced by in utero exposure of DMN and MMSTsukuba, C. / Matsubara, K. / Takahashi, J. / Sato, I. / Tsuda, S. et al. | 2005
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P-2 Effects of lipophilicity and viscosity of solvents on DPM/LN Background Level in murine local lymph node assayUllmann, L. et al. | 2005
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P-10 Anxiogenic effects of nicotine and cannabinoid receptorsHayase, T. / Yamamoto, Y. / Yamamoto, K. et al. | 2005
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P-23 Analyses of spontaneous arrhythmia in cynomolgus monkeys and beagle dogsSakamoto, K. / Kuribayashi, T. / Kato, T. / Nomura, M. et al. | 2005
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P-39 Experimental study of cleft palate in rats treated with compound that has sterol antisynthesis actionOhta, T. / Ikemi, N. / Yoshida, R. / Kawashima, K. et al. | 2005
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P-50 Efficiency of toxicological screening at the drug-discovery stage (1) Comparison of various cell lines and methods on cytotoxicityMiyauchi, M. / Kasahara, T. / Ozawa, M. / Murano, H. / Ogihara, T. / Ohnishi, S. et al. | 2005
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P-52 The development of Chemical Toxicogenomics Database by the "Percellome" system for the mechanism-based toxicologyKanno, J. / Aisaki, K.-i. / Igarashi, K. / Nakatsu, N. / Kitajima, S. / Ono, A. / Kodama, Y. et al. | 2005
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P-71 The expression of Ras-related molecules in DMBA-induced forestomach tumors in rasH2 miceOkamura, M. / Unami, A. / Matsumoto, M. / Oishi, Y. / Kashida, Y. / Mitsumori, K. et al. | 2005
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P-100 Radio-telemetry monitoring of blood pressure, heart rate, ECG, body temperature and motor activity in rats with indwelling femoral vein cathetersOshodi, T. / Gracie, K. et al. | 2005